Protein Alignment Ac76E and ADCY5

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 1442
• Identity: 436/1442 - (30%)
• Similarity: 626/1442 - (43%)
• Gaps: 435/1442 - (30%)

  Fly     6 AETAKTGNGTNATANLIVKADGNATQPKAM------TSSAARMNDALSASLADLSE--QENGTTA 62
            |..|..|.|:.|.|   ..|.|...:|:::      .....|..|.|.|...:..|  .:.|::|
Human   130 APPAGGGGGSAAAA---ASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSA 191

  Fly    63 E------------------------------DIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVS 97
            :                              ...|..||.||..||.:|     .||.|:|.:|.
Human   192 DSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS-----SLTMLMAVLVL 251

  Fly    98 IIIGIVYGQH-----LVQTMLLVLAALISGSILTALQFPAVLSSPAA------ALA-FAIVTTFS 150
            :.: ::...|     |....|.||||.: |.||    ..|||.:.||      .|| :|::....
Human   252 VCL-VMLAFHAARPPLQLPYLAVLAAAV-GVIL----IMAVLCNRAAFHQDHMGLACYALIAVVL 310

  Fly   151 LGTIAAITGDELAPLPMYA---------LFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPD 206
            ...:..:    |.|.|..|         ....|:::||:....:|:..:.::|:|:...:.|:..
Human   311 AVQVVGL----LLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQ 371

  Fly   207 YAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVI 271
            ....|..|...:::.:..::.|:.....::.:..:....||..|:.|:..:.|.:|||:|||||:
Human   372 DQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVL 436

  Fly   272 PAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTAS 336
            |.::|.|:|..|..|..|             ..||::::|:|.||:||||||..||.|:|..||.
Human   437 PRHVAMEMKADINAKQED-------------MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQ 488

  Fly   337 DLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVRE 401
            :||.|||:||.|||::|.||.||||||||||||||||||.:|..||..||.||:.||:||..|||
Human   489 ELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVRE 553

  Fly   402 ATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKF 466
            .||:||:||:|||:|.|.|||||||||||||||:|||||||||:||.|||:||||.||::|...:
Human   554 VTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDY 618

  Fly   467 EVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHE 531
            |||.|.||.|:|||.:|.:|::||              :.|         |::.||
Human   619 EVEPGCGGERNAYLKEHSIETFLI--------------LRC---------TQKRKE--------- 651

  Fly   532 ATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVT 596
                                 ||.....:|.|.                               |
Human   652 ---------------------EKAMIAKMNRQR-------------------------------T 664

  Fly   597 EPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQ 661
            ..:.|         .|...|..|...:......|:|.          :...|.|.. .:..|| :
Human   665 NSIGH---------NPPHWGAERPFYNHLGGNQVSKE----------MKRMGFEDP-KDKNAQ-E 708

  Fly   662 SSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSG 726
            |:||..                    |..|...|.:..:.:    ||.||.
Human   709 SANPED--------------------EVDEFLGRAIDARSI----DRLRSE-------------- 735

  Fly   727 ESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFN 791
                    ||
Human   736 --------HV------------------------------------------------------- 737

  Fly   792 FNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGS 856
                      :.|.:.:|....|..|..|.|..|...:.||.::||.:..||:.::..::.:|..
Human   738 ----------RKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSF 792

  Fly   857 LLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLR-----------------LAMFV 904
            .|...:.|.|.:::|     .:::.......|.|.: |.:.:|                 ||.||
Human   793 YLTCSLLLTLVVFVS-----VIYSCVKLFPSPLQTL-SRKIVRSKMNSTLVGVFTITLVFLAAFV 851

  Fly   905 VV----------------NI---LISSCAVF-SVINYTVPD--GVSKEPSSNQTILESNFSSVFV 947
            .:                ||   .:::|.|. |.:||::.|  |....|..|     .||...|.
Human   852 NMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPN-----CNFPEYFT 911

  Fly   948 NSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAM--------LVAVIAQVT 1004
            .|.|                       :||.|.|.||:...|.||:.|        |:..:..||
Human   912 YSVL-----------------------LSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVT 953

  Fly  1005 VLGYSDL------FEMYNDA--------NITH----------------------GLPLEIKGFLL 1033
            :...:||      .:.:|:.        |:.|                      .:.|::...::
Human   954 LFDNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPII 1018

  Fly  1034 LLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLE-R 1097
            :.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||.|||..| |
Human  1019 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR 1083

  Fly  1098 STELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIK 1162
            :.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.:|..:||||
Human  1084 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIK 1148

  Fly  1163 TIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRI 1227
            ||.||||.||||.....|           :..:.::..|.:||:.||..:..||..||..|:::|
Human  1149 TIGSTYMAASGLNDSTYD-----------KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKI 1202

  Fly  1228 GLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTY 1292
            |||.|||:||||||:|||||||.|||||||||||.||..|:|.|.:..::|....|:.||||:..
Human  1203 GLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVK 1267

  Fly  1293 VKGKGNLVTYFV 1304
            |||||.::|||:
Human  1268 VKGKGEMMTYFL 1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	174/418 (42%)
		Guanylate_cyc	310..469	CDD:425528	109/158 (69%)
		Guanylate_cyc	1101..1305	CDD:425528	108/204 (53%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	81/358 (23%)
		Guanylate_cyc	460..643	CDD:425528	122/196 (62%)
		Adcy_cons_dom	668..761	CDD:461877	28/224 (13%)
		Guanylate_cyc	1087..1281	CDD:425528	108/204 (53%)