DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac76E and Adcy4

DIOPT Version :9

Sequence 1:NP_001246838.1 Gene:Ac76E / 40180 FlyBaseID:FBgn0004852 Length:1312 Species:Drosophila melanogaster
Sequence 2:NP_001348533.1 Gene:Adcy4 / 104110 MGIID:99674 Length:1077 Species:Mus musculus


Alignment Length:1331 Identity:433/1331 - (32%)
Similarity:624/1331 - (46%) Gaps:362/1331 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 AEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGI-----VYGQHLVQT---MLLVLAA 118
            :||:.....|:..:|        ..||..||..|:..::.:     ..|:.|...   :..||.|
Mouse    12 SEDLFYETYYSLSQQ--------YPLLILLLVIVLCALVALPAVAWASGRELTSDPSFLTTVLCA 68

  Fly   119 LISGSILTAL----QFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFL----CIH 175
            |...|:|..|    |.....:.|.:.|.:  |...:||.....||..::.....:.||    .::
Mouse    69 LGGFSLLLGLASREQQLQRWTRPLSGLIW--VALLALGYGFLFTGGVVSAWDQVSFFLFIIFTVY 131

  Fly   176 SMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPN-----LPMLFGEIVMLASASVSGLYYRIMS 235
            :|||:....:....:..:..|::. :|....:.|.     ||.|....|:....:|.|.|::.:.
Mouse   132 AMLPLGMRDAAAAGVISSLSHLLV-LGLYLGWQPESQRALLPQLAANAVLFLCGNVVGAYHKALM 195

  Fly   236 DAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQAS- 299
            :.|...|.....:.:..|.:|:.|::.||.||||::|||:|.|:|..||.::      ..||.| 
Mouse   196 ERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARL------QAGQRSR 254

  Fly   300 -TSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKI 363
             .:...||.|:|:||..|::|:||||.||.|:|..:..:||..||:|||:|||||:|::|:||||
Mouse   255 PENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKI 319

  Fly   364 LGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKW 428
            ||||||||||||:|.|.||.|||.|||.|..|||.:|.|||::::||:|:|:|:|||||:||:||
Mouse   320 LGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKW 384

  Fly   429 QFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPP 493
            |:||||.|||||||||:|||.||||||..||..|...:.||:.:..:||.||.:....:||::.|
Mouse   385 QYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADTEHRDPYLRELGEPTYLVIDP 449

  Fly   494 KPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPT 558
            :                                                                
Mouse   450 R---------------------------------------------------------------- 450

  Fly   559 SINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGD 623
                                    :|||||                                   
Mouse   451 ------------------------AEEEDE----------------------------------- 456

  Fly   624 SAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAE 688
                                                                             
Mouse   457 ----------------------------------------------------------------- 456

  Fly   689 APERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWG 753
                   |.:.:||:|                          |..||..  |||..||:|:|.||
Mouse   457 -------KGTAKGLLS--------------------------SLEGHTM--RPSLLMTRYLESWG 486

  Fly   754 ADRPFANIA--ESKLVKNIGLASIAM--------------IESNLLPPERKCF------------ 790
            |.:|||:::  :|.:..:..|...|.              ::..|...:.|.|            
Mouse   487 AAKPFAHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQW 551

  Fly   791 ----NFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNL 851
                :||.         .|:::|....|..||......|::...|.|::|||...:|::|.....
Mouse   552 KQSKDFNL---------LTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRPP 607

  Fly   852 ALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGP---------GQVVASSRYLRLAMFVVVN 907
            ||:.:...:|:...|.|::....    |.:...:.||         ..:||:....|:|:.....
Mouse   608 ALIITYSITFLLFFLLLFVCFSE----HLTKCVQKGPKMLHWLPALSVLVATRPGFRVALGTATI 668

  Fly   908 ILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPI------- 965
            :|:.:.|:.|::...|        ||:...|.||.|||..|::      ||:..::|:       
Mouse   669 LLVFTMAIASLLFLPV--------SSDCLFLASNVSSVTFNAS------WEMPGSLPLISIPLIS 719

  Fly   966 APVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVLGYSD----------LFEMYNDANI 1020
            .|..::||.:...:.|.||...|.|||:.:|:.::|..::..:|.          |::..:|:. 
Mouse   720 IPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLSDCLIARLYQSPSDSR- 783

  Fly  1021 THGLPLEIK--GFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENI 1083
             .|:..|.|  |.:...:....|..|.||.||..|.|||||.||:.|:||.|||..:.::||||:
Mouse   784 -PGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENV 847

  Fly  1084 LPAHVATHFLHLERSTE-LYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFD 1147
            ||||||..|:...|..| |||:||.||.|:|||:|::||||.|:::|.:||||||||||||.|||
Mouse   848 LPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFD 912

  Fly  1148 KLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATS--RSFADEKRTEEHNVVILVEFAIALMS 1210
            :||.||||||:||||||.||||.|:||      .|||  .:..|.:|:..| :..:||||:||.|
Mouse   913 ELLSKPKFSGVEKIKTIGSTYMAATGL------NATSGQDTQQDSERSCSH-LGTMVEFAVALGS 970

  Fly  1211 ILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTA 1275
            .|..||:.||..||||:|||||||:||||||||||||||.|||||||||:|.||:|::|.||.||
Mouse   971 KLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETA 1035

  Fly  1276 KILMTAGYECECRGLTYVKGKGNLVTYFVKT 1306
            :.|.:.||.|..||...|||||.|.|||:.|
Mouse  1036 RALQSLGYTCYSRGSIKVKGKGELCTYFLNT 1066

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac76ENP_001246838.1 AC_N <67..289 CDD:292831 58/242 (24%)
CYCc 259..467 CDD:214485 122/209 (58%)
Guanylate_cyc 311..469 CDD:278633 100/157 (64%)
BASP1 510..667 CDD:283191 5/156 (3%)
CYCc 1079..1283 CDD:214485 129/206 (63%)
Guanylate_cyc 1101..1305 CDD:278633 130/205 (63%)
Adcy4NP_001348533.1 AC_N <115..246 CDD:318454 34/131 (26%)
Guanylate_cyc 264..418 CDD:306677 101/153 (66%)
DUF1053 479..580 CDD:368844 22/109 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..524 2/21 (10%)
Guanylate_cyc 866..1065 CDD:306677 130/205 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 274 1.000 Domainoid score I1757
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 729 1.000 Inparanoid score I615
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46595
OrthoDB 1 1.010 - - D181177at33208
OrthoFinder 1 1.000 - - FOG0002139
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4464
SonicParanoid 1 1.000 - - X1422
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.870

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