Protein Alignment Ac76E and adcy9

DIOPT Version :9

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_003201145.2
• Gene: adcy9 / 100333702
• ZFINID: ZDB-GENE-050208-455
• Length: 1392
• Species: Danio rerio
• Alignment Length: 1468
• Identity: 383/1468 - (26%)
• Similarity: 594/1468 - (40%)
• Gaps: 417/1468 - (28%)

  Fly    16 NATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLND------LYTRY 74
            |.:.|..|:.:.:...|...:|...:.:.:.|.|..:|.......|    ||::      |:.|.
Zfish    29 NDSHNQQVRPNQSVDHPDMSSSKPCKYSISSSCSSGELGVPRAVMT----HLSNPRRVPPLFERS 89

  Fly    75 RQRLRKSLFRSGLLTSLLAC--------------------VVSIIIGIVYG---------QHLVQ 110
            ..:.....|.|.:|..  ||                    ..:::.||.:|         ..||.
Zfish    90 AAQCWDPKFDSSILEE--ACRERCFPQMQRRFRYILFYLATAALLWGIYFGINSSRCEPTNFLVP 152

  Fly   111 TMLLVLAALI----------------SGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITG 159
            |...::..|:                :..:||.:.|...|:.......||...:.        ..
Zfish   153 TAGFLILCLVLLWFTFTKPYSRYYNHTSFLLTVIMFGITLAPQTQTAHFAHYDSH--------RA 209

  Fly   160 DELAPLPMY----------------ALFLCIHSMLPISWPVSVVLALFMTA-------IHIVY-- 199
            |..:|||:|                .:.|.::|:|.:....||:|.|..:.       :|:..
Zfish   210 DNQSPLPVYQNASCISPVGTFSLCMEVLLLLYSVLHLPLYASVLLGLLYSVLYEALGWLHLAQLD 274

  Fly   200 --RIGTSPDYAPNLPMLF-GEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECERE 261
              .:|:....:..|..|. |:.::...|.|.|::..|||:.....|.......|.....||.|:.
Zfish   275 ESYVGSREGISGTLSWLGPGKFLLHLCAHVVGIHIFIMSEVRSRSTFLKVGQAIMHGKDLEVEKA 339

  Fly   262 QQEQLLLSVIPAYIAAEVKRSIMLKMAD-------------ACQRAGGQASTSATR--------- 304
            .:|:::.||:|..:|.|     ::|..|             .|..|...|.||::.
Zfish   340 LKERMIHSVMPRSVADE-----LMKQGDEESESSGKRYSAGTCSVAAAAAVTSSSPKSHKRKKNS 399

  Fly   305 -------FHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIK 362
                   |...:::|...|:|||||||.||.:|::.:|..||..|||||||||::.:...|.:|.
Zfish   400 IPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTSCEKIS 464

  Fly   363 ILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRK 427
            .||||||||:|.|.....||..||.|||.||.||....:.....|:||:|:|||.||||:||:::
Zfish   465 TLGDCYYCVAGCPEPLTDHAYCCVEMGLGMIQAIEQFCQEMSETVNMRVGVHTGTVLCGILGMKR 529

  Fly   428 WQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVP 492
            ::|||||:||.|||.||..||||:||:::.|..||.|::|.|.|....|    ..|.|...|
Zfish   530 FKFDVWSNDVNLANLMEQLGVAGKVHLSEVTAGFLDDRYEREDGRVIER----VGHSVTDQL--- 587

  Fly   493 PKPAYTYSV-----------------PRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLL 540
             |...||.:                 ....|.:..:..:.|.:.|..:....|||....    .:
Zfish   588 -KGLKTYLISGRKLGSQCGCSQLSLGQEFGETLSPSSNTHTPDHTHCVIAEPQSHGKAG----FM 647

  Fly   541 PVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQD 605
            |.:::     :|...:||:                              ||||          |:
Zfish   648 PCSIS-----IDVVDNPTT------------------------------DEAT----------QN 667

  Fly   606 GKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLS-MSGSESGISNSGAQAQSSNPASVT 669
            |..| |.:||.....:|.|..:            .:.||| :.....|:|      |||....:.
Zfish   668 GCQD-EHRANSSKFPAGRSPKT------------LNGLLSPLCEERVGVS------QSSLCDKLQ 713

  Fly   670 PTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAG 734
            ....:.||..|      ||..:.|    ::..|.|...|.:|...|:|
Zfish   714 EKDRSWAGSLA------AEGKDHS----AILPLRSKNFREKSDAHFVE----------------- 751

  Fly   735 HVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPT 799
                                     .|.|..|:|:.                       ||.||
Zfish   752 -------------------------VIKEDSLMKDY-----------------------FFKPP- 767

  Fly   800 ELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSL 864
             :...::.:.....|:.||    |.:...:       ::...||.....:..:||..||:..|.|
Zfish   768 -INKLSLNFLEKSLESAYR----TSYHEQV-------MNHVPVQTFASPVFSSLLDVLLSCTVFL 820

  Fly   865 AL----FLY-LSNMSVPDVHASTTERNGPGQVVASSRYLRL--AMFVVVNILISSCAVF------ 916
            ||    ||| |.:|..|               :|::..|.:  |:..:|::|:|...:|
Zfish   821 ALTMACFLYPLVSMQTP---------------LAATLGLAITAALLELVSLLLSIRMIFCLDDVQ 870

  Fly   917 -------SVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLW-EIDYA--IPIAPVFLY 971
                   .:::..||..|              ..:|.|  :|..|.:: .:.|:  :||......
Zfish   871 NCSRILLKLVSGWVPRHV--------------IGAVLV--SLPAVSVFSHLAYSLQLPIQVTMFL 919

  Fly   972 CCAISLAAI--------SAFLRSGFI----LKLIAMLVAV-------------------IAQVTV 1005
            |||:.:|.|        |.::||...    |.|:.:|.:.                   .|||.:
Zfish   920 CCALIIAIIQYCTFCQLSFWMRSALATVVGLSLLILLYSASIRTSATDAFPNFGNMSNQSAQVDL 984

  Fly  1006 LGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVE 1070
            ||.|      |.|.....| |.::..|...:::|::..|:|:.|...|..:....:....:.:::
Zfish   985 LGES------NSAPTALDL-LVLETVLSFFLLLLLVWFLNREFEVSYRLHYHGNVEADKHRIKIQ 1042

  Fly  1071 TMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLEC 1135
            |||.....||.||:|.|||...    :..:.|.:::..|.|:||||.|:.|||:|:  .:.|.||
Zfish  1043 TMRDQADWLLRNIIPIHVAEQL----KVNQSYSKNHDNVGVIFASIVNFSEFYEES--YEGGKEC 1101

  Fly  1136 LRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVI 1200
            .|:|||:|.|||:||.:|.||.:||||||.:|||.||||. |::        ..|:.....::..
Zfish  1102 YRVLNELIGDFDELLRQPAFSNVEKIKTIGATYMAASGLN-GQQ--------CQEQPHPHAHLCA 1157

  Fly  1201 LVEFAIALMSILDSINRESFQ-RFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGV 1264
            |.:||:.:|.::|..|:.... :|:||||.||||:.|||||..|..||||.:|||:||||||.||
Zfish  1158 LFDFALEMMRVVDDFNKNMLGFKFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGV 1222

  Fly  1265 MGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTY 1302
            ..|:|.:|.:..:|....|..:.||...|||||.:.||
Zfish  1223 ECRIQVSEESHCVLSRMNYAFDYRGTVNVKGKGQMRTY 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	56/300 (19%)
		CYCc	259..467	CDD:214485	97/236 (41%)
		Guanylate_cyc	311..469	CDD:278633	83/157 (53%)
		BASP1	510..667	CDD:283191	29/157 (18%)
		CYCc	1079..1283	CDD:214485	91/204 (45%)
		Guanylate_cyc	1101..1305	CDD:278633	93/203 (46%)
adcy9	XP_003201145.2	CYCc	337..570	CDD:214485	97/237 (41%)
		Guanylate_cyc	412..597	CDD:278633	92/192 (48%)
		CYCc	1044..1244	CDD:214485	94/214 (44%)
		Guanylate_cyc	1070..1262	CDD:278633	93/202 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910