DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and ADCY1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	1284	Identity:	407/1284 - (31%)
Similarity:	595/1284 - (46%)	Gaps:	308/1284 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRYRQRLRKSLFRSGL-LTSLLACVVSI---------IIGIVYGQHLVQTMLLVLAALIS 121
            |..|:..|..||.::.....| :.||||..:::         ..|:..|.|.|..:|.:  ||:.
Human    45 LEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFL--ALLV 107

  Fly   122 GSILTALQFPAVLSSPAAALAFAIVTTFSL------------GTIAAITGDELAPLPMYALFLCI 174
            .:.:.:||.|.:......||.|::  ||:|            |:..|..|...|...::.|.|..
Human   108 VTNVRSLQVPQLQQVGQLALLFSL--TFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVT 170

  Fly   175 ---HSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFG-EIVMLASASVSGLYYRIMS 235
               :::||:...:::...|.:.|.|::......|...|.|....| ..::....::.|::.||::
Human   171 FVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILT 235

  Fly   236 DAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQAST 300
            :.:..:.....|:.||.|::||.|.|:||:||:|::|..:|.|:|.. .||..:..
Human   236 ERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED-FLKPPERI--------- 290

  Fly   301 SATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILG 365
                ||::::|||.||:|||||||.||.|:|..||.:|||.||:|||:||::|.||.|.||||||
Human   291 ----FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILG 351

  Fly   366 DCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQF 430
            |||||||||...:..||..||.|||.|||.|..|.|||.::::||:|:|||.||||||||||||:
Human   352 DCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQY 416

  Fly   431 DVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKP 495
            ||||:||||||.||:.|:.|:|||||.||..|...:|||.|.|..|:::|..|.:|::.|||
Human   417 DVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVP--- 478

  Fly   496 AYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSI 560
                                             ||.                     .|:.|..|
Human   479 ---------------------------------SHR---------------------RKIFPGLI 489

  Fly   561 NSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSA 625
            .|...|       |..|..|.:          ..:...|||
Human   490 LSDIKP-------AKRMKFKTV----------CYLLVQLMH------------------------ 513

  Fly   626 ASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAP 690
                ..|.....:|                                        .||.:|..:..
Human   514 ----CRKMFKAEIP----------------------------------------FSNVMTCEDDD 534

  Fly   691 ERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGAD 755
            :|...:.:.:.|     |.||                ||.::..:.|   |.:::.:|:.
Human   535 KRRALRTASEKL-----RNRS----------------SFSTNVVYTT---PGTRVNRYIS----- 570

  Fly   756 RPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQ 820
                                .::|:.....|....||           ||:.|::..||..|...
Human   571 --------------------RLLEARQTELEMADLNF-----------FTLKYKHVEREQKYHQL 604

  Fly   821 PDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASF-----VSLALFLYLSNMSVPDVHA 880
            .|.:|...::...:|.....:|.|::...::.:|  ||..|     |:..|:|:::.:..
Human   605 QDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVL--LLLVFCICFLVACVLYLHITRVQC----- 662

  Fly   881 STTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSV 945
                  .||.:....|.: |.:|:||  ||.|.|...|:. .:|...|.:|:|:..:|.|.....
Human   663 ------FPGCLTIQIRTV-LCIFIVV--LIYSVAQGCVVG-CLPWAWSSKPNSSLVVLSSGGQRT 717

  Fly   946 FVNSTLEDVQLWEIDYAIPIAPV-----FLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTV 1005
                            |:|..|.     .|.||.:....::.|.|...:.|:|.:.....:.:.|
Human   718 ----------------ALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILV 766

  Fly  1006 L---GYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQE 1067
            |   ||:     ........|...|....:||....|.||.  ||.:...|.|:||.|:.:.|:|
Human   767 LELSGYT-----RTGGGAVSGRSYEPIVAILLFSCALALHA--RQVDIRLRLDYLWAAQAEEERE 824

  Fly  1068 EVETMRGINKILLENILPAHVATHFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQ 1131
            ::|.::..|:.:|.|:||||||.|||... |:.:||::|||.|.||||||||:.:||.|.|.|..
Human   825 DMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNM 889

  Fly  1132 GLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEH 1196
            |:||||||||||.|||:|:.|..:..|||||||.||||.|.||.|      ||.:.|  |::...
Human   890 GVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAP------TSGTKA--KKSISS 946

  Fly  1197 NVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDS 1261
            ::..|.:|||.:..:||.||.:|:..|.||:|:|.|||:||||||::||||||.|||||||||||
Human   947 HLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDS 1011

  Fly  1262 CGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDG 1310
            .||.||:|.||...::|....|...|||...|||||.::|||::...||
Human  1012 TGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDG 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	63/247 (26%)
		CYCc	259..467	CDD:214485	117/207 (57%)
		Guanylate_cyc	311..469	CDD:278633	103/157 (66%)
		BASP1	510..667	CDD:283191	15/156 (10%)
		CYCc	1079..1283	CDD:214485	114/204 (56%)
		Guanylate_cyc	1101..1305	CDD:278633	114/203 (56%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831	33/144 (23%)
		CYCc	258..453	CDD:214485	117/208 (56%)
		Guanylate_cyc	294..476	CDD:278633	111/181 (61%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		8/71 (11%)
		CYCc	826..1037	CDD:214485	117/218 (54%)
		Guanylate_cyc	859..1056	CDD:278633	114/204 (56%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710