DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grasp65 and Gorasp1

DIOPT Version :9

Sequence 1:	NP_649160.1	Gene:	Grasp65 / 40177	FlyBaseID:	FBgn0036919	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_062258.2	Gene:	Gorasp1 / 56082	RGDID:	621122	Length:	446	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	176/471 - (37%)
Similarity:	244/471 - (51%)	Gaps:	90/471 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSSHSIHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDK 65
            ||...|...|.|| ||:|:..||:|||.|:||||.:||||:.|..:||:::||.||.||:.||:|
  Rat     1 MGLGASSEQPAGG-EGFHLHGVQENSPAQQAGLEPYFDFIITIGHSRLNKENDTLKALLKANVEK 64

  Fly    66 PVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLR 130
            ||:|.|::.||..|||:.:.|||.||||||||.|:|||||..|:|.|||:|:|.|:|||.|||||
  Rat    65 PVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASVRFCSFRRASEHVWHVLDVEPSSPAALAGLR 129

  Fly   131 AYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIG 195
            .|:||::|:|.|..|::|.|||||:||.:|||:.|||.:.|:|||||:.||.||||||:||||||
  Rat   130 PYTDYIVGSDQILQESEDFFTLIESHEGKPLKLMVYNSESDSCREVTVTPNAAWGGEGSLGCGIG 194

  Fly   196 FGYLHRIPVQ-----AEPVTSSSAAVPAAAAAESTAPLLTAGGAAP--------AGAQVAQVVSP 247
            :|||||||.|     .:|.::||...||.....:..||    ||.|        :|.::....|.
  Rat   195 YGYLHRIPTQPSSQYKKPPSASSPGTPAKTPQPNAFPL----GAPPPWPIPQDSSGPELGSRQSD 255

  Fly   248 TLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAALESQATIAEPVSVPAPP 312
            .:..:|.:...|                                    :|.|        :|.|.
  Rat   256 YMEALPQVPGGF------------------------------------MEEQ--------LPGPG 276

  Fly   313 A----VADVSVAQPQVQVPAPAQPLPPPANIFIPGVFDPS-----TQQNANALGGIPAAQLPFPQ 368
            :    .||.......:::  |.||.||...:..||..|.|     ...|.:....:.::.|..|.
  Rat   277 SPGHGTADYGGCLHSMEI--PLQPPPPVQRVMDPGFLDVSGMSLLDSSNTSVCPSLSSSSLLTPT 339

  Fly   369 ATAAPAAVPMFSAPQQAYMSAPAALSYPAGAQTVPSYPQVQPSMGGLFPTQPTPLPPQMAHVFAP 433
            |.:|       ..|:....|:.   |:..|.:...|..:.:.|    ||..|.. ..|:.|:  |
  Rat   340 AVSA-------LGPEDIGSSSS---SHERGGEATWSGSEFEIS----FPDSPGS-QAQVDHL--P 387

  Fly   434 PVPPQAGAAPAAGNDE 449
            .:....|...||..:|
  Rat   388 RLTLPDGLTSAASPEE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ	<14..100	CDD:294084	49/85 (58%)
Grasp65	NP_649160.1	GRASP55_65	69..205	CDD:282364	88/135 (65%)
Gorasp1	NP_062258.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		9/19 (47%)
		GRASP. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01214	14..214		121/199 (61%)
		PDZ	<14..99	CDD:294084	49/84 (58%)
		GRASP55_65	68..204	CDD:282364	88/135 (65%)
		Essential for interaction with GOLGA2/GM130	189..201		10/11 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..252		12/51 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5233
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366434at2759
OrthoFinder	1	1.000	-	-		FOG0002082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102404
Panther	1	1.100	-	-	LDO	PTHR12893
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1377
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710