Protein Alignment Ac76E and adcy9

DIOPT Version :10

• Sequence 1: NP_001246838.1
• Gene: Ac76E / 40180
• FlyBaseID: FBgn0004852
• Length: 1312
• Species: Drosophila melanogaster
• Sequence 2: XP_003201145.3
• Gene: adcy9 / 100333702
• ZFINID: ZDB-GENE-050208-455
• Length: 1392
• Species: Danio rerio
• Alignment Length: 1460
• Identity: 385/1460 - (26%)
• Similarity: 593/1460 - (40%)
• Gaps: 401/1460 - (27%)

  Fly    16 NATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLND------LYTRY 74
            |.:.|..|:.:.:...|...:|...:.:.:.|.|..:|.......|    ||::      |:.|.
Zfish    29 NDSHNQQVRPNQSVDHPDMSSSKPCKYSISSSCSSGELGVPRAVMT----HLSNPRRVPPLFERS 89

  Fly    75 RQRLRKSLFRSGLLTSLLAC--------------------VVSIIIGIVYG---------QHLVQ 110
            ..:.....|.|.:|..  ||                    ..:::.||.:|         ..||.
Zfish    90 AAQCWDPKFDSSILEE--ACRERCFPQMQRRFRYILFYLATAALLWGIYFGINSSRCEPTNFLVP 152

  Fly   111 TMLLVLAALI----------------SGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITG 159
            |...::..|:                :..:||.:.|...|:.......||...:.        ..
Zfish   153 TAGFLILCLVLLWFTFTKPYSRYYNHTSFLLTVIMFGITLAPQTQTAHFAHYDSH--------RA 209

  Fly   160 DELAPLPMY----------------ALFLCIHSMLPISWPVSVVLALFMTA-------IHIVY-- 199
            |..:|||:|                .:.|.::|:|.:....||:|.|..:.       :|:..
Zfish   210 DNQSPLPVYQNASCISPVGTFSLCMEVLLLLYSVLHLPLYASVLLGLLYSVLYEALGWLHLAQLD 274

  Fly   200 --RIGTSPDYAPNLPMLF-GEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECERE 261
              .:|:....:..|..|. |:.::...|.|.|::..|||:.....|.......|.....||.|:.
Zfish   275 ESYVGSREGISGTLSWLGPGKFLLHLCAHVVGIHIFIMSEVRSRSTFLKVGQAIMHGKDLEVEKA 339

  Fly   262 QQEQLLLSVIPAYIAAEVKRSIMLKMAD-------------ACQRAGGQASTSATR--------- 304
            .:|:::.||:|..:|.|     ::|..|             .|..|...|.||::.
Zfish   340 LKERMIHSVMPRSVADE-----LMKQGDEESESSGKRYSAGTCSVAAAAAVTSSSPKSHKRKKNS 399

  Fly   305 -------FHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIK 362
                   |...:::|...|:|||||||.||.:|::.:|..||..|||||||||::.:...|.:|.
Zfish   400 IPRGQIIFRPFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTSCEKIS 464

  Fly   363 ILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRK 427
            .||||||||:|.|.....||..||.|||.||.||....:.....|:||:|:|||.||||:||:::
Zfish   465 TLGDCYYCVAGCPEPLTDHAYCCVEMGLGMIQAIEQFCQEMSETVNMRVGVHTGTVLCGILGMKR 529

  Fly   428 WQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKV------- 485
            ::|||||:||.|||.||..||||:||:::.|..||.|::|.|.|....|    ..|.|
Zfish   530 FKFDVWSNDVNLANLMEQLGVAGKVHLSEVTAGFLDDRYEREDGRVIER----VGHSVTDQLKGL 590

  Fly   486 ESYLIVPPKPAYTYSVPRV---VECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPP 547
            ::|||...|........::   .|..|...||..|.      ..|.:|.|           :|.|
Zfish   591 KTYLISGRKLGSQCGCSQLSLGQEFGETLSPSSNTH------TPDHTHCA-----------IAEP 638

  Fly   548 PAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEP 612
            .:.......|.||:....                   :....||||          |:|..| |.
Zfish   639 QSHGKAGFMPCSISIDVV-------------------DNPTTDEAT----------QNGCQD-EH 673

  Fly   613 KANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAG 677
            :||.....:|.|..    |.:..||...::.:.:|             |||....:.....:.||
Zfish   674 RANSSKFPAGRSPK----ALNGLLSPLCEERVGVS-------------QSSLCDKLQEKDRSWAG 721

  Fly   678 GAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPS 742
            ..|      ||..:.|    ::..|.|...|.:|...|:|
Zfish   722 SLA------AEGKDHS----AILPLRSKNFREKSDAHFVE------------------------- 751

  Fly   743 SKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMW 807
                             .|.|..|:|:.                       ||.||  :...::.
Zfish   752 -----------------VIKEDSLMKDY-----------------------FFKPP--INKLSLN 774

  Fly   808 YRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLAL----FL 868
            :.....|:.||    |.:...:       ::...||.....:..:||..||:..|.|||    ||
Zfish   775 FLEKSLESAYR----TSYHEQV-------MNHVPVQTFASPVFSSLLDVLLSCTVFLALTMACFL 828

  Fly   869 Y-LSNMSVPDVHASTTERNGPGQVVASSRYLRL--AMFVVVNILISSCAVF-------------S 917
            | |.:|..|               :|::..|.:  |:..:|::|:|...:|             .
Zfish   829 YPLVSMQTP---------------LAATLGLAITAALLELVSLLLSIRMIFCLDDVQNCSRILLK 878

  Fly   918 VINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLW-EIDYA--IPIAPVFLYCCAISLAA 979
            :::..||..|              ..:|.|  :|..|.:: .:.|:  :||......|||:.:|.
Zfish   879 LVSGWVPRHV--------------IGAVLV--SLPAVSVFSHLAYSLQLPIQVTMFLCCALIIAI 927

  Fly   980 I--------SAFLRSGFI----LKLIAMLVAV-------------------IAQVTVLGYSDLFE 1013
            |        |.::||...    |.|:.:|.:.                   .|||.:||.|
Zfish   928 IQYCTFCQLSFWMRSALATVVGLSLLILLYSASIRTSATDAFPGFGNMSNQSAQVDLLGES---- 988

  Fly  1014 MYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKI 1078
              |.|.....| |.::..|...:::|::..|:|:.|...|..:....:....:.:::|||.....
Zfish   989 --NSAPTALDL-LVLETVLSFFLLLLLVWFLNREFEVSYRLHYHGNVEADKHRIKIQTMRDQADW 1050

  Fly  1079 LLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEII 1143
            ||.||:|.|||...    :..:.|.:::..|.|:||||.|:.|||:|:  .:.|.||.|:|||:|
Zfish  1051 LLRNIIPIHVAEQL----KVNQSYSKNHDNVGVIFASIVNFSEFYEES--YEGGKECYRVLNELI 1109

  Fly  1144 CDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTEEHNVVILVEFAIAL 1208
            .|||:||.:|.||.:||||||.:|||.||||. |::        ..|:.....::..|.:||:.:
Zfish  1110 GDFDELLRQPAFSNVEKIKTIGATYMAASGLN-GQQ--------CQEQPHPHAHLCALFDFALEM 1165

  Fly  1209 MSILDSINRESFQ-RFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTE 1272
            |.::|..|:.... :|:||||.||||:.|||||..|..||||.:|||:||||||.||..|:|.:|
Zfish  1166 MRVVDDFNKNMLGFKFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSE 1230

  Fly  1273 NTAKILMTAGYECECRGLTYVKGKGNLVTY 1302
            .:..:|....|..:.||...|||||.:.||
Zfish  1231 ESHCVLSRMNYAFDYRGTVNVKGKGQMRTY 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AcyC	72..470	CDD:441717	144/499 (29%)
		Guanylate_cyc	310..469	CDD:425528	83/158 (53%)
		Guanylate_cyc	1101..1305	CDD:425528	93/203 (46%)
adcy9	XP_003201145.3	None