DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8004 and MTX1

DIOPT Version :9

Sequence 1:	NP_649161.1	Gene:	CG8004 / 40178	FlyBaseID:	FBgn0036920	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_002446.3	Gene:	MTX1 / 4580	HGNCID:	7504	Length:	466	Species:	Homo sapiens

Alignment Length:	230	Identity:	60/230 - (26%)
Similarity:	97/230 - (42%)	Gaps:	22/230 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LAVKAYLKMCNLPFLIRSCANAEHMSPGGRMTKLPFIRA--GAFIFAEFEPIVNFVEQKELAIGS 106
            |||..|.:....|..:...:| ...||.|   .||.:|.  |..|....:.|.:..::|..|
Human   173 LAVLTYARFTGAPLKVHKISN-PWQSPSG---TLPALRTSHGEVISVPHKIITHLRKEKYNA--- 230

  Fly   107 WQDED----EKADMRTYVSLVENIFTMAELYISFKNERVYKEVTAPRNGVVFPWPLN-----HMQ 162
              |.|    :.||...::||:|.......::..:.:.:.|.|||........|:|||     .||
Human   231 --DYDLSARQGADTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQ 293

  Fly   163 NYGKRRNALRLLKVYQWDDLDIDSVIDKVAKCCETLEYKLKESPETPFFYGDQPCELDAIAFGHL 227
            .....|..|...:....|:.:::..:.:.|:.|.||..:...|.:  ||:||.|..|||..|.:|
Human   294 RQYMERLQLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQK--FFFGDAPASLDAFVFSYL 356

  Fly   228 FSILTTTLPNMALAQTVQKFQHLVEFCRFVDEKYF 262
            ..:|...||:..|...::...:|..:|..:...||
Human   357 ALLLQAKLPSGKLQVHLRGLHNLCAYCTHILSLYF 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8004	NP_649161.1	GST_N_Metaxin2	24..100	CDD:239377	15/57 (26%)
CG8004	NP_649161.1	GST_C_Metaxin2	130..258	CDD:198320	34/132 (26%)
MTX1	NP_002446.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133
		Tom37	156..293	CDD:313732	32/128 (25%)
		GST_C_Metaxin1_3	255..391	CDD:198321	34/137 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422112at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2657
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950