DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gucy2g

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_009305067.2	Gene:	gucy2g / 100333350	ZFINID:	ZDB-GENE-130531-70	Length:	1127	Species:	Danio rerio

Alignment Length:	430	Identity:	105/430 - (24%)
Similarity:	178/430 - (41%)	Gaps:	127/430 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 PL-PMYALFLCIHSMLPI---SWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASA 224
            || |..:..:|...::|:   .|                   ..:||:.|.    ||.|
Zfish   771 PLRPTLSADICDERLIPLIKACW-------------------SENPDHRPP----FGSI------ 806

  Fly   225 SVSGLYYRIMSDA---AHNRTVDG-----------TRTGIEQRV-KLECEREQQEQLLLSVIPAY 274
                  .|.:.||   :|...:|.           ....:|:|. :|..|:.:.::||.|::|.|
Zfish   807 ------RRQLRDACPESHANILDNMVNKLEKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRY 865

  Fly   275 IAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLV 339
            ||.::       ||         ..:...|.:|:       |||.|:|||.||.:.|..:|.::|
Zfish   866 IADQL-------MA---------GKSVEPRSYEM-------VTIFFSDIVGFTTMCSVSSALEVV 907

  Fly   340 KTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISR-PQHATNCVNMGLQMIDAIRH--VRE 401
            ..||||:..||.|.:.....:::.:||.|...||||||. ..||.....|.|..:.:|:.  :|.
Zfish   908 TLLNDLYSLFDDIIKLYDVYKVETIGDAYMVASGLPISNGTLHAEEISTMALHFLSSIKRFKIRH 972

  Fly   402 ATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFL---G 463
            .....:.:||||::|.|:.||:|....::.::.|.|..|:.|||..:..::||::.|.|.|   |
Zfish   973 LPNERLALRIGINSGPVVAGVVGSTMPRYCLFGDTVNTASRMESNSLPLKIHISQSTADILLTIG 1037

  Fly   464 DKFEVEQ-------GEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTT---- 517
             .||:|:       |:|..:..:|..           ||.:|:....     :.::|||.:
Zfish  1038 -TFELEERGDIEIKGKGTQKTFWLLS-----------KPGFTFPPTG-----QDSNPSPKSGTDS 1085

  Fly   518 ----------------EETKEIKETDQSHEATDVADVLLP 541
                            :|.:.|:.|....:.||:..:.:|
Zfish  1086 CHIKQEKTKAANDGDFKERRTIQRTSAMTKMTDMYTLTVP 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	29/143 (20%)
		CYCc	259..467	CDD:214485	67/213 (31%)
		Guanylate_cyc	311..469	CDD:278633	57/163 (35%)
		BASP1	510..667	CDD:283191	9/52 (17%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gucy2g	XP_009305067.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810