DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grasp65 and gorasp1

DIOPT Version :9

Sequence 1:	NP_649160.1	Gene:	Grasp65 / 40177	FlyBaseID:	FBgn0036919	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001004805.1	Gene:	gorasp1 / 448042	XenbaseID:	XB-GENE-976361	Length:	417	Species:	Xenopus tropicalis

Alignment Length:	482	Identity:	184/482 - (38%)
Similarity:	252/482 - (52%)	Gaps:	111/482 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSSHSIHVP--GGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNV 63
            ||.|.|:...  .||||||||..:|:|||.|.||||.|||||:||...||:::|.|.|:||:.|.
Frog     1 MGLSMSLSSEPLEGGTEGYHVHGIQENSPAQSAGLEPFFDFIIAIGHARLNKENSMFKDLLKANA 65

  Fly    64 DKPVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAG 128
            :|||:|.||::|:..|||:.:||||.||||||||.|:|||||:||||.|||:|:|.|||||.|||
Frog    66 EKPVKLEVYNTKSMKVREVEVTPSNMWGGQGLLGASVRFCSFQGANEHVWHVLDVEPNSPAALAG 130

  Fly   129 LRAYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCG 193
            |::::||::|:|.|..|::|.:.|:|.||.:|||:.|||.:.|:||||.:.||:||||||:||||
Frog   131 LQSHTDYIVGSDQILQESEDFYALVEAHEGKPLKLLVYNTETDSCREVFVTPNSAWGGEGSLGCG 195

  Fly   194 IGFGYLHRIPVQ-AEPVTSSSAAVPAAAAAESTAPLLTAGGAAPAGAQVAQVVSPTLPYIPPLAN 257
            ||:|||||||:: |.|:.::          |.|.|                  ||..|...||.
Frog   196 IGYGYLHRIPLKPASPIKNT----------EITPP------------------SPLTPKEEPLV- 231

  Fly   258 TFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAALESQATIAEPVSVPAPPAVADVSVAQP 322
                           ||.....:|..   .|.|..|.|.|      |.:::|.         :..
Frog   232 ---------------PPTNGYRETAL---MAGDGQTDATE------EAINLPG---------STE 263

  Fly   323 QVQVPAPAQP---LPPPA-NIFIPGVFDPSTQQNANALGGIPAAQLPFPQAT-------AAPAAV 376
            |:.:..||:.   ||||. .:..|||.|||    |.::..||..:.....|:       |.||..
Frog   264 QMDLGNPAESSLVLPPPVQRVLHPGVLDPS----ALSMPEIPDIKQLIDMASPASMDLAAEPAGT 324

  Fly   377 PMFSAPQ--QAYMSAPAALSYPAGAQTVPSYPQVQPSMGGLFPTQPTPLP--------------- 424
            ..|...:  :|:| ...:.|..|....:.|:| .:.|:    |....|||
Frog   325 KQFIGAEELEAFM-GQVSFSEGAAVDNLASHP-AEDSL----PAPGNPLPPHWGLEEVTSEMTFE 383

  Fly   425 ----PQMAHVFAPP----VPPQAGAAP 443
                |.::...|||    .||:....|
Frog   384 NEQSPDVSDAAAPPEGDLTPPEQLVTP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ	<14..100	CDD:294084	52/85 (61%)
Grasp65	NP_649160.1	GRASP55_65	69..205	CDD:282364	86/135 (64%)
gorasp1	NP_001004805.1	PDZ	3..102	CDD:320768	56/98 (57%)
gorasp1	NP_001004805.1	GRASP55_65	71..205	CDD:309581	84/133 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2432
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366434at2759
OrthoFinder	1	1.000	-	-		FOG0002082
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010