DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac76E and ADCY7

DIOPT Version :9

Sequence 1:NP_001246838.1 Gene:Ac76E / 40180 FlyBaseID:FBgn0004852 Length:1312 Species:Drosophila melanogaster
Sequence 2:XP_011521137.1 Gene:ADCY7 / 113 HGNCID:238 Length:1086 Species:Homo sapiens


Alignment Length:1309 Identity:461/1309 - (35%)
Similarity:633/1309 - (48%) Gaps:297/1309 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 LSEQENGTTAEDIHLNDLYTRYRQRLRKS-LFRSGLLTSLLACVVSIIIGIVYG-----QHLVQT 111
            |:|.|.|...:     .||.:|:...:.. |..:.||.:..|||..|||....|     |.::..
Human     9 LNEGEEGPDQD-----ALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGM 68

  Fly   112 MLLVLAALISGSILTALQF-------PAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYA 169
            ..||||...:.|:|..::.       ...|.:.|..:|...|..|...|.||...::: |..::.
Human    69 AFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKAACAWEQV-PFFLFI 132

  Fly   170 LFLCIHSMLPISWPVSVVLALFMTAIHIVYRIG------TSPDYAPNLPMLFGEIVMLASASVSG 228
            :|: ::::||.|...:|.:....||.|::. :|      |:|.....|.:|...::.|. .:::|
Human   133 VFV-VYTLLPFSMRGAVAVGAVSTASHLLV-LGSLMGGFTTPSVRVGLQLLANAVIFLC-GNLTG 194

  Fly   229 LYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQR 293
            .:::.....|.......|...|:.|.||..|:.|||.|||||:||:|:..:|.:|:.::    :.
Human   195 AFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERL----KE 255

  Fly   294 AGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC 358
            .|.:.......||.|:|:||.||:||:||||.||.|:|..:..:||..||:|||:|||||:.|:|
Human   256 HGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANEC 320

  Fly   359 LRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVL 423
            :||||||||||||||||:|.|.||.|||.|||.|..||:.||||||::::||:|||:|||||||:
Human   321 MRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVI 385

  Fly   424 GLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESY 488
            ||||||:||||.||:|||.||:.||.||||||:.||..|...:|||.|.|..||.||.:..:.:|
Human   386 GLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTY 450

  Fly   489 LIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDE 553
            |::.|:               ...|                                |||     
Human   451 LVIDPR---------------SQQP--------------------------------PPP----- 463

  Fly   554 KMSPTSINSQEAPL---HAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKAN 615
                    ||..|.   .|.|...||:.:....|....|                     .|.|:
Human   464 --------SQHLPRPKGDAALKMRASVRMTRYLESWGAA---------------------RPFAH 499

  Fly   616 GGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAA 680
            ..||        |||                |..|:.:.|      ...|.||            
Human   500 LNHR--------ESV----------------SSGETHVPN------GRRPKSV------------ 522

  Fly   681 SNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKM 745
                     |:|.||.         .||..|.    :||.    ..:|:            ..:|
Human   523 ---------PQRHRRT---------PDRSMSP----KGRS----EDDSY------------DDEM 549

  Fly   746 TKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRN 810
            ...:|...:.||..:                           |..:|..||.....|.|      
Human   550 LSAIEGLSSTRPCCS---------------------------KSDDFYTFGSIFLEKGF------ 581

  Fly   811 TPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGS--LLASFVSLALFL-YLSN 872
               |..||..|....|.|..||.::|:.:.:|.::::....||..|  |:|..:.|.|.| :.:.
Human   582 ---EREYRLAPIPRARHDFACASLIFVCILLVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATK 643

  Fly   873 MS----VPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINY-TVPDGVSKEPS 932
            .|    ......:.:||      |.:...|||.:.|   :.|.|....::||. .:|..|.:.|.
Human   644 FSRCCPARGTLCTISER------VETQPLLRLTLAV---LTIGSLLTVAIINLPLMPFQVPELPV 699

  Fly   933 SNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLV 997
            .|:|.|.:  :|....:..|.:            |.:...|.:...|.|.|||.....|::.:.|
Human   700 GNETGLLA--ASSKTRALCEPL------------PYYTCSCVLGFIACSVFLRMSLEPKVVLLTV 750

  Fly   998 AVIAQVTVLGYSDLFE----------MYNDANITHGLP----LEIK---GFLLLLVIILVLHTLD 1045
            |::|.:.:...|..::          :......|.|.|    .::|   .|.|:|..|.:| ||.
Human   751 ALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLL-TLS 814

  Fly  1046 RQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVA 1110
            ||.:|..|.|.|||.|.|.|.||.|||..:|::||||:||||||.||:..:.:.:.||:||.||.
Human   815 RQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKLNEDWYHQSYDCVC 879

  Fly  1111 VMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGL- 1174
            |||||:|::|.||.|.||||:||||||||||||.|||:|||||||||:||||||.||||.|:|| 
Human   880 VMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLS 944

  Fly  1175 -RPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGV 1238
             ..|.|:....|..|        ::.::|||:|||||.||.|||.||..||||:|:|||||||||
Human   945 VASGHENQELERQHA--------HIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGV 1001

  Fly  1239 IGAQKPQYDIWSNTVNVASRMDSCGVMGRL------QTTENTAKILMTAGYECECRGLTYVKGKG 1297
            |||:|||||||.|||||||||:|.|.:|::      |.||.|..||...||.||||||..|||||
Human  1002 IGARKPQYDIWGNTVNVASRMESTGELGKIQVSLPFQVTEETCTILQGLGYSCECRGLINVKGKG 1066

  Fly  1298 NLVTYFVKT 1306
            .|.||||.|
Human  1067 ELRTYFVCT 1075

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac76ENP_001246838.1 AC_N <67..289 CDD:292831 64/240 (27%)
CYCc 259..467 CDD:214485 122/207 (59%)
Guanylate_cyc 311..469 CDD:278633 104/157 (66%)
BASP1 510..667 CDD:283191 24/159 (15%)
CYCc 1079..1283 CDD:214485 130/211 (62%)
Guanylate_cyc 1101..1305 CDD:278633 135/211 (64%)
ADCY7XP_011521137.1 AC_N <73..249 CDD:292831 47/179 (26%)
CYCc 224..429 CDD:214485 122/208 (59%)
Guanylate_cyc 270..432 CDD:278633 107/161 (66%)
DUF1053 485..592 CDD:283888 39/243 (16%)
CYCc 848..1052 CDD:214485 130/211 (62%)
Guanylate_cyc 871..1073 CDD:278633 134/209 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 273 1.000 Domainoid score I1788
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 733 1.000 Inparanoid score I607
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46595
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 1 1.000 - - FOG0002139
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1422
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.980

Return to query results.
Submit another query.