Protein Alignment Ac76E and adcy6

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_002935166.2
• Gene: adcy6 / 100493933
• XenbaseID: XB-GENE-1011902
• Length: 1239
• Species: Xenopus tropicalis
• Alignment Length: 1327
• Identity: 402/1327 - (30%)
• Similarity: 595/1327 - (44%)
• Gaps: 382/1327 - (28%)

  Fly    67 LNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQ-HLVQTMLLVLAALISGSILTAL-- 128
            |..||.||..::.:|.....:...:|.|:|.:|....:|: .:|...:|.:|..:..|::...
 Frog   208 LERLYQRYFFQMNQSSLTMLMGALVLVCLVMLIFHCTHGEPQVVYVSVLAVAMALFLSLMVVCNR 272

  Fly   129 -----QFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFL--CIHSMLPISWPVSV 186
                 .:..::|....|:.||:..   || :..:|....:....:::|.  .|:::||:....:|
 Frog   273 NGFHQDYMWIVSYLVIAVLFAVQV---LG-VLMVTPRSASEGIWWSVFFIYIIYTLLPVRMRAAV 333

  Fly   187 VLALFMTAIHIV--YRIGTSPDYAPNLPMLF------GEIVMLASASVSGLYYRIMSDAAHNRTV 243
            :..|.::::|::  :|:        ||..:|      ..:::....::.|:.....::.:..:..
 Frog   334 LSGLILSSLHLIISWRL--------NLTDIFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAF 390

  Fly   244 DGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHEL 308
            ..||..|:.|:.|:.|.:|||:|||||:|.::|.|:|..|..|..|             ..||::
 Frog   391 QETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKEDINTKKED-------------MMFHKI 442

  Fly   309 HVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSG 373
            ::|:|.||:||||||..||.|:|..||.:||.|||:||.|||::|.||.||||||||||||||||
 Frog   443 YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSG 507

  Fly   374 LPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVT 438
            ||.:|..||..||.||:.||:||..|||.||:||:||:|||:|.|.|||||||||||||||:|||
 Frog   508 LPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVT 572

  Fly   439 LANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPR 503
            ||||||:||.|||:|||..||.:|...:|||.|.||.|:|||.:|.::::|
 Frog   573 LANHMEAGGKAGRIHITSATLKYLNGDYEVEPGNGGERNAYLKEHDIKTFL-------------- 623

  Fly   504 VVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLH 568
            |..|         :::.||.|
 Frog   624 VTGC---------SQKRKEEK-------------------------------------------- 635

  Fly   569 APLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKS 633
                                         .:|.|.|      ..:||
 Frog   636 -----------------------------AMMARLQ------RARAN------------------ 647

  Fly   634 AALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLS 698
                                ||.|                          ||....||||
 Frog   648 --------------------SNEG--------------------------LTRVWVPERS----- 661

  Fly   699 VQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAE 763
                   ..|.:.|.||   |::.|  .||.:.:........|..::.::
 Frog   662 -------FPRNKGSKAF---RQMGI--DESSKDNRNTQEALNPEDEVDEF--------------- 699

  Fly   764 SKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFD 828
              |.:.|...||..:..:                  .:|.|.:.::....|..|..:.|..|...
 Frog   700 --LARAIDARSIDQLRKD------------------HVKKFLLTFQTPDLEKKYSKKVDDRFGGY 744

  Fly   829 LICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVA 893
            :.|..::|..:..:|:::...:..:||...:.|:.||..|::
 Frog   745 VTCTLLVFCFICFIQIVIFPHSFLMLGVYTSVFIILASILFV----------------------- 786

  Fly   894 SSRYLRLAMFVVVNILISSCAVFSVINY--TVPDGVSK---EPSSNQTILE-----SNFSSVFVN 948
                               ||::|.|..  ....|||:   :..:|.|::.     ..|:|.|||
 Frog   787 -------------------CAIYSCIKLFPAALQGVSRKIVQSRTNSTLIGILTILLVFTSAFVN 832

  Fly   949 ------STLEDVQLWEIDYAIPIAPV-----------------------------FLYCCAISLA 978
                  .:|.|....|::.:.....|                             |.|...:||.
 Frog   833 MFACNHRSLTDCAGQELNISYKFVNVCHLRMLNYSLSMDSPPCDSDKPLCNFPEYFNYSILLSLL 897

  Fly   979 AISAFLRSGFILKLIAMLVAVIAQVTVLGYSD--LFEMYNDANITHGLPLEIKGFL--------- 1032
            |.|.||:...|.||..||...|..:.::...:  ||:.|:.....:.||:...|.:
 Frog   898 ACSVFLQISSIGKLALMLFIQILYIVIVEGPEVVLFDNYDLLVTVNALPINGTGDIEECLPSSKI 962

  Fly  1033 --------LLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVA 1089
                    :|.|.:|.|:...:|.|..||.|||||.:...|:||:|.::..|:.||.||||..||
 Frog   963 ALKFVTPVILTVFVLALYLHAQQVESTARLDFLWKLQATGEKEEMEQLQAYNRRLLHNILPKDVA 1027

  Fly  1090 THFLHLE-RSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKP 1153
            .|||..| |:.|||::|..|||||||||.|:.|||.|.:.|.:|:||||||||||.|||:::.:.
 Frog  1028 AHFLAREHRNDELYYQSCECVAVMFASICNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEE 1092

  Fly  1154 KFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIALMSILDSINRE 1218
            ||..:||||||.||||.||||        ...::..|.:|   ::..|.::|:.|...:..||..
 Frog  1093 KFKQLEKIKTIGSTYMAASGL--------NDTTYDKEGKT---HITALADYAMKLREQMKYINEH 1146

  Fly  1219 SFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGY 1283
            ||..|:::||||.|||:||||||:|||||||.|||||||||||.|:...:|.|.:..::|...||
 Frog  1147 SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGLPDCIQVTTDLYQVLAAKGY 1211

  Fly  1284 ECECRGLTYVKGKGNLVTYFVKTPFDG 1310
            :.||||:..|||||.:.|||:.   ||
 Frog  1212 QMECRGVIKVKGKGEMTTYFLN---DG 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	163/415 (39%)
		Guanylate_cyc	310..469	CDD:425528	108/158 (68%)
		Guanylate_cyc	1101..1305	CDD:425528	107/203 (53%)
adcy6	XP_002935166.2	AC_N	89..440	CDD:318454	55/256 (21%)
		Guanylate_cyc	442..626	CDD:425528	120/197 (61%)
		Adcy_cons_dom	656..741	CDD:461877	22/136 (16%)
		Guanylate_cyc	1040..1233	CDD:425528	107/203 (53%)