DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and ADCY3

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_011530791.1	Gene:	ADCY3 / 109	HGNCID:	234	Length:	1186	Species:	Homo sapiens

Alignment Length:	1332	Identity:	400/1332 - (30%)
Similarity:	601/1332 - (45%)	Gaps:	324/1332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLR-KSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSIL----- 125
            |.:||..|.:|.| ::|....:..:|..|.|.::..:|:....:.::.:....|:...||
Human    62 LENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCK 126

  Fly   126 --------TALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISW 182
                    |....|.||.....|..|:.:   .|....|....:.....::.:| .....||:|.
Human   127 KGLLPDRVTRRVLPYVLWLLITAQIFSYL---GLNFARAHAASDTVGWQVFFVF-SFFITLPLSL 187

  Fly   183 PVSVVLALFMTAIH-IVYRIGTSPDYAPNLP--MLFGEIV----MLASASVSGLYYRIMSDAAHN 240
            ...|::::....:| :|..:..:......|.  .|..||:    :...|...|:....|:|..|.
Human   188 SPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHR 252

  Fly   241 RTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLK--MADACQRAGGQASTSAT 303
            :.....|..:|.::.||.:.:|||.|:||::|.::|.|     |||  ..|..|:       ...
Human   253 KAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADE-----MLKDMKKDESQK-------DQQ 305

  Fly   304 RFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCY 368
            :|:.:::.||.||:|||||||.||.|||:.:|.:|||.||:||.|||::|.:...||||||||||
Human   306 QFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCY 370

  Fly   369 YCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVW 433
            ||:.|||..|..||...:.|||.|::||.:|||.|...||||:|:|||.||.||||.::||:|||
Human   371 YCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVW 435

  Fly   434 SDDVTLANHMESGGVAG----------------------RVHITKQTLDFLGDKFEVEQGEGGNR 476
            |.|||:||.||:||:.|                      ||||::.|:|.|..:|:||.|:||:|
Human   436 STDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLKGEFDVEPGDGGSR 500

  Fly   477 DAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLP 541
            ..||.:..:|:|||:..||                          |:|:|     ||.
Human   501 CDYLEEKGIETYLIIASKP--------------------------EVKKT-----ATQ------- 527

  Fly   542 VTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDG 606
                            ..:|....|..||.:|.:|               :.|:.|
Human   528 ----------------NGLNGSALPNGAPASSKSS---------------SPALIE--------- 552

  Fly   607 KNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPT 671
              .|||  ||....||  :.||...:..|...|.    ::|.........|:||  .||:...|
Human   553 --TKEP--NGSAHSSG--STSEKPEEQDAQLFPT----TLSHLPHSRCLPGSQA--DNPSFPNP- 604

  Fly   672 AAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHV 736
                                  ||:|.:|.|   |||
Human   605 ----------------------RRRLRLQDL---ADR---------------------------- 616

  Fly   737 TRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCF--NFNFFGPPT 799
                       .|:....:.....:....|::.         ||..:..:|..|  :..|..|..
Human   617 -----------VVDASEDEHELNQLLNEALLER---------ESAQVVKKRNTFLLSMRFMDPEM 661

  Fly   800 ELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSL 864
            |.:              |..:.:........|:.|:.|..|:|::::   :..|:.:.:...|..
Human   662 ETR--------------YSVEKEKQSGAAFSCSCVVLLCTALVEILI---DPWLMTNYVTFMVGE 709

  Fly   865 ALFLYLSNMSVPDVHASTTERNGPGQVVASSRYL-----------RLAMFVVV--NIL-ISSCAV 915
            .|.|.|:..|:    |:...|..|.::||.|.::           .||:|::|  |:: :.||..
Human   710 ILLLILTICSL----AAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQ 770

  Fly   916 FSVINYTVPDGVSKEPSSNQTI-LESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAA 979
            :    ||.|        ||.|. :|:.      .|.||:.:.:.            |...:||.|
Human   771 Y----YTGP--------SNATAGMETE------GSCLENPKYYN------------YVAVLSLIA 805

  Fly   980 ISAFLRSGFILKLIAMLV--AVIAQVTVLGYSDLFEMYNDANI-THGLPL----EIKGF------ 1031
            ....::...::||..||:  ..:|.:.:..:..:|:.|:.... .|.||:    :::||
Human   806 TIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNG 870

  Fly  1032 ---------------LLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLE 1081
                           :::.:::|..:...|..|.:|||.||||.::..::|.|..||..|:.|:.
Human   871 TDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVT 935

  Fly  1082 NILPAHVATHFL-HLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICD 1145
            |:||.|||.||| ..:|..|||.::|..:.|||||:||:.:||.|..:|..|:||||.|||||.|
Human   936 NMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISD 1000

  Fly  1146 FDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEE--HNVVILVEFAIAL 1208
            ||.||..|||..|.|||||.||||.|||:.|.......:.|..::|...|  .::..|.:||:|:
Human  1001 FDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAM 1065

  Fly  1209 MSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTEN 1273
            ...|.:||.:||..|.||||:|.|.|:||||||:||.||||.|||||||||:|.||||.:|..|.
Human  1066 KDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEE 1130

  Fly  1274 TAKILMTAGYECECRGLTYVKGKGNLVTYFVK 1305
            |..||...|:....||..:|||||.|:|:|:|
Human  1131 TQVILREYGFRFVRRGPIFVKGKGELLTFFLK 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	54/244 (22%)
		CYCc	259..467	CDD:214485	108/231 (47%)
		Guanylate_cyc	311..469	CDD:278633	94/179 (53%)
		BASP1	510..667	CDD:283191	30/156 (19%)
		CYCc	1079..1283	CDD:214485	109/206 (53%)
		Guanylate_cyc	1101..1305	CDD:278633	108/205 (53%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	56/256 (22%)
		CYCc	273..490	CDD:214485	108/228 (47%)
		Guanylate_cyc	310..516	CDD:278633	106/205 (52%)
		CYCc	925..1143	CDD:214485	113/217 (52%)
		Guanylate_cyc	956..1163	CDD:278633	109/207 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710