DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8004 and MTX3

DIOPT Version :9

Sequence 1:	NP_649161.1	Gene:	CG8004 / 40178	FlyBaseID:	FBgn0036920	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_001350747.1	Gene:	MTX3 / 345778	HGNCID:	24812	Length:	312	Species:	Homo sapiens

Alignment Length:	234	Identity:	59/234 - (25%)
Similarity:	99/234 - (42%)	Gaps:	14/234 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LPE-NASCLAVKAYLKMCNLPFLIRSCANAEHMSPGGRMTKLPFIRAGAFIFAEFEPIVNFVEQK 100
            ||. ::..|.|.||.|....|..:....|....|.|    .:|.:.....:.::...|:||:.::
Human    16 LPSVHSESLVVMAYAKFSGAPLKVNVIDNTWRGSRG----DVPILTTEDDMVSQPAKILNFLRKQ 76

  Fly   101 ELAIGSWQDEDEKADMRTYVSLVENIFTMAELYISFKNERVYKEVTAPRNGVVFPWPLNHMQNYG 165
            :..........:.||...|::|:|.....|.|:..:.....|..||.|......|:||:.:....
Human    77 KYNADYELSAKQGADTLAYIALLEEKLLPAVLHTFWVESDNYFTVTKPWFASQIPFPLSLILPGR 141

  Fly   166 KRRNAL-RLLKVYQWDDL----DIDSVIDKVAK-CCETLEYKLKESPETPFFYGDQPCELDAIAF 224
            ..:.|| |:|.......|    ::::.|.:.|| |...|..:|..|   .||:||.|..|||..|
Human   142 MSKGALNRILLTRGQPPLYHLREVEAQIYRDAKECLNLLSNRLGTS---QFFFGDTPSTLDAYVF 203

  Fly   225 GHLFSILTTTLPNMALAQTVQKFQHLVEFCRFVDEKYFQ 263
            |.|..:.....|.:.|.:.:::..:|..||..:...||:
Human   204 GFLAPLYKVRFPKVQLQEHLKQLSNLCRFCDDILSSYFR 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8004	NP_649161.1	GST_N_Metaxin2	24..100	CDD:239377	15/63 (24%)
CG8004	NP_649161.1	GST_C_Metaxin2	130..258	CDD:198320	37/133 (28%)
MTX3	NP_001350747.1	Tom37	23..142	CDD:371142	27/122 (22%)
		GST_C_Metaxin1_3	105..241	CDD:198321	37/138 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422112at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2657
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950