DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGDI and Arhgdia

DIOPT Version :9

Sequence 1:	NP_001262080.1	Gene:	RhoGDI / 40179	FlyBaseID:	FBgn0036921	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001350354.1	Gene:	Arhgdia / 192662	MGIID:	2178103	Length:	204	Species:	Mus musculus

Alignment Length:	189	Identity:	99/189 - (52%)
Similarity:	130/189 - (68%)	Gaps:	5/189 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HDDDVHDANYQAPPEKTIEEIMAADQEDESLRRYKEALLGAAQTEKIIVEPNDPRKVIVKKLALV 77
            :::|.|..||:.|.:|:|:||...|::|||||:|||||||..   .:..:||.| .|||.:|.||
Mouse    18 NEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRV---AVSADPNVP-NVIVTRLTLV 78

  Fly    78 VE-GRDDMELDLTGDLSQLKKQLFVIKEGVQYKVRIDFIVQREIVHGLKYVQKTSRLGVNVDKMK 141
            .. ....:||||||||...|||.||:||||:|:::|.|.|.||||.|:||:|.|.|.||.:||..
Mouse    79 CSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTD 143

  Fly   142 HMVGSYPPKKEIQFYLTPAEEAPSGTFSRGTYSVSSVFTDDDKHIHLEWDWTFEIKKDW 200
            :|||||.|:.|...:|||.||||.|..:||:|::.|.||||||..||.|:|...|||:|
Mouse   144 YMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEW 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGDI	NP_001262080.1	Rho_GDI	14..199	CDD:280310	97/185 (52%)
Arhgdia	NP_001350354.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		6/17 (35%)
Arhgdia	NP_001350354.1	Rho_GDI	11..201	CDD:396612	97/186 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837036
Domainoid	1	1.000	195	1.000	Domainoid score	I3138
eggNOG	1	0.900	-	-		E1_KOG3205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H908
Inparanoid	1	1.050	199	1.000	Inparanoid score	I3780
Isobase	1	0.950	-	0	Normalized mean entropy	S950
OMA	1	1.010	-	-		QHG54245
OrthoDB	1	1.010	-	-		D1265661at2759
OrthoFinder	1	1.000	-	-		FOG0001289
OrthoInspector	1	1.000	-	-		otm42349
orthoMCL	1	0.900	-	-		OOG6_102354
Panther	1	1.100	-	-	O	PTHR10980
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2126
SonicParanoid	1	1.000	-	-		X792
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750