DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and Adcy6

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_006520366.3	Gene:	Adcy6 / 11512	MGIID:	87917	Length:	1254	Species:	Mus musculus

Alignment Length:	1320	Identity:	414/1320 - (31%)
Similarity:	595/1320 - (45%)	Gaps:	375/1320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKS----------LFRSGLLT-------------SLLAC--VVSIIIGIVYGQ 106
            |..||.||..::.:|          |..:.|||             :||.|  |:.:::.:|..:
Mouse   222 LERLYQRYFFQMNQSSLTLLMAVLVLLMAVLLTFHAAPAQPQPAYVALLTCASVLFVVLMVVCNR 286

  Fly   107 H-LVQTMLLVLAALISGSILTALQFPAVLS----SPAAALAFAIVTTFSLGTIAAITGDELAPLP 166
            | ..|..:.|::.::.| ||.|:|....|:    ||:|.|.                      .|
Mouse   287 HSFRQDSMWVVSYVVLG-ILAAVQVGGALAANPHSPSAGLW----------------------CP 328

  Fly   167 MYALFLCIHSMLPISWPVSVVLALFMTAIHIV--YRIGTSPDYAPNLPMLFGEIVMLASASVSGL 229
            ::.::: .:::|||....:|:..|.::.:|::  :::.:|..:.  ...|...:|:....:..|:
Mouse   329 VFFVYI-TYTLLPIRMRAAVLSGLGLSTLHLILAWQLNSSDPFL--WKQLGANVVLFLCTNAIGV 390

  Fly   230 YYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRA 294
            .....::.:..:....||..|:.|:.|:.|..|||:|||||:|.::|.|:|..|..|..|
Mouse   391 CTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKED----- 450

  Fly   295 GGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCL 359
                    ..||::::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||
Mouse   451 --------MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 507

  Fly   360 RIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLG 424
            ||||||||||||||||.:|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||
Mouse   508 RIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLG 572

  Fly   425 LRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYL 489
            ||||||||||:|||||||||:||.|||:|||:.||.:|...:|||.|.||.|:|||.:..:|::|
Mouse   573 LRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFL 637

  Fly   490 IVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEK 554
            |:                       ..:::.||.|                        |:: .|
Mouse   638 IL-----------------------GASQKRKEEK------------------------AML-AK 654

  Fly   555 MSPTSINSQEA--PLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGG 617
            :..|..||.|.  |...|
Mouse   655 LQRTRANSMEGLMPRWVP----------------------------------------------- 672

  Fly   618 HRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASN 682
                 |.|.|.:....|...:..||        |...|.||| .:.||..
Mouse   673 -----DRAFSRTKDSKAFRQMGIDD--------SSKDNRGAQ-DALNPED--------------- 708

  Fly   683 SLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTK 747
                 |..|                       |: ||.:...|.:..|.  .||.|
Mouse   709 -----EVDE-----------------------FL-GRAIDARSIDQLRK--DHVRR--------- 733

  Fly   748 YVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTP 812
                                                                    |.:.::...
Mouse   734 --------------------------------------------------------FLLTFQRED 742

  Fly   813 REAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLAL-FLYLSNMSVP 876
            .|..|..:.|..|...:.||.::|..:..:||:|...:..:||...|.|:.|.: .|..:..|..
Mouse   743 LEKKYSRKVDPRFGAYVACALLVFCFICFIQLLVFPYSTLILGIYAAIFLLLLVTVLICAVCSCG 807

  Fly   877 DVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESN 941
            .......:|.....|.:......:.:|.|:.:.||:.|.....|:|        |.       ..
Mouse   808 SFFPKALQRLSRNIVRSRVHSTAVGIFSVLLVFISAIANMFTCNHT--------PI-------RT 857

  Fly   942 FSSVFVNSTLEDV---QLWEIDYAIPI-APV-------------FLYCCAISLAAISAFLRSGFI 989
            .::..:|.|..||   .|.:::|::.: ||:             |:....:||.|.|.||....|
Mouse   858 CAARMLNLTPADVTACHLQQLNYSLGLDAPLCEGTAPTCSFPEYFVGNVLLSLLASSVFLHISSI 922

  Fly   990 LKLIAMLVAVIAQVTVLGYSDL-----------FEMYNDANITHGLPLEIKGF------------ 1031
            .||        |...:||::.|           |:.|:.....|||....:.|
Mouse   923 GKL--------AMTFILGFTYLVLLLLGPPAAIFDNYDLLLGVHGLASSNETFDGLDCPAVGRVA 979

  Fly  1032 ------LLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVAT 1090
                  ::|||..|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.
Mouse   980 LKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAA 1044

  Fly  1091 HFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPK 1154
            |||..| |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:
Mouse  1045 HFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEER 1109

  Fly  1155 FSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRES 1219
            |..:||||||.||||.||||.....| ...||          ::..|.::|:.||..:..||..|
Mouse  1110 FRQLEKIKTIGSTYMAASGLNASTYD-QVGRS----------HITALADYAMRLMEQMKHINEHS 1163

  Fly  1220 FQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYE 1284
            |..|:::||||.|||:||||||:|||||||.|||||:|||||.||..|:|.|.:..::|...||:
Mouse  1164 FNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQ 1228

  Fly  1285 CECRGLTYVKGKGNLVTYFV 1304
            .||||:..|||||.:.|||:
Mouse  1229 LECRGVVKVKGKGEMTTYFL 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	59/253 (23%)
		CYCc	259..467	CDD:214485	125/207 (60%)
		Guanylate_cyc	311..469	CDD:278633	108/157 (69%)
		BASP1	510..667	CDD:283191	24/158 (15%)
		CYCc	1079..1283	CDD:214485	109/204 (53%)
		Guanylate_cyc	1101..1305	CDD:278633	109/204 (53%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	60/270 (22%)
		Guanylate_cyc	456..640	CDD:306677	120/206 (58%)
		DUF1053	668..754	CDD:368844	29/257 (11%)
		Guanylate_cyc	1056..1250	CDD:306677	109/204 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810