DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp3 and PRP3

DIOPT Version :9

Sequence 1:	NP_649156.1	Gene:	Prp3 / 40172	FlyBaseID:	FBgn0036915	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_010761.3	Gene:	PRP3 / 852084	SGDID:	S000002881	Length:	469	Species:	Saccharomyces cerevisiae

Alignment Length:	478	Identity:	124/478 - (25%)
Similarity:	205/478 - (42%)	Gaps:	133/478 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 QERP--KPLILDDEGRTVDK---SGRTINIPTVTPTLKANIRAKKREVFQRQTG----LGERSES 218
            |..|  ||..|..|..|.|:   .|..:.....:....:|:...:|..   |||    |.:..:.
Yeast    15 QNSPYYKPSFLRREETTNDEEKFQGHGLKTELHSALKSSNLNLIRRTY---QTGENPYLSDPHDR 76

  Fly   219 GTSAQEEAIKYFDDRIALKPTVRTKRTLRFHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGI 283
            |:|::      |:.|.        :|.|:|::.|   ::::|:..:..|::.|.| .::.||
Yeast    77 GSSSR------FNRRY--------ERGLKFYQKG---EISKRIAQERTLQKQQEE-EELKRK--- 120

  Fly   284 SSATKLALIAPKQDMPD--------DVPAM------------------------EWWDSVI---- 312
                    :..::|..|        |:|.:                        ||||:..
Yeast   121 --------LKQEEDEKDKRKLIESGDLPNLELHEDKFLLDLSKFKIYYDNNHGYEWWDTAYLDEK 177

  Fly   313 ------------------LTQDLETVDDASG--KISIRQTAITNLIEHPTQMKPPNEPLKPVYLP 357
                              |.:|::.|||...  ..|||..|      ||...| .||  ..|.:.
Yeast   178 GELMEKYDMNGTSPAEEKLAEDIDEVDDDDDDEHPSIRYVA------HPLPEK-INE--AKVSIK 233

  Fly   358 VFLTKKERKKLRRQNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVL-GSEAVQDPTKMEQHVR 421
            .:||:.|||:|||..|:.|.:..:.||:|||:..||||:::||:|.|. ..:.:.|||..|:.|:
Yeast   234 AYLTQHERKRLRRNRRKMAREAREIKIKLGLLPKPEPKVKLSNMMSVFENDQNITDPTAWEKVVK 298

  Fly   422 DQMAKRQKAHEDANNARKLTSEQKSEKKQRKLREDTSCGV------HVSVYRIRDLQDNQSKKFK 480
            ||:..|::.|.:.|       |::.|...::.:|..:..|      |..|::.::|| |...:||
Yeast   299 DQVDLRKRKHLEEN-------ERRHEDAIKRRKEAVNMNVEKPTVYHCKVFQFKNLQ-NPKIRFK 355

  Fly   481 VETNAKQLQMTGSVVLFRD--CCVVVVEGGPKQQKKYRRLMLTRIKWEEDNAKGNDGQDVP---- 539
            ::.|:|:|.:.|..:..||  ..:::|.|..|..|.|..|::.||||.||.....:..|:.
Yeast   356 LKMNSKELSLKGLCLRIRDDGPGIIIVVGNEKSCKFYENLVMKRIKWNEDFELHTNTGDIKMDMH 420

  Fly   540 -NSCVLVWEGTSQRRHFGEIKFK 561
             ||....|||..|     :.|||
Yeast   421 NNSISKTWEGYLQ-----DCKFK 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:285741	68/268 (25%)
Prp3	NP_649156.1	DUF1115	466..585	CDD:284060	33/103 (32%)
PRP3	NP_010761.3	PRP3	67..317	CDD:400749	72/294 (24%)
PRP3	NP_010761.3	DUF1115	342..464	CDD:399506	33/103 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346230
Domainoid	1	1.000	75	1.000	Domainoid score	I2143
eggNOG	1	0.900	-	-		E1_KOG2769
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I1335
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52127
OrthoFinder	1	1.000	-	-		FOG0004423
OrthoInspector	1	1.000	-	-		oto99616
orthoMCL	1	0.900	-	-		OOG6_102616
Panther	1	1.100	-	-	LDO	PTHR14212
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2239
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.830