DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FIGNL2 and fignl2

DIOPT Version :9

Sequence 1:	XP_016874787.1	Gene:	FIGNL2 / 401720	HGNCID:	13287	Length:	767	Species:	Homo sapiens
Sequence 2:	NP_001201837.1	Gene:	fignl2 / 561837	ZFINID:	ZDB-GENE-090313-189	Length:	684	Species:	Danio rerio

Alignment Length:	722	Identity:	312/722 - (43%)
Similarity:	410/722 - (56%)	Gaps:	103/722 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   102 PAVPITECTALLKMHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLEL-PPGGRQRCHYAWAHDDI 165
            |.||.    :||||||.|||||||:|||||||||||||.|||||.|| ...||....||||:|||
Zfish     4 PIVPY----SLLKMHWNPEHAQPLSQWPEQHLDVSSTTSSPAHKSELYSSRGRGSYSYAWANDDI 64

Human   166 SALTASNLLKRYAEKYSGVLDSPYERPALGGYSD-ASF--LNGA-KGDPEPWP---GPEPPYPLA 223
            ||||||||||||||||||:||||||||::|.|.: .:|  |||. |.:.||||   ..:..|.|.
Zfish    65 SALTASNLLKRYAEKYSGMLDSPYERPSVGAYPEPGAFGGLNGGQKSELEPWPLTHSTDGAYSLV 129

Human   224 --SLHEGLPGTK----SGGGGGSGALGGSPVLAGNLPEPLYAG-NACGGPSAAPEYAAGYGGGYL 281
              |.||.|.|.|    |.|..|||.:.   .:..||.:..|:| ::|.||.:: ||...|.|.||
Zfish   130 PPSSHESLSGPKVVPTSAGPPGSGNVS---AVNSNLSDSGYSGSSSCSGPHSS-EYPPSYNGTYL 190

Human   282 APGYCAQTGAALPPPPPAAL--LQPPPP--PGYGPSAPLYNYPAGGYAAQPGYGALPPPPGPPPA 342
            :.|||.|..:||   |||:|  |||.|.  |.|..:||:||||...|..|.|   |.|....|.|
Zfish   191 SSGYCPQPSSAL---PPASLHALQPNPTLLPSYTTTAPVYNYPPSTYPHQTG---LAPSYTHPTA 249

Human   343 PYLTPGLPAPTPLPAPAPPT----AYGFP-TAAPGAESGLSLKRKA------ADEGPEGRYRKYA 396
            ||:        |.|.|:.||    :||:. ::..|:|.|.||||||      .::....|||||:
Zfish   250 PYI--------PSPLPSRPTVVGGSYGYQNSSVGGSEPGGSLKRKAFEMTLDEEDSDSSRYRKYS 306

Human   397 YEPAKAPVADGASYPAADNGECRGNGFRA--------KPPGAAEEAS------GKYGGGVPLKVL 447
            |:|.|  ....:.|...|..   ||||..        ||...:.::|      |||.|   ||.|
Zfish   307 YDPMK--TGGDSPYGVTDKA---GNGFGTGSTDPQGFKPSKPSSQSSLEGDEVGKYSG---LKPL 363

Human   448 GSPVYGPQLE---PFEKFPERAPAPRG---GFAVPSGETPKGVDPGALELVTSKMVDCGPPVQWA 506
            .||.||...:   |.....|...|.:|   ..:....:..|.::|..||||:.::.||.|.:.|.
Zfish   364 VSPTYGAAGDYSPPAAMTGENGGAEQGFSQNRSQKRSDPMKSIEPRMLELVSRELQDCSPAMLWT 428

Human   507 DVAGQGALKAALEEELVWPLLRP-PAYPGSLRPPRTVLLFGPRGAGKALLGRCLATQLGATLLRL 570
            ::||...:||||||:|:||:||| ||    :.||:|:|||||:|.||..|.|.|::|:||:..||
Zfish   429 ELAGNCHIKAALEEDLLWPVLRPNPA----IHPPKTILLFGPQGGGKTTLARSLSSQIGASFYRL 489

Human   571 RGATLAAPGAAEGARLLQAAFAAARCRPPSVLLISELEALLPARDDGAAAGGALQVPLLACLDGG 635
            ..||||:....|..:||...|:.|..|.|:::|:||:||:   .::|      |:..|.|.|:..
Zfish   490 SCATLASKLKGEAEQLLLTLFSVATARQPAMVLLSEVEAI---EEEG------LRQQLQAQLEKI 545

Human   636 CGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVALPDSPARGQILQRALAQQGCALSERELAAL 700
            ....::..|||.||.||..:.::..|.||.|:::.|||...|..:|.:|||.|||:||||||:|:
Zfish   546 QHNQSNQFLVVCTTRRPDLIKDSLLRCFSKRYHIGLPDGNTRRHVLLQALAPQGCSLSERELSAV 610

Human   701 VQGTQGFSGGELGQLCQQAAAGA---------GLPGLQRPLSYKDLEAALAKVGPRASAKELDSF 756
            :|.::|||..||.||||||.|.|         .||......:.:|.|.|..||.|.::.||||:.
Zfish   611 LQRSEGFSVWELLQLCQQALASASASASVPLHSLPASLSSPTLQDFENAFCKVRPHSTPKELDTC 675

Human   757 VEWDKMY 763
            :||.|:|
Zfish   676 MEWSKVY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FIGNL2	XP_016874787.1	None
fignl2	NP_001201837.1	AAA	457..583	CDD:214640	52/134 (39%)
fignl2	NP_001201837.1	AAA	461..581	CDD:278434	48/128 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330473
Domainoid	1	1.000	300	1.000	Domainoid score	I7470
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	451	1.000	Inparanoid score	I7161
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG42377
OrthoDB	1	1.010	-	-		D1193464at2759
OrthoFinder	1	1.000	-	-		FOG0009205
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_123790
Panther	1	1.100	-	-	LDO	PTHR23074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8135
SonicParanoid	1	1.000	-	-		X10848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	12	12.440