Protein Alignment Rpn1 and RPN1

DIOPT Version :10

• Sequence 1: NP_649158.1
• Gene: Rpn1 / 40174
• FlyBaseID: FBgn0028695
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_011892.1
• Gene: RPN1 / 856422
• SGDID: S000001069
• Length: 993
• Species: Saccharomyces cerevisiae
• Alignment Length: 1005
• Identity: 406/1005 - (40%)
• Similarity: 599/1005 - (59%)
• Gaps: 124/1005 - (12%)

  Fly    18 EGDAK----------DPKAKKDEKKDGKDKEQQPELSDEDQQLQEELELLVQHLQEPDAKLYQPT 72
            |.|.|          .|:.:...||| |.||::.:||:||.:|:.:|||||:.|:|.|:.||:.:
Yeast     4 ESDKKQQTIDEQSQISPEKQTPNKKD-KKKEEEEQLSEEDAKLKTDLELLVERLKEDDSSLYEAS 67

  Fly    73 LESMAKLIRASTTSMTSVPKPLKFMRPHYETMKTVYKHMPNEQARQLCADIISVLSMTMG-SGK- 135
            |.::.:.|:.||:|||:|||||||:||.|..:.::|....:...:...||::|:|:||.. :||
Yeast    68 LNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLSILAMTYSENGKH 132

  Fly   136 DCLAYRFLCDRKQRIGDWGHEYVRHLSGEISAHYHD----------------------TTG-DF- 176
            |.|.||.|.|.....| |||||:|||:.||...|:|                      |:| :|
Yeast   133 DSLRYRLLSDVSDFEG-WGHEYIRHLALEIGEVYNDQVEKDAEDETSSDGSKSDGSAATSGFEFS 196

  Fly   177 RVQLIELVKQIIPYNMEHNAEADACDLLIEIDHLHLLSDFVDESAYPRVCLYLQSCYPYVPDPDN 241
            :...:.|...|:||.::||.|.||.|||:||:.:..|..||||:.:.|||.|:.:|.|.:|.|::
Yeast   197 KEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDENTFQRVCQYMVACVPLLPPPED 261

  Fly   242 TIILETALQLSRKFNQYTQAMRLALMLNDMDKIGEIFKEPKEPAMQKQLAFMLARQQICLELDEL 306
            ...|:||..:....|:.|.|:.||:.|.:.|.|..:|....:|.|.||||::||.|:...|
Yeast   262 VAFLKTAYSIYLSQNELTDAIALAVRLGEEDMIRSVFDATSDPVMHKQLAYILAAQKTSFE---- 322

  Fly   307 VPDYDDLMEIMSNANLNKHFLNLARELDIMEPKTPEDIYKSHLDNSRSRFASIQVDSAKQNLAAS 371
               |:.:.:|:.|..|::|||.||:||::..||.||||||||||||:|.|:|..:|||:||||:|
Yeast   323 ---YEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKSHLDNSKSVFSSAGLDSAQQNLASS 384

  Fly   372 FVNGFVNAGFGVDKLLSEDGNKWLYKNKEHGMLSATASLGLILLWDVDGGLTMIDKYLYSTDDNI 436
            |||||:|.|:..|||:.::.| |:||.|..||.||.||:|.|..|::| ||..:|||||..:..:
Yeast   385 FVNGFLNLGYCNDKLIVDNDN-WVYKTKGDGMTSAVASIGSIYQWNLD-GLQQLDKYLYVDEPEV 447

  Fly   437 KSGALLACGIVNCGIRN-EVDPAHALLSDYIDNQNSCMRVGAILGLGIAYAGSNRSIVIDTLKTV 500
            |:||||..||...|:.: ||:||..||.||:.|.::.:...||||||||:|||....|:..|..:
Yeast   448 KAGALLGIGISASGVHDGEVEPALLLLQDYVTNPDTKISSAAILGLGIAFAGSKNDEVLGLLLPI 512

  Fly   501 FSFGSNNKSSASVEILGITALSLGLISVGSCNSEITEILLQTIMGLTKADLKDTYTRFLFLGLGL 565
            .:     .:...:|...:.:|:|..:.||:||.:||..::...:..|..:||..:.|||.|.||:
Yeast   513 AA-----STDLPIETAAMASLALAHVFVGTCNGDITTSIMDNFLERTAIELKTDWVRFLALALGI 572

  Fly   566 LYLGRQKSTEAVMMTLEVLEEPYRSMATTMVDICAYAGTGNVLKIQQLLHIC----------SDH 620
            ||:|:.:..:.|:.|:..:|.|..|....:|..|||.|||:||.||.|||..          :|.
Yeast   573 LYMGQGEQVDDVLETISAIEHPMTSAIEVLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDADE 637

  Fly   621 YETS-----------------------------------------------------SADDEKEK 632
            .||:                                                     |.:.|:.|
Yeast   638 EETAEGQTNSISDFLGEQVNEPTKNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIK 702

  Fly   633 SKKDKGKDKEKE-----KEKEKEKEREKDLSATQSIAVLGIALIAMGEDIGAEMAYRSFGNLLRY 692
            |::.|||..:|:     |..::|:|:|..:....:.|||||||||:|||||.||:.|.||:|:.|
Yeast   703 SEEKKGKSSDKDATTDGKNDDEEEEKEAGIVDELAYAVLGIALIALGEDIGKEMSLRHFGHLMHY 767

  Fly   693 CEPAIRRAVPLALGLISASNPKLNIIDTLSKFSHDSDAEVAHNAIFAMGLVGAGTNNARLASMLR 757
            ....|||.||||:|::|.|:|::.:.|||::||||:|.||:.|:||||||.||||||||||.:||
Yeast   768 GNEHIRRMVPLAMGIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNARLAQLLR 832

  Fly   758 QLAQYHSKDPSNLFMVRIAQSLTHLGKGTLSLSPYHSDRQLMNPMAVAGLMATLVSLLDVKNLIL 822
            |||.|:|::...||:.|:||.|.||||||:::..: :|..::|.:.:|.::.|.|.|:....::
Yeast   833 QLASYYSREQDALFITRLAQGLLHLGKGTMTMDVF-NDAHVLNKVTLASILTTAVGLVSPSFML- 895

  Fly   823 NRSHYLLYTLVPAMQARMLITFDEELNQLQVPVRVGIAIDVVGQAGKPKTITGFQTHTTPVLLAI 887
             :.|.|.|.|...::.:.::..::|...::|.||||.|::.|||||:||.|||:.|.:|||||..
Yeast   896 -KHHQLFYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVGQAGRPKKITGWITQSTPVLLNH 959

  Fly   888 GERAELATDEYLALTPVMEGFVILKKNPNF 917
            ||||||.||||::.|..:||.|||||||::
Yeast   960 GERAELETDEYISYTSHIEGVVILKKNPDY 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn1	NP_649158.1	RPN1	61..919	CDD:227441	386/952 (41%)
RPN1	NP_011892.1	RPN1	1..993	CDD:227441	406/1005 (40%)