Protein Alignment Ac76E and ADCY9

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1466
• Identity: 392/1466 - (26%)
• Similarity: 613/1466 - (41%)
• Gaps: 384/1466 - (26%)

  Fly     3 NHNAETA--KTGNGTNATANLIVKADGNATQPK----AMTSSAARMNDA--------------LS 47
            :|:.|.:  .:|:..:....:..|...:.:.||    :::||.:...|:              ..
Human    12 HHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQ 76

  Fly    48 ASLADLSEQE---------NGTTAEDIHLNDLYTRYRQRLRKSLFRSG---LLTSL--------- 91
            ..|..|.|:.         :....|:..|...:.:.::|.|.:||..|   ||.|:
Human    77 KKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSR 141

  Fly    92 -------LACVVSIIIGI-------VYGQHLVQTML--------LVLAAL------ISG----SI 124
                   ..|.:.:.:|.       :|.:|...|.|        |.|||.      :||    |.
Human   142 LIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSN 206

  Fly   125 LTALQFPA-VLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVVL 188
            |||...|. ...|...:.:..|...|.|.|:        ..||:| |.||    |.:::.|
Human   207 LTATARPTDTCLSQVGSFSMCIEVLFLLYTV--------MHLPLY-LSLC----LGVAYSV---- 254

  Fly   189 ALFMTAIHIVYRIGTSPDY-APNLPMLFGEI----VMLASASVSGLYYRIMSDAAHNRTVDGTRT 248
             ||.|   ..|.......: :|....|..|:    ::.......|::..:||......|......
Human   255 -LFET---FGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQ 315

  Fly   249 GIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMAD-ACQRAGGQASTSATR-------- 304
            .|.....||.|:..:|:::.||:|..||.:     ::|..| ..:.:..:.:||:.:
Human   316 SIMHGKDLEVEKALKERMIHSVMPRIIADD-----LMKQGDEESENSVKRHATSSPKNRKKKSSI 375

  Fly   305 ------FHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKI 363
                  |....:|:...|:|||||||.||.:|::.:|..||..|||||||||::.:|.:|.:|..
Human   376 QKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKIST 440

  Fly   364 LGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKW 428
            ||||||||:|.|..|..||..|:.|||.||.||....:.....|:||:|:|||.||||:||:|::
Human   441 LGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRF 505

  Fly   429 QFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPP 493
            :|||||:||.|||.||..||||:|||::.|..:|.|::|:|.|
Human   506 KFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG---------------------- 548

  Fly   494 KPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPT 558
                     :|:|.:.|                      :.|||.|             :.:...
Human   549 ---------KVIERLGQ----------------------SVVADQL-------------KGLKTY 569

  Fly   559 SINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGD 623
            .|:.|.|.......:.|.:|..|:.                     ||.     :.:.|.||.|
Human   570 LISGQRAKESRCSCAEALLSGFEVI---------------------DGS-----QVSSGPRGQG- 607

  Fly   624 SAASESVAKSAALSLPADDL------------LSMSGSESGISNSGAQAQSSNPASVT------- 669
            :|:|.:|:..|......|:|            .|.:|:|.|...:|.|.:..|...||
Human   608 TASSGNVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFL 672

  Fly   670 --PTAAAP---AGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESF 729
              |..|.|   :||....:.....:|.:..:..:.|  .|..:..:..|.:         :|.|.
Human   673 SVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQ--TSLCEILQEKGRW---------AGVSL 726

  Fly   730 RSHAGHVTRNRPSSKMTKYVECWGADRPFAN-IAESKLVKNIGLASIAMIESNLLPPERKCFNFN 793
            ...|....|.:...:.|        |..|.: |.|..|:|:.           ...|....|:.|
Human   727 DQSALLPLRFKNIREKT--------DAHFVDVIKEDSLMKDY-----------FFKPPINQFSLN 772

  Fly   794 FFGPPTELKPFTMWYRNTPREAMYRAQPDTHFR-------FDLICAFVLFLSLAVVQLIVIE--- 848
            |.....|..     ||.:.:|.:.:..|...|.       .|:..:..:||:|:....:..|
Human   773 FLDQELERS-----YRTSYQEEVIKNSPVKTFASPTFSSLLDVFLSTTVFLTLSTTCFLKYEAAT 832

  Fly   849 ----------LNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLR---- 899
                      .:.|||..:|:..||:.:..:|.     ||.|.|            .|.|.
Human   833 VPPPPAALAVFSAALLLEVLSLAVSIRMVFFLE-----DVMACT------------KRLLEWIAG 880

  Fly   900 -LAMFVVVNILIS--SCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDY 961
             |....:..||:|  :.||:|        .|:.|..:|     .:| .||..|
Human   881 WLPRHCIGAILVSLPALAVYS--------HVTSEYETN-----IHF-PVFTGS------------ 919

  Fly   962 AIPIAPVFLYCCAISLAAISAFLRSGFIL-----KLIAMLVAVIAQVTVLGYSDLFEMYN----- 1016
            |..||.|. ||   :...:|:::||....     .|:.:.|::....:|| .|.|..:.|
Human   920 AALIAVVH-YC---NFCQLSSWMRSSLATVVGAGPLLLLYVSLCPDSSVL-TSPLDAVQNFSSER 979

  Fly  1017 ---DANITHGL--PLEIKG---FLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMR 1073
               ::::...|  |..:.|   .|:..:::|::..|:|:.|...|..:....:..:.:.::::||
Human   980 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMR 1044

  Fly  1074 GINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRL 1138
            .....||.||:|.|||...    :.::.|.:::....|:||||.|:.|||:|.  .:.|.||.|:
Human  1045 DQADWLLRNIIPYHVAEQL----KVSQTYSKNHDSGGVIFASIVNFSEFYEEN--YEGGKECYRV 1103

  Fly  1139 LNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGK-EDGATSRSFADEKRTEEHNVVILV 1202
            |||:|.|||:||.||.:|.|||||||.:|||.||||...: :||:         ..:|| :.||.
Human  1104 LNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGS---------HPQEH-LQILF 1158

  Fly  1203 EFAIALMSILDSINRES-FQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMG 1266
            |||..:|.::|..|... :..|:||:|.||||:.|||||..|..||||.:|||:|||||:.||..
Human  1159 EFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVEC 1223

  Fly  1267 RLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTY 1302
            |:|.:|.:.::|...||:.:.||...|||||.:.||
Human  1224 RIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	61/271 (23%)
		CYCc	259..467	CDD:214485	96/222 (43%)
		Guanylate_cyc	311..469	CDD:278633	85/157 (54%)
		BASP1	510..667	CDD:283191	30/168 (18%)
		CYCc	1079..1283	CDD:214485	93/205 (45%)
		Guanylate_cyc	1101..1305	CDD:278633	96/204 (47%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	44/203 (22%)
		CYCc	326..544	CDD:214485	96/222 (43%)
		Guanylate_cyc	385..573	CDD:278633	95/253 (38%)
		CYCc	1043..1243	CDD:214485	97/215 (45%)
		Guanylate_cyc	1069..1260	CDD:278633	96/203 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810