DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac76E and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001238874.1	Gene:	gucy1b1 / 100150304	ZFINID:	ZDB-GENE-090313-160	Length:	608	Species:	Danio rerio

Alignment Length:	350	Identity:	86/350 - (24%)
Similarity:	141/350 - (40%)	Gaps:	117/350 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 IVMLASASV--------SGLYYRIMSD-AAHNRTVDGTRTGIEQRVK------------------ 255
            |:.|.|.||        .|||   :|| ..|:.|.|....|.:.|.:
Zfish   319 ILFLCSPSVMNLDDLTRRGLY---LSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQHTL 380

  Fly   256 --LECEREQQEQLLLSVIPAYIAAEV--KRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNV 316
              ||.|:::.::||.||:|..:|.|:  ||.:..|                         |:.||
Zfish   381 RALEDEKKKTDRLLYSVLPPSVANELRHKRPVPAK-------------------------RYDNV 420

  Fly   317 TILFADIVNFTPLSSSLTASD----LVKTLNDLFGRFDQIAQENQ---CLRIKILGDCYYCVSGL 374
            ||||:.||.|....|...:::    :|..|||::.|||.:....:   ..:::.:||.|..||||
Zfish   421 TILFSGIVGFNAFCSKHASAEGAIKIVNLLNDIYTRFDILTDSRKNPYVYKVETVGDKYMTVSGL 485

  Fly   375 PISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTL 439
            |.....||.:..::.|.|::....|: .....|.:.||||||.|:.||:|.|..::.::.:.|.|
Zfish   486 PEPCTHHAKSICHLALDMMEIAGQVK-VDEDPVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNL 549

  Fly   440 ANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRV 504
            .:..|:.|..|::::::                                        |||   |.
Zfish   550 TSRTETTGEKGKINVSE----------------------------------------YTY---RC 571

  Fly   505 VECIEQNDP-------SPTTEETKE 522
            ::.:|..||       .|.|.:.|:
Zfish   572 LQSVENADPQFHLEYRGPVTMKGKK 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	28/101 (28%)
		CYCc	259..467	CDD:214485	59/216 (27%)
		Guanylate_cyc	311..469	CDD:278633	48/164 (29%)
		BASP1	510..667	CDD:283191	5/19 (26%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
gucy1b1	NP_001238874.1	HNOB	2..166	CDD:285002
		HNOBA	207..406	CDD:285003	24/89 (27%)
		CYCc	385..584	CDD:214485	66/267 (25%)
		Guanylate_cyc	412..605	CDD:278633	59/253 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810