DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_570093.2	Gene:	Gucy2e / 113911	RGDID:	69322	Length:	1123	Species:	Rattus norvegicus

Alignment Length:	400	Identity:	94/400 - (23%)
Similarity:	179/400 - (44%)	Gaps:	87/400 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 FSLGTIA-------------AITGDEL-----APLPMYALFLCIHSMLPISWPVSVVLALFMTAI 195
            ||||.|.             .::.:|:     :|.|     ||...:.|...|:..:     ..:
  Rat   743 FSLGIILQEVLTRDPPYCSWGLSAEEIIRKVASPPP-----LCRPLVSPDQGPLECI-----QLM 797

  Fly   196 HIVYRIGTSPDYAPNLPMLFGEIVML---ASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRV-KL 256
            .:.:.  .:||..|:|..::.:...:   ...||:....|::.  .::::::|.   :::|. :|
  Rat   798 QLCWE--EAPDDRPSLDQIYTQFKSINQGKKTSVADSMLRMLE--KYSQSLEGL---VQERTEEL 855

  Fly   257 ECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFA 321
            |.||.:.|:||..::|..:|..:|                ..:|....:.:       .|||.|:
  Rat   856 ELERRKTERLLSQMLPPSVAHALK----------------MGTTVEPEYFD-------QVTIYFS 897

  Fly   322 DIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLP-ISRPQHATNC 385
            |||.||.:|:.....::|..||||:..||.:...:...:::.:||.|...|||| .:..:||...
  Rat   898 DIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETIGDAYMVASGLPRRNGNRHAAEI 962

  Fly   386 VNMGLQMIDAIRH--VREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGV 448
            .||.|:::....:  :|.|..:.:.:|.|:|:|..:.||:||...::.::.|.|..|:.|||.|:
  Rat   963 ANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1027

  Fly   449 AGRVHITKQTLDFL-----GDKFEVE-----QGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPR 503
            ..|:|:::.|:..|     |.|.:|.     :|:|           :|....:..|..:..|:|.
  Rat  1028 PYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKG-----------LEETYWLTGKTGFCRSLPT 1081

  Fly   504 VVECIEQNDP 513
            .:. |:..||
  Rat  1082 PLS-IQPGDP 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	31/161 (19%)
		CYCc	259..467	CDD:214485	61/215 (28%)
		Guanylate_cyc	311..469	CDD:278633	52/165 (32%)
		BASP1	510..667	CDD:283191	1/3 (33%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Gucy2e	NP_570093.2	PBP1_sensory_GC_DEF-like	71..445	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..556
		PK_GC-2D	554..824	CDD:270945	16/92 (17%)
		CYCc	861..1050	CDD:214485	58/211 (27%)
		Interaction with NCALD. /evidence=ECO:0000269\|PubMed:18178149	880..921		14/47 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810