DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and gucy1a1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_002933521.3	Gene:	gucy1a1 / 100496677	XenbaseID:	XB-GENE-983418	Length:	700	Species:	Xenopus tropicalis

Alignment Length:	552	Identity:	117/552 - (21%)
Similarity:	200/552 - (36%)	Gaps:	186/552 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EQEN--GTTAEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLAC------VVSIIIGIV------YG 105
            :|.|  |...|.:         ::.|...|||        .|      |:.::.|.:      :|
Frog   138 DQSNAAGVPVEHV---------KETLGDELFR--------ICYEEDEHVLQVVAGTLKDFLNSFG 185

  Fly   106 QHLVQT----MLLVLAALISGSIL-------------------TALQFPAVLSSPAAALAFAIVT 147
            .||.|:    .|...:.|..||||                   |.|..|.::.: ||.:.|....
Frog   186 THLKQSGQSRTLEECSGLEEGSILCLEKDQDYLNVYYFFPNNITPLILPGIIRA-AACILFETEV 249

  Fly   148 TFSLGTIAAITGDE-------------------LAP-----------------LPMYALFLCIHS 176
            ...|...:...|::                   |:|                 .|.:.:|....:
Frog   250 EVRLIPHSCSDGNDFIKEPYLLYSVQVKNTRPSLSPSKPQSYVVIPASIFCKTFPFHFMFDKDMT 314

  Fly   177 MLPI--------SW------------------PVSVVLALFMTAIHI--VYRIGT---SPDYAPN 210
            ||.|        :|                  .:|...:..:|.:::  |.|:.|   :.|....
Frog   315 MLQIGNGVKRLLNWRDIPRKSTFEEYFEILSPKISCTFSGILTMLNMQFVIRVKTWDSTTDQTSK 379

  Fly   211 LPMLFGEIVMLASASV-----------------SGLYYRIMSD-AAHNRTVDGTRTGIEQRVK-- 255
            ...|.|:::.:..:|.                 .|||   :|| ..||...|...||.:.|.:
Frog   380 AMNLKGQMIYVFESSAILFLGSPCVDRLEDFTGQGLY---LSDIPIHNALRDVVLTGEQARAQDG 441

  Fly   256 ------------------LECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSA 302
                              ||.|:::...||.|:.|..:|.::                .|..|
Frog   442 LKKRLGKLKATLEQAHQALEEEKKKTVDLLFSIFPGEVAQQL----------------WQGET-- 488

  Fly   303 TRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDC 367
                 :..::..|||:||:|||.||.:.|..:...::..|::|:..||....|....:::.:||.
Frog   489 -----VQAKKFNNVTMLFSDIVGFTAICSHCSPMQVITMLSELYTLFDFQCGELDVYKVETIGDA 548

  Fly   368 YYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDV 432
            |....||......||.....|.|:|::....|....|..:.||||:|:|:|:.||:|:|..::.:
Frog   549 YCVAGGLHKESETHAFQVALMALKMMELSDEVMSPHGEQIKMRIGLHSGSVVAGVVGVRMPRYCL 613

  Fly   433 WSDDVTLANHMESGGVAGRVHITKQTLDFLGD 464
            :.::|||||..||..|..:::::..|...|.|
Frog   614 FGNNVTLANKFESCSVPRKINVSPTTYRLLKD 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	61/361 (17%)
		CYCc	259..467	CDD:214485	58/206 (28%)
		Guanylate_cyc	311..469	CDD:278633	50/154 (32%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gucy1a1	XP_002933521.3	HNOBA	294..483	CDD:400168	34/191 (18%)
gucy1a1	XP_002933521.3	Guanylate_cyc	489..676	CDD:306677	50/157 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910