DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac76E and adcy8

DIOPT Version :9

Sequence 1:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1284	Identity:	400/1284 - (31%)
Similarity:	599/1284 - (46%)	Gaps:	324/1284 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LNDLYTRY--RQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHL---------VQTMLL------ 114
            |..||.||  .|| |||:    ::.::|..|..:.:.::   ||         ::.|||
Zfish   140 LERLYQRYFLGQR-RKSV----VVMNILDVVTKLTLLVL---HLTLASTPMDPIKGMLLGFFTGI 196

  Fly   115 --VLAALI----SGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALF-- 171
              |:.||:    ..|....||:...::  ..|:|..|:.|   |....:.||.:.    |.||
Zfish   197 EVVICALVVVRKDTSSHGYLQYSGAVT--WVAMATQILAT---GLGYGLLGDGIG----YVLFTL 252

  Fly   172 LCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSD 236
            ...:||||:....::|..|..:|:||..::...|....:...|..::::....:.:|::...:||
Zfish   253 FATYSMLPLPLTWAIVAGLLTSALHIALQLLVPPRAQISTNQLLAQVLLFLCINTAGMFISYLSD 317

  Fly   237 AAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTS 301
            .|..:....||..||.|::||.|.::||:|:|||:|.::..|:... |..:.|         .|.
Zfish   318 RAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMIND-MTNVED---------ETL 372

  Fly   302 ATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGD 366
            ..:||.:::.|:.||:|||||:..||.||::|:|.:||:.||:||.|||::|.|:.|||||||||
Zfish   373 QHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGD 437

  Fly   367 CYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFD 431
            |||||||||..||.||..||.|||.||..||:||..|..::|||||||:|:||||||||||||||
Zfish   438 CYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFD 502

  Fly   432 VWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPA 496
            |||.||.:||.:||||:.||:||:|..||.|...:|||:|.|.:|:.:|..|.:|::||..|:.:
Zfish   503 VWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDFLRRHNIETFLIKQPEES 567

  Fly   497 YTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSIN 561
            ..                 |..|......|:||                      |.:.|.||..
Zfish   568 LL-----------------TLPEDIMRDSTNQS----------------------DHRTSNTSFT 593

  Fly   562 ----SQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSG 622
                |.|.|.|..:....::
Zfish   594 EGTWSPELPFHNIVGKQNTL--------------------------------------------- 613

  Fly   623 DSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVA 687
                       |||:..:.:||                    |..:.......||....|:
Zfish   614 -----------AALTRHSINLL--------------------PNHLAQALHVRAGSQEINA---- 643

  Fly   688 EAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECW 752
                                |.:|:        :::.||:..|..  |::
Zfish   644 --------------------RMQST--------IALRSGDKLRQE--HIS--------------- 663

  Fly   753 GADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMY 817
                                                              ||::.:|....|..|
Zfish   664 --------------------------------------------------PFSLTFREALLEHKY 678

  Fly   818 RAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHAST 882
            ....|..|:.:|:|||::...:..:|.:   |..|.:.::|..| |:.:.|:...:.|     :|
Zfish   679 SQMRDEVFKSNLVCAFIVLFFITGIQSL---LPSARMVTMLIQF-SVLILLHCCLVVV-----TT 734

  Fly   883 TERNGPGQVV-------ASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILES 940
            .|......:|       .:..|....:.:.::|||:..|  ::||....|........|||...|
Zfish   735 AEDYKCLPLVLRKACCWVNETYAARNVVIFLSILINFLA--AMINILWCDFDKSGSFRNQTFNAS 797

  Fly   941 NFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKL--IAMLVAVIAQV 1003
                    :::.|:..:. :|       |::...:::...:.|||...:|||  :.:::|:.|.:
Zfish   798 --------ASIPDICFYP-EY-------FVFTGVLAMVTCAVFLRLNSVLKLAILLIMIAIYAVL 846

  Fly  1004 TVLGYSDLFEMYNDANITHG---LPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVE 1065
            |...|:.||..|:...:...   |..:....||:.:.:|.:....:|.||.||.||||:.:.|.|
Zfish   847 TEAFYTPLFIRYDTLTLNQSKSFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEE 911

  Fly  1066 QEEVETMRGINKILLENILPAHVATHFLHLER-STELYHESYSCVAVMFASIPNYKEFYDETDVN 1129
            ..|:..:|..|:.:|.||||:|||.|||..:| :.|||.:||..|.|||||||.:.:||.:|::|
Zfish   912 INEMRELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMN 976

  Fly  1130 KQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATSRSFADEKRTE 1194
            .||:||||||||||.|||:||.:.:|..|||||||.||||..|||.|.|:.       .::|
Zfish   977 NQGVECLRLLNEIIADFDELLGEERFQDIEKIKTIGSTYMAVSGLSPEKQQ-------CEDK--- 1031

  Fly  1195 EHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRM 1259
            ..::..|.:|||||...:..||:.||..|:||||:.||.|:||||||:|||||||..|||:||||
Zfish  1032 WGHLCALADFAIALNESIQEINKHSFNNFQLRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLASRM 1096

  Fly  1260 DSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKG----KGNLVTYFV 1304
            ||.||.|::|..|.|..||...|:..|.||..||||    :|.:.|:|:
Zfish  1097 DSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGISEQEGKIRTHFM 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	65/246 (26%)
		CYCc	259..467	CDD:214485	114/207 (55%)
		Guanylate_cyc	311..469	CDD:278633	101/157 (64%)
		BASP1	510..667	CDD:283191	19/160 (12%)
		CYCc	1079..1283	CDD:214485	112/204 (55%)
		Guanylate_cyc	1101..1305	CDD:278633	110/208 (53%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	67/260 (26%)
		CYCc	340..538	CDD:214485	114/207 (55%)
		Guanylate_cyc	379..563	CDD:278633	111/183 (61%)
		DUF1053	592..685	CDD:283888	25/267 (9%)
		CYCc	919..1123	CDD:214485	115/213 (54%)
		Guanylate_cyc	948..1147	CDD:278633	110/208 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810