Protein Alignment Grasp65 and Gorasp2

DIOPT Version :10

• Sequence 1: NP_649160.1
• Gene: Grasp65 / 40177
• FlyBaseID: FBgn0036919
• Length: 460
• Species: Drosophila melanogaster
• Sequence 2: NP_001007721.1
• Gene: Gorasp2 / 113961
• RGDID: 619911
• Length: 454
• Species: Rattus norvegicus
• Alignment Length: 479
• Identity: 206/479 - (43%)
• Similarity: 267/479 - (55%)
• Gaps: 93/479 - (19%)

  Fly     1 MGSSHSIHVPGGGTEGYHVLKVQDNSPGQKAGLEAFFDFIVAIAGTRLDQDNDMLKELLRQNVDK 65
            ||||.|:.:|||||||||||:||:||||.:||||.||||||:|.|:||::|||.||:||:.||:|
  Rat     1 MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEK 65

  Fly    66 PVRLTVYSSKTQTVRELTLTPSNNWGGQGLLGVSIRFCSFEGANESVWHILEVHPNSPAELAGLR 130
            ||::.:|||||..:||.::||||.||||||||||||||||:||||:|||:|||..||||.|||||
  Rat    66 PVKMLIYSSKTLELREASVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLR 130

  Fly   131 AYSDYVIGADAIRHENDDLFTLIETHEQQPLKMYVYNLDDDACREVTIKPNTAWGGEGALGCGIG 195
            .:|||:||||.:.:|::|||:||||||.:|||:||||.|.|.||||.|.||:||||||:||||||
  Rat   131 PHSDYIIGADTVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIG 195

  Fly   196 FGYLHRIP------------------------------VQAEPVTSSSAAVPAAAAAESTAPLLT 230
            :|||||||                              ||...|:..|.:.|..|..|.:...|:
  Rat   196 YGYLHRIPTRPFEEGKKISLPGQMTGTPMTPPKDGFTEVQLSSVSPPSLSPPGTAGVEQSLSGLS 260

  Fly   231 AGGAAPAGAQVAQVVSPTLPYIPPLANTFGSTNAEVRPPTIEPPAQSLFKTYFNPDEATDALTAA 295
            ...|.||.:.|.....||:|.:||..|   .:.|.|.|..   ||.:|        .:...|:|.
  Rat   261 ISSAPPAVSNVLSTGVPTVPLLPPQVN---QSLASVPPMN---PAATL--------PSLMPLSAG 311

  Fly   296 LESQATI--AEPVSVPAPPAVADVSVAQPQVQVPA-PAQPLPPPANIFIPGVFDPSTQQNANALG 357
            |.|...:  ....::|||..:..|.:  |::..|. |..|..||.|  :||:
  Rat   312 LPSLPNLPSLSNFNLPAPHIMPGVGL--PELGKPGLPPLPSLPPRN--LPGI------------- 359

  Fly   358 GIPAAQLPFPQ------------ATAAPAAVPMFSAPQQAYMSAPAALSYPAG-----------A 399
                |.||.|.            ::||.|..|:.|.|.....|.|...:..|.           |
  Rat   360 ----APLPMPSDFLPSFPLVPEGSSAASAGEPLSSLPAMGPPSDPVMTTAKADTSSLTVDVMSPA 420

  Fly   400 QTVPSYPQVQPSMGGLFPTQPTPL 423
            ..||:  .|:..:....|....|:
  Rat   421 SKVPT--TVEDRVSDCTPAMEKPV 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Grasp65	NP_649160.1	PDZ_canonical	<14..100	CDD:483948	59/85 (69%)
		GRASP55_65	69..205	CDD:427981	98/165 (59%)
Gorasp2	NP_001007721.1	PDZ_canonical	<14..100	CDD:483948	59/85 (69%)
		GRASP. /evidence=ECO:0000255|PROSITE-ProRule:PRU01214	15..215		136/199 (68%)
		GRASP55_65	69..204	CDD:427981	97/134 (72%)
		Important for membrane binding. /evidence=ECO:0000250	194..199		3/4 (75%)
		PHA03247	<217..422	CDD:223021	55/239 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..454		15/68 (22%)