Protein Alignment Rpn1 and Psmd2

DIOPT Version :10

• Sequence 1: NP_649158.1
• Gene: Rpn1 / 40174
• FlyBaseID: FBgn0028695
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001026809.1
• Gene: Psmd2 / 287984
• RGDID: 1305752
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 918
• Identity: 565/918 - (61%)
• Similarity: 727/918 - (79%)
• Gaps: 19/918 - (2%)

  Fly     3 GETKLEKKPLKPAASEGDAKDPKAKKDEKKDGKDKEQQPELSDEDQQLQEELELLVQHLQEPDAK 67
            |..|...:..:|:|:.....|.|:...|::|..:|:::.|||:||:|||:|||:||:.|.|.|..
  Rat     5 GRDKTPVQSQQPSATAPSGADEKSSGKERRDAGEKDKEQELSEEDKQLQDELEMLVERLGEKDTS 69

  Fly    68 LYQPTLESMAKLIRASTTSMTSVPKPLKFMRPHYETMKTVYKHMPNEQARQLCADIISVLSMTMG 132
            ||:|.||.:.:.||:||||||||||||||:||||..:|.:|::|...:.:...|||||||:|||.
  Rat    70 LYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKCFAADIISVLAMTMS 134

  Fly   133 SGKDCLAYRFLCDRKQRIGDWGHEYVRHLSGEISAHYHDTTGDFRVQ---LIELVKQIIPYNMEH 194
            ..::||.|| |...::.:..|||||||||:||::..:.:.....:.|   |:.|||:|:||||.|
  Rat   135 GERECLKYR-LVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKAQREPLLTLVKEIVPYNMAH 198

  Fly   195 NAEADACDLLIEIDHLHLLSDFVDESAYPRVCLYLQSCYPYVPDPDNTIILETALQLSRKFNQYT 259
            |||.:|||||:||:.:.:|...:||:||.:|||||.||..|||:|:|:.:|..||.:.|||:::.
  Rat   199 NAEHEACDLLMEIEQVDMLEKDIDENAYSKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFP 263

  Fly   260 QAMRLALMLNDMDKIGEIFKEPKEPAMQKQLAFMLARQQICLELDELVPDYDDLMEIMSNANLNK 324
            :|:|||||||||:.:.:||...|:..:|||:||||.|..:.|||.|.|.:|:||.|||||..||.
  Rat   264 EALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNS 328

  Fly   325 HFLNLARELDIMEPKTPEDIYKSHLDNSRSRFASIQVDSAKQNLAASFVNGFVNAGFGVDKLLSE 389
            :||.|||||||||||.|:||||:||:|:|...:..|||||:.|||:|||||||||.||.||||::
  Rat   329 NFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTD 393

  Fly   390 DGNKWLYKNKEHGMLSATASLGLILLWDVDGGLTMIDKYLYSTDDNIKSGALLACGIVNCGIRNE 454
            ||||||||||:||||||.||||:|||||||||||.|||||||::|.|||||||||||||.|:|||
  Rat   394 DGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNE 458

  Fly   455 VDPAHALLSDYIDNQNSCMRVGAILGLGIAYAGSNRSIVIDTLKTVFSFGSNNKSSASVEILGIT 519
            .|||.||||||:.:.::.||:|:|.|||:|||||||..|:..|..|.     ..|.:|:|:.|:|
  Rat   459 CDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVM-----GDSKSSMEVAGVT 518

  Fly   520 ALSLGLISVGSCNSEITEILLQTIMGLTKADLKDTYTRFLFLGLGLLYLGRQKSTEAVMMTLEVL 584
            ||:.|:|:|||||.::|..:|||||..::.:|||||.|:|.|||||.:||:.::.||::..|||:
  Rat   519 ALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVV 583

  Fly   585 EEPYRSMATTMVDICAYAGTGNVLKIQQLLHICSDHYETSSADDEKEKSKKDKGKDKEKEKEKEK 649
            .||:||.|.|:||:|||||:|||||:||||||||:|:      |.||   |::.|||:::|:|:|
  Rat   584 SEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHF------DSKE---KEEDKDKKEKKDKDK 639

  Fly   650 EKEREKDLSATQSIAVLGIALIAMGEDIGAEMAYRSFGNLLRYCEPAIRRAVPLALGLISASNPK 714
             ||...|:.|.|.:||||||||||||:||||||.|:||:||||.||.:||||||||.|||.|||:
  Rat   640 -KEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPR 703

  Fly   715 LNIIDTLSKFSHDSDAEVAHNAIFAMGLVGAGTNNARLASMLRQLAQYHSKDPSNLFMVRIAQSL 779
            |||:|||||||||:|.||::|:|||||:||:||||||||:|||||||||:|||:||||||:||.|
  Rat   704 LNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGL 768

  Fly   780 THLGKGTLSLSPYHSDRQLMNPMAVAGLMATLVSLLDVKNLILNRSHYLLYTLVPAMQARMLITF 844
            ||||||||:|.|||||||||:.:|||||:..|||.|||:|:||.:|||:||.||.|||.|||:||
  Rat   769 THLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTF 833

  Fly   845 DEELNQLQVPVRVGIAIDVVGQAGKPKTITGFQTHTTPVLLAIGERAELATDEYLALTPVMEGFV 909
            ||||..|.|.||||.|:|||||||||||||||||||||||||.||||||||:|:|.:||::||||
  Rat   834 DEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFV 898

  Fly   910 ILKKNPNF 917
            ||:||||:
  Rat   899 ILRKNPNY 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn1	NP_649158.1	RPN1	61..919	CDD:227441	543/860 (63%)
Psmd2	NP_001026809.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51		14/45 (31%)
		RPN1	7..906	CDD:227441	563/914 (62%)
		PC 1	409..442		26/32 (81%)
		PC 2	443..479		24/35 (69%)
		PC 3	480..514		17/38 (45%)
		PC 4	517..551		16/33 (48%)
		PC 5	560..589		14/28 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..645		11/25 (44%)
		PC 6	692..723		24/30 (80%)
		Required for interaction with UBLCP1. /evidence=ECO:0000250|UniProtKB:Q13200	708..903		150/194 (77%)