Protein Alignment Ac76E and Adcy3

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: NP_612178.2
• Gene: Adcy3 / 104111
• MGIID: 99675
• Length: 1145
• Species: Mus musculus
• Alignment Length: 1312
• Identity: 392/1312 - (29%)
• Similarity: 590/1312 - (44%)
• Gaps: 325/1312 - (24%)

  Fly    67 LNDLYTRYRQRLR-KSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTAL-- 128
            |.:||..|.:|.| ::|....:..:|..|.|.::..:|:....:..:::....|:...||..|
Mouse    62 LENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGFGLVLDIILFVLCK 126

  Fly   129 -----------QFPAVLSSPAAALAFAIV-TTFSLGTIAAITGDELAPLPMYALFLCIHSMLPIS 181
                       ..|.:|....:|..|:.: ..||....|:.|....| ..:::.|:    .||:|
Mouse   127 KGLLPDRVSRKVVPYLLWLLISAQIFSYLGLNFSRAHAASDTVGWQA-FFVFSFFI----TLPLS 186

  Fly   182 WPVSVVLALFMTAIHIVYRIGTS-----PDYAPNLPML---FGEIVMLASASVSGLYYRIMSDAA 238
            ....|::::....:|.:. :|.:     .|....:.:|   ...:.:...|.:.|:....|:|..
Mouse   187 LSPIVIISVVSCVVHTLV-LGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRK 250

  Fly   239 HNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLK--MADACQRAGGQASTS 301
            |.:.....|..:|.::.||.:.:|||.|:||::|.::|.|     |||  ..|..|:       .
Mouse   251 HRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADE-----MLKDMKKDESQK-------D 303

  Fly   302 ATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGD 366
            ..:|:.:::.||.||:|||||||.||.|||:.:|.:|||.||:||.|||::|.:...||||||||
Mouse   304 QQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGD 368

  Fly   367 CYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFD 431
            ||||:.|||..|..||...:.|||.|::||.:|||.|...||||:|:|||.||.||||.::||:|
Mouse   369 CYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYD 433

  Fly   432 VWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPA 496
            |||.|||:||.||:||:.|||||::.|:|.|..:|:||.|:||:|..||.:..:|:|||:..||
Mouse   434 VWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKP- 497

  Fly   497 YTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSIN 561
                                     |:|:|.|:                             .:|
Mouse   498 -------------------------EVKKTAQN-----------------------------GLN 508

  Fly   562 SQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAA 626
            ....|..||.:|..|               :.|:.|           .|||..:....||....|
Mouse   509 GSAVPNGAPASSKPS---------------SPALIE-----------TKEPNGSAHASGSTSEEA 547

  Fly   627 SESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPE 691
            .|.                             :||:.||:...|
Mouse   548 EEQ-----------------------------EAQADNPSFPNP--------------------- 562

  Fly   692 RSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADR 756
              ||:|.:|.|   |||                                       .|:....:.
Mouse   563 --RRRLRLQDL---ADR---------------------------------------VVDASEDEH 583

  Fly   757 PFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQP 821
            ....:....|::.         ||..:..:|..|            ..||.:.:...|..|..:.
Mouse   584 ELNQLLNEALLER---------ESAQVVKKRNTF------------LLTMRFMDPEMETRYSVEK 627

  Fly   822 DTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERN 886
            :........|:.|:....|:|::::   :..|:.:.:...|...|.|.|:..|:    |:...|:
Mouse   628 EKQSGAAFSCSCVVLFCTAMVEILI---DPWLMTNYVTFVVGEVLLLILTICSM----AAIFPRS 685

  Fly   887 GPGQVVASSRYL-----------RLAMFVVV--NIL-ISSCAVFSVINYTVPDGVSKEPSSNQTI 937
            .|.::||.|.::           .||:|::|  |:: :.||..:.:..|.:..|:
Mouse   686 FPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNMTAGM---------- 740

  Fly   938 LESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFL-YCCAISLAAISAFLRSGFILKLIAMLVAVIA 1001
                                |:|......|.:. |...:||.|....::...::||..||: |..
Mouse   741 --------------------ELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLL-VTG 784

  Fly  1002 QVTVL---GYSDLFEMYNDANI-----------------THGL----------PLEIKGFLLLLV 1036
            .||.|   .:..:|:.|:....                 |.||          |.:....:::.|
Mouse   785 AVTALNLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFV 849

  Fly  1037 IILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFL-HLERSTE 1100
            ::|..:...|..|.:|||.||||.::..::|.|..||..|:.|:.|:||.|||.||| ..:|..|
Mouse   850 MMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEE 914

  Fly  1101 LYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIA 1165
            ||.:||..:.|||||:||:.:||.|..:|..|:||||.|||||.|||.||..|||..|.|||||.
Mouse   915 LYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIG 979

  Fly  1166 STYMCASGLRPGKEDGATSRSFADEKRTEE--HNVVILVEFAIALMSILDSINRESFQRFRLRIG 1228
            ||||.|||:.|.......:.|..:||..:|  .::..|.:||:|:...|.:||.:||..|.||||
Mouse   980 STYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIG 1044

  Fly  1229 LNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYV 1293
            :|.|.|:||||||:||.||||.|||||||||:|.||||.:|..|.|..||...|:....||..:|
Mouse  1045 MNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFV 1109

  Fly  1294 KGKGNLVTYFVK 1305
            ||||.|:|:|:|
Mouse  1110 KGKGELLTFFLK 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	54/246 (22%)
		CYCc	259..467	CDD:214485	108/209 (52%)
		Guanylate_cyc	311..469	CDD:278633	94/157 (60%)
		BASP1	510..667	CDD:283191	23/156 (15%)
		CYCc	1079..1283	CDD:214485	111/206 (54%)
		Guanylate_cyc	1101..1305	CDD:278633	110/205 (54%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	56/258 (22%)
		Guanylate_cyc	310..494	CDD:306677	106/183 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..564		21/166 (13%)
		Guanylate_cyc	915..1122	CDD:306677	111/207 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710