DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac76E and ADCY8

DIOPT Version :9

Sequence 1:NP_001246838.1 Gene:Ac76E / 40180 FlyBaseID:FBgn0004852 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:1298 Identity:399/1298 - (30%)
Similarity:596/1298 - (45%) Gaps:353/1298 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 LNDLYTRY--RQRLRKSLFRSGL--LTSLLACVV-------------SIIIGIVYGQHLVQTMLL 114
            |..||.||  .||.:..:..:.|  ||.|...|:             .|::|...|..:|...|:
Human   166 LERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALV 230

  Fly   115 VLAALISGSILTALQFPAVLSSPAAALAFAIVTT--FSLGTIAAITGDELAPLPMYALF--LCIH 175
            |:....:..  |.||:..|::       :..:||  .:.|....:.||.:.    |.||  ...:
Human   231 VVRKDTTSH--TYLQYSGVVT-------WVAMTTQILAAGLGYGLLGDGIG----YVLFTLFATY 282

  Fly   176 SMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPML-----FGEIVMLASASVSGLYYRIMS 235
            ||||:....:::..|..:.:.::.::     ..|.|.::     ..:.|:....:.:|::...:|
Human   283 SMLPLPLTWAILAGLGTSLLQVILQV-----VIPRLAVISINQVVAQAVLFMCMNTAGIFISYLS 342

  Fly   236 DAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQAST 300
            |.|..:....||..:|.|::||.|.::||:|:|||:|.::..|:...:.....:..|.       
Human   343 DRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQH------- 400

  Fly   301 SATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILG 365
               :||.:::.|:.||:|||||:..||.||::|:|.:||:.||:||.|||::|.|:.||||||||
Human   401 ---QFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILG 462

  Fly   366 DCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQF 430
            ||||||||||..|..||..||.|||.||..||:||..|..:||||||||:|:|||||||||||||
Human   463 DCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQF 527

  Fly   431 DVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKP 495
            ||||.||.:||.:||||:.||:||:|.|||.|...:.||:|.|..|:.:|..|.:|:|||..|: 
Human   528 DVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPE- 591

  Fly   496 AYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSI 560
                                                     |.||.:    |..||.|.:|    
Human   592 -----------------------------------------DSLLSL----PEDIVKESVS---- 607

  Fly   561 NSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSA 625
                                    ..|..:.....||                      ||... 
Human   608 ------------------------SSDRRNSGATFTE----------------------GSWSP- 625

  Fly   626 ASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAP 690
                       .||.|:::       |..|:.| |.:.|..::.|...|.|       |.|...|
Human   626 -----------ELPFDNIV-------GKQNTLA-ALTRNSINLLPNHLAQA-------LHVQSGP 664

  Fly   691 ERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGAD 755
            |...:::.                    ..:.:.||:..|..                       
Human   665 EEINKRIE--------------------HTIDLRSGDKLRRE----------------------- 686

  Fly   756 RPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQ 820
                                                        .:|||::.::::..|..|...
Human   687 --------------------------------------------HIKPFSLMFKDSSLEHKYSQM 707

  Fly   821 PDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTER 885
            .|..|:.:|:|||::.|.:..:|            |||.|...:.:.:..|.:.:  :|::..  
Human   708 RDEVFKSNLVCAFIVLLFITAIQ------------SLLPSSRVMPMTIQFSILIM--LHSALV-- 756

  Fly   886 NGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESN---FSSVFV 947
                .:..:..|..|.:     ||..:|...                 |:|.|..|   |:|:.:
Human   757 ----LITTAEDYKCLPL-----ILRKTCCWI-----------------NETYLARNVIIFASILI 795

  Fly   948 N--STLEDVQLW-EIDYAIPI-------APVFLYCCA----------ISLAAISAFLRSGFILKL 992
            |  ..:.:: || :.|.:||:       :.||...|:          :::...:.|||...:|||
Human   796 NFLGAILNI-LWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKL 859

  Fly   993 IAML--VAVIAQVTVLGYSDLFEMYNDANITHG----LPLEIKGFLLLLVIILVLHTLDRQGEYV 1051
            ..:|  :|:.|.:|...|:.||..|:  |:.|.    |..:....||:.:.:|.:....:|.||.
Human   860 AVLLIMIAIYALLTETVYAGLFLRYD--NLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYT 922

  Fly  1052 ARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLER-STELYHESYSCVAVMFAS 1115
            ||.||||:.:.|.|..|::.:|..|:.:|.||||:|||.|||..:| :.|||.:||..|.|||||
Human   923 ARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFAS 987

  Fly  1116 IPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKED 1180
            ||.:.:||.:|::|.||:||||||||||.|||:||.:.:|..|||||||.||||..|||.|.|:.
Human   988 IPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQ 1052

  Fly  1181 GATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQ 1245
                   .::|   ..::..|.:|::||...:..||:.||..|.||||::||.|:||||||:|||
Human  1053 -------CEDK---WGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQ 1107

  Fly  1246 YDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKG----KGNLVTYFV 1304
            ||||..|||:||||||.||.||:|..|.|..||...|:..:.||..||||    :|.:.|||:
Human  1108 YDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac76ENP_001246838.1 AC_N <67..289 CDD:292831 57/247 (23%)
CYCc 259..467 CDD:214485 113/207 (55%)
Guanylate_cyc 311..469 CDD:278633 101/157 (64%)
BASP1 510..667 CDD:283191 21/156 (13%)
CYCc 1079..1283 CDD:214485 111/204 (54%)
Guanylate_cyc 1101..1305 CDD:278633 109/208 (52%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182 7/15 (47%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831 57/251 (23%)
CYCc 366..564 CDD:214485 113/207 (55%)
Guanylate_cyc 405..589 CDD:278633 112/183 (61%)
DUF1053 617..711 CDD:283888 28/229 (12%)
CYCc 944..1148 CDD:214485 114/213 (54%)
Guanylate_cyc 973..1172 CDD:278633 109/208 (52%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 32/62 (52%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

Return to query results.
Submit another query.