Protein Alignment Prp3 and PRPF3

DIOPT Version :10

• Sequence 1: NP_649156.1
• Gene: Prp3 / 40172
• FlyBaseID: FBgn0036915
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_004689.1
• Gene: PRPF3 / 9129
• HGNCID: 17348
• Length: 683
• Species: Homo sapiens
• Alignment Length: 625
• Identity: 314/625 - (50%)
• Similarity: 405/625 - (64%)
• Gaps: 75/625 - (12%)

  Fly    10 GDDQKLSKKRAAASDSKSGGGSALEAPKKSRFDVPEKNGGGGEKKEEVAV--------PASLSST 66
            |||.::||:           .|.::..:..||:         |.:||..|        |..|:..
Human    96 GDDSEISKE-----------SSGVKKRRIPRFE---------EVEEEPEVIPGPPSESPGMLTKL 140

  Fly    67 QIKLMMAHAQREIEERKRALSNLRDKDPLLASVPSIG----MPVALATQALAKKPTPEDS-EKAR 126
            |||.||..|.|:|||||:.||.:....| ....||..    :|:....|.........|: ||||
Human   141 QIKQMMEAATRQIEERKKQLSFISPPTP-QPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKAR 204

  Fly   127 KIAELQAQIRAKL--------TGNLASLIQPTAVA-AAAAAAAQAQERPKPLILDDEGRTVDKSG 182
            |.|||||:|:|:|        ..|:..|....|:. |......:.|.:|.|||||::|||||.:|
Human   205 KAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATG 269

  Fly   183 RTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLR 247
            :.|.:....|||||||||.|||.|::|  |.|:    .|...|:..:||.|:::.|:.|.:||.:
Human   270 KEIELTHRMPTLKANIRAVKREQFKQQ--LKEK----PSEDMESNTFFDPRVSIAPSQRQRRTFK 328

  Fly   248 FHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPD-DVPAMEWWDSV 311
            ||:.|||:::|:|:|.|:|||:||.||||.||||||.::|:|||||||:::.: |:|.:|||||.
Human   329 FHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSY 393

  Fly   312 I------LTQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRR 370
            |      ||::....:|..|        ||||:|||.|:.||.:...||.|.|:|||||:|||||
Human   394 IIPNGFDLTEENPKREDYFG--------ITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR 450

  Fly   371 QNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDAN 435
            |.||||.||.|||:||||:.|||||:||||||||||:||||||||:|.|||.||||||||||:||
Human   451 QTRREAQKELQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEAN 515

  Fly   436 NARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDC 500
            .|||||:||:..||.:||:||.|.|||:||||:|:| .|.:||||:|.||.||.:||.|||.:|.
Human   516 AARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNL-SNPAKKFKIEANAGQLYLTGVVVLHKDV 579

  Fly   501 CVVVVEGGPKQQKKYRRLMLTRIKWEE--DNAKGNDGQD-------VPNSCVLVWEGTSQRRHFG 556
            .|||||||||.|||::||||.||||:|  .|.||:|.::       ..|.||||||||::.|.||
Human   580 NVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFG 644

  Fly   557 EIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTD 596
            |:|||..|.|.||||.|:||..|||||||.|.:||| |||
Human   645 EMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLE-STD 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:462524	131/218 (60%)
		DUF1115	464..585	CDD:461943	77/129 (60%)
PRPF3	NP_004689.1	PWI	3..73	CDD:214609
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	73..135		12/58 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	153..183		10/30 (33%)
		PRP3	308..521	CDD:462524	131/220 (60%)
		Mediates interaction with SART3. /evidence=ECO:0000269|PubMed:15314151	416..550		96/133 (72%)
		DUF1115	544..673	CDD:461943	77/129 (60%)