DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grasp65 and GORASP2

DIOPT Version :9

Sequence 1:	NP_649160.1	Gene:	Grasp65 / 40177	FlyBaseID:	FBgn0036919	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_056345.3	Gene:	GORASP2 / 26003	HGNCID:	17500	Length:	452	Species:	Homo sapiens

Alignment Length:	484	Identity:	204/484 - (42%)
Similarity:	267/484 - (55%)	Gaps:	117/484 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSSHSIHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDK 65
            ||||.|:.:|||||||||||:||:||||.:||||.||||||:|.|:||::|||.||:||:.||:|
Human     1 MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEK 65

  Fly    66 PVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLR 130
            ||::.:|||||..:||.::||||.||||||||||||||||:||||:|||:|||..||||.|||||
Human    66 PVKMLIYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLR 130

  Fly   131 AYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIG 195
            .:|||:||||.:.:|::|||:||||||.:|||:||||.|.|.||||.|.||:||||||:||||||
Human   131 PHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIG 195

  Fly   196 FGYLHRIPVQAEPVTSSSAAVPAAAAAESTAPLLTAGGAAPAGAQVAQVVSPTLPYIPPLANTFG 260
            :|||||||.:           |.....:.:.|...||             :|    |.||.:.|.
Human   196 YGYLHRIPTR-----------PFEEGKKISLPGQMAG-------------TP----ITPLKDGFT 232

  Fly   261 STN-AEVRPPTIEPPAQSLFKTYFNPDEATDALTAALESQATIAEPVSVPA-PPAVADVSVAQPQ 323
            ... :.|.||::.||.                 |..:|...|   .:|:.: ||||:.|
Human   233 EVQLSSVNPPSLSPPG-----------------TTGIEQSLT---GLSISSTPPAVSSV------ 271

  Fly   324 VQVPAPAQPLPPPANIFIPGVFDPSTQQNANALGGIPAAQLPFPQATAAPAAVPMFSAPQQAYMS 388
            :....|..||.||              |...:|..:|    |...||..|..:|:
Human   272 LSTGVPTVPLLPP--------------QVNQSLTSVP----PMNPATTLPGLMPL---------- 308

  Fly   389 APAALSYPAGAQTVPSY------PQVQPSMG-------GLFP-----------TQPTPLPPQMAH 429
                   |||...:|:.      |.:.|.:|       ||.|           ..|.|||.:...
Human   309 -------PAGLPNLPNLNLNLPAPHIMPGVGLPELVNPGLPPLPSMPPRNLPGIAPLPLPSEFLP 366

  Fly   430 VFAPPVPPQAGAAPAAGNDELSGPAVNQA 458
            .|  |:.|::.:|.::|....|.|..:.|
Human   367 SF--PLVPESSSAASSGELLSSLPPTSNA 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ	<14..100	CDD:294084	59/85 (69%)
Grasp65	NP_649160.1	GRASP55_65	69..205	CDD:282364	98/135 (73%)
GORASP2	NP_056345.3	PDZ	<14..100	CDD:320768	59/85 (69%)
		GRASP. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01214	15..215		137/210 (65%)
		GRASP55_65	69..205	CDD:309581	98/135 (73%)
		Important for membrane binding	194..199		3/4 (75%)
		Atrophin-1	<241..397	CDD:331285	48/216 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..452		6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158790
Domainoid	1	1.000	220	1.000	Domainoid score	I2637
eggNOG	1	0.900	-	-		E1_COG5233
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2366
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1366434at2759
OrthoFinder	1	1.000	-	-		FOG0002082
OrthoInspector	1	1.000	-	-		oto88403
orthoMCL	1	0.900	-	-		OOG6_102404
Panther	1	1.100	-	-	O	PTHR12893
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1703
SonicParanoid	1	1.000	-	-		X1377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790