DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gucy1a2

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	501	Identity:	122/501 - (24%)
Similarity:	190/501 - (37%)	Gaps:	147/501 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYT------RYRQ 76
            |||    .||..:...:.:||.:..:.:..|.|:.|             :.:::|      |.||
Zfish   136 TAN----EDGELSADSSPSSSPSPPSSSAPACLSFL-------------IREVHTPPTSSSRSRQ 183

  Fly    77 RLRKSL-FRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQFPAVL-----S 135
            ..|..| .|.||.|...|          :..|||           .||.:..||....|     :
Zfish   184 LSRSPLDLRIGLSTFCRA----------FPFHLV-----------LGSNMEVLQVGEGLRKQAKT 227

  Fly   136 SPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYR 200
            .|...|.|:  .:|.|                      :...:|.|:. :::|.| .|...|..|
Zfish   228 DPHRTLTFS--NSFEL----------------------VSPRIPCSFQ-NILLRL-STPFTIRTR 266

  Fly   201 -IGTSPDYAPNLPMLFGE---------IVMLASASVSGLYYRIMSDAAHNRTV---DGTR----- 247
             .|:|.|....:..|.|:         |:.|.|..|..| ..:|....|...:   |.||
Zfish   267 PDGSSLDCREKVMELKGQMLHLPESNSIMFLGSPRVDRL-EELMGRGLHLSDIPIHDATRDVILV 330

  Fly   248 -------TGIEQRV------------KLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQR 293
                   .|:::|:            .||.|:.:...||.|:.|               .|..||
Zfish   331 GEQAKAQDGLKKRMDKLKATLEKTHQALEEEKRRTVDLLYSIFP---------------GDVAQR 380

  Fly   294 AGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC 358
            ........|.:|.:        ||:||:|||.||.:.:..|...::..||:|:.|||.     ||
Zfish   381 LWQGLPVQAKKFDD--------VTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDY-----QC 432

  Fly   359 -----LRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNV 418
                 .:|:.:||.|....||......||.....|.|:|::....|....|..:.:|||||:|:|
Zfish   433 GILDVYKIETIGDAYCVAGGLHRKIDSHAKPIALMALKMMELSEEVLTPDGKPIKLRIGIHSGSV 497

  Fly   419 LCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGD 464
            |.||:|:...::.::.::||||:..|||.....::::..|...|.|
Zfish   498 LAGVVGVMMPRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLLRD 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	55/270 (20%)
		CYCc	259..467	CDD:214485	62/211 (29%)
		Guanylate_cyc	311..469	CDD:278633	52/159 (33%)
		BASP1	510..667	CDD:283191
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810