DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGDI and arhgdig

DIOPT Version :9

Sequence 1:	NP_001262080.1	Gene:	RhoGDI / 40179	FlyBaseID:	FBgn0036921	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_957451.1	Gene:	arhgdig / 394132	ZFINID:	ZDB-GENE-040426-1493	Length:	204	Species:	Danio rerio

Alignment Length:	200	Identity:	93/200 - (46%)
Similarity:	129/200 - (64%)	Gaps:	4/200 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAETETKHHPEHHDDDVHDANYQAPPEKTIEEIMAADQEDESLRRYKEALLGAAQTEKIIVEPND 65
            ||:.| |..|...|:|..|.|||.|.:|:::||...|::||||.:||:.|||:.   .::.:|..
Zfish     1 MADKE-KDVPVVEDEDEPDLNYQPPAQKSLQEIQEMDKDDESLTKYKQTLLGSG---PVVADPTI 61

  Fly    66 PRKVIVKKLALVVEGRDDMELDLTGDLSQLKKQLFVIKEGVQYKVRIDFIVQREIVHGLKYVQKT 130
            |...:.:...:..:....:.:||||||:.|||:.|.:||||:|:|:|.|.|.|:||.|||||.:|
Zfish    62 PNVQVTRLTLMCDQAPGPITMDLTGDLNALKKKCFTMKEGVEYRVKIHFKVNRDIVSGLKYVHQT 126

  Fly   131 SRLGVNVDKMKHMVGSYPPKKEIQFYLTPAEEAPSGTFSRGTYSVSSVFTDDDKHIHLEWDWTFE 195
            .:.|:.:||..:|||||.|:.|...::||.||||.|...||||.:.|.||||||..||.|||...
Zfish   127 YKKGLRLDKAVYMVGSYGPRAEEHEFMTPVEEAPKGMIVRGTYHIKSFFTDDDKTDHLSWDWNLL 191

  Fly   196 IKKDW 200
            |||||
Zfish   192 IKKDW 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGDI	NP_001262080.1	Rho_GDI	14..199	CDD:280310	85/184 (46%)
arhgdig	NP_957451.1	Rho_GDI	13..195	CDD:280310	85/184 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580573
Domainoid	1	1.000	191	1.000	Domainoid score	I3183
eggNOG	1	0.900	-	-		E1_KOG3205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3792
OMA	1	1.010	-	-		QHG54245
OrthoDB	1	1.010	-	-		D1265661at2759
OrthoFinder	1	1.000	-	-		FOG0001289
OrthoInspector	1	1.000	-	-		otm26523
orthoMCL	1	0.900	-	-		OOG6_102354
Panther	1	1.100	-	-	LDO	PTHR10980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2126
SonicParanoid	1	1.000	-	-		X792
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800