DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grasp65 and GRH1

DIOPT Version :9

Sequence 1:	NP_649160.1	Gene:	Grasp65 / 40177	FlyBaseID:	FBgn0036919	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_010805.1	Gene:	GRH1 / 852129	SGDID:	S000002925	Length:	372	Species:	Saccharomyces cerevisiae

Alignment Length:	335	Identity:	80/335 - (23%)
Similarity:	129/335 - (38%)	Gaps:	104/335 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LEAFFDFIVAIAGTRLD----------QDNDMLKELLRQNVDKPVRLTVYSSKTQTVRELTLT-- 85
            |::|||:||......:.          .|...:..:..::..:.:::.::|:|..|.|:..::
Yeast    80 LQSFFDYIVGFNDDPVPVVSNQHGFSYPDYRRITSIFNEHCGRTLKVNIWSAKGGTFRDEYISII 144

  Fly    86 ------------------PSNNWGGQ-GLLGVSIRFCSFEGANESVWHILEVH-PNSPAELAGLR 130
                              ||:....| ..||..:::.... |:...:|||.|: |:.||:.|||.
Yeast   145 SKESDDLDDVSLNHDERRPSSGEAHQFQALGFKVQWTPLI-ASTFTYHILNVNIPDGPAQSAGLI 208

  Fly   131 AYSDYVIGA-DAIRHENDD--LFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGC 192
            ...||:||. |.:.....:  |..::.:.....|.:||||...|..|.:|:.    .|.:|.|||
Yeast   209 PDEDYIIGCQDGLLATGGETLLQDIVRSRANYDLVLYVYNKVSDCVRPITVH----IGPDGRLGC 269

  Fly   193 GIGFGYLHRIPV------QAE-------------PVTSSSAAVPAAAAAESTAPLLTAGGAAPAG 238
            .:|:|:|||||.      ||:             ||.|.:|.||:|..|
Yeast   270 NVGYGFLHRIPTVKHCPQQAQQQGQDDNPVPVPVPVESETAFVPSAFTA---------------- 318

  Fly   239 AQVAQVVSPTLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATD-ALTAALESQATI 302
                          ||:.....|.|.:...|.       ....|||  |..| :.|||..:::.|
Yeast   319 --------------PPVPTKKKSKNKKGTQPL-------AMDDYFN--EGRDKSSTAAKSAESDI 360

  Fly   303 AEPVSVPAPP 312
            ..|     ||
Yeast   361 LAP-----PP 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ	<14..100	CDD:294084	16/97 (16%)
Grasp65	NP_649160.1	GRASP55_65	69..205	CDD:282364	46/166 (28%)
GRH1	NP_010805.1	GRH1	1..372	CDD:227558	80/335 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346075
Domainoid	1	1.000	62	1.000	Domainoid score	I2499
eggNOG	1	0.900	-	-		E1_COG5233
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002082
OrthoInspector	1	1.000	-	-		oto98976
orthoMCL	1	0.900	-	-		OOG6_102404
Panther	1	1.100	-	-	LDO	PTHR12893
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1703
SonicParanoid	1	1.000	-	-		X1377
TreeFam	0	0.000	Not matched by this tool.
	11	10.770