DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grasp65 and Gorasp2

DIOPT Version :9

Sequence 1:	NP_649160.1	Gene:	Grasp65 / 40177	FlyBaseID:	FBgn0036919	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_081628.3	Gene:	Gorasp2 / 70231	MGIID:	2135962	Length:	451	Species:	Mus musculus

Alignment Length:	492	Identity:	204/492 - (41%)
Similarity:	268/492 - (54%)	Gaps:	87/492 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSSHSIHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDK 65
            ||||.|:.:|||||||||||:||:||||.:||||.||||||:|.|:||::|||.||:||:.||:|
Mouse     1 MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEK 65

  Fly    66 PVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLR 130
            ||::.:|||||..:||.::||||.||||||||||||||||:||||:|||:|||..||||.|||||
Mouse    66 PVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLR 130

  Fly   131 AYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIG 195
            .:|||:||||.:.:|::|||:||||||.:|||:||||.|.|.||||.|.||:||||||:||||||
Mouse   131 PHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIG 195

  Fly   196 FGYLHRIP------------------------------VQAEPVTSSSAAVPAAAAAESTAPLLT 230
            :|||||||                              ||...|:..|.:.|.....|.:...|:
Mouse   196 YGYLHRIPTRPFEEGKKISLPGQMTGTPITPLKDGFTEVQLSSVSPPSLSPPGTTGVEQSLSGLS 260

  Fly   231 AGGAAPAGAQVAQVVSPTLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAA 295
            ...|.||.:.|.....||:|.:||..|...::...:.|.|..|   ||.           .|:|.
Mouse   261 ISSAPPAVSNVLSTGVPTVPLLPPQVNQSLASMPPMNPATTLP---SLM-----------PLSAG 311

  Fly   296 LESQATI--AEPVSVPAPPAVADVSVAQPQVQVPA-PAQPLPPPANIFIPGVFDPSTQQNANALG 357
            |.|...:  ....::|||..:..|.:  |::..|. |..|..||.|  :||:
Mouse   312 LPSLPNLPSLSNFNLPAPHIMPGVGL--PELGSPGLPPLPSLPPRN--LPGI------------- 359

  Fly   358 GIPAAQLPFPQATAAPAAVPMFSAPQQAYMSAPAALSYPAGAQTVPSYPQVQPSMGGLFPTQPTP 422
                            |.:||.|....::...|...|..:..:.:.|.|.:.|....:..|....
Mouse   360 ----------------APLPMLSDFLPSFPLVPEGSSAASAGEPLSSLPAMGPPSDPVMTTAKAD 408

  Fly   423 LPPQMAHVFAPPVPPQAGAAPAAGNDELSG--PAVNQ 457
            .......|.:|     |...|....|.:|.  |||.:
Mouse   409 ASSLTVDVTSP-----ASKVPTTVEDRVSDCTPAVEK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ	<14..100	CDD:294084	59/85 (69%)
Grasp65	NP_649160.1	GRASP55_65	69..205	CDD:282364	98/165 (59%)
Gorasp2	NP_081628.3	PDZ	<14..100	CDD:294084	59/85 (69%)
		GRASP. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01214	15..215		136/199 (68%)
		GRASP55_65	69..205	CDD:282364	98/135 (73%)
		Important for membrane binding. /evidence=ECO:0000250	194..199		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..255		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..451		14/69 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849169
Domainoid	1	1.000	220	1.000	Domainoid score	I2615
eggNOG	1	0.900	-	-		E1_COG5233
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2300
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002082
OrthoInspector	1	1.000	-	-		oto91974
orthoMCL	1	0.900	-	-		OOG6_102404
Panther	1	1.100	-	-	O	PTHR12893
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.750