DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8004 and MTX2

DIOPT Version :9

Sequence 1:	NP_649161.1	Gene:	CG8004 / 40178	FlyBaseID:	FBgn0036920	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_006545.1	Gene:	MTX2 / 10651	HGNCID:	7506	Length:	263	Species:	Homo sapiens

Alignment Length:	261	Identity:	112/261 - (42%)
Similarity:	166/261 - (63%)	Gaps:	11/261 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 YLSQLITADKLSAEPWPEDATLYQPYEAEQILLPENASCLAVKAYLKMCNLPFLIRSCANAEHMS 69
            ::||:     .:||||||:|||||..:.|||||.:||:.|||:|:|:|||||..:...||||:||
Human     8 FVSQI-----AAAEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCRANAEYMS 67

  Fly    70 PGGRMTKLPFIRAGAFIFAEFEPIVNFVEQKELAIGSWQDEDEKADMRTYVSLVENIFTMAELYI 134
            |.|   |:|||..|..:.:|..|||.||:.|..::....:|.:||:|:.|:.||.|:...||||:
Human    68 PSG---KVPFIHVGNQVVSELGPIVQFVKAKGHSLSDGLEEVQKAEMKAYMELVNNMLLTAELYL 129

  Fly   135 SFKNERVYKEVTAPRNGVVFPWPLNHMQNYGKRRNALRLLKVYQWDDLDIDSVIDKVAKCCETLE 199
            .:.:|....|:|..|.|..:||||||:..|.|:....|.:|...|....:|.|::.|.:||:.|.
Human   130 QWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALS 194

  Fly   200 YKLKESPETPFFYGDQPCELDAIAFGHLFSILTTTLPNMALAQTVQKFQHLVEFCRFVDEKYFQT 264
            .:|...   |:|:..||.||||:.||||::||||.|.|..|::.|:.:.:|:.|||.:::.||:.
Human   195 QRLGTQ---PYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYFED 256

  Fly   265 R 265
            |
Human   257 R 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8004	NP_649161.1	GST_N_Metaxin2	24..100	CDD:239377	41/75 (55%)
CG8004	NP_649161.1	GST_C_Metaxin2	130..258	CDD:198320	51/127 (40%)
MTX2	NP_006545.1	GST_N_Metaxin2	22..95	CDD:239377	41/75 (55%)
MTX2	NP_006545.1	GST_C_Metaxin2	125..250	CDD:198320	51/127 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159099
Domainoid	1	1.000	108	1.000	Domainoid score	I6434
eggNOG	1	0.900	-	-		E1_KOG3027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4777
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3529
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52965
OrthoDB	1	1.010	-	-		D1219712at2759
OrthoFinder	1	1.000	-	-		FOG0005469
OrthoInspector	1	1.000	-	-		otm40588
orthoMCL	1	0.900	-	-		OOG6_105112
Panther	1	1.100	-	-	LDO	PTHR12289
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2657
SonicParanoid	1	1.000	-	-		X3890
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800