DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prp3 and Prpf3

DIOPT Version :10

Sequence 1:NP_649156.1 Gene:Prp3 / 40172 FlyBaseID:FBgn0036915 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_081817.2 Gene:Prpf3 / 70767 MGIID:1918017 Length:683 Species:Mus musculus


Alignment Length:625 Identity:313/625 - (50%)
Similarity:404/625 - (64%) Gaps:75/625 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GDDQKLSKKRAAASDSKSGGGSALEAPKKSRFDVPEKNGGGGEKKEEVAV--------PASLSST 66
            |||.::||:           .|.::..:..||:         |.:||..|        |..|:..
Mouse    96 GDDSEISKE-----------SSGVKKRRIPRFE---------EVEEEPEVIPGPPSESPGMLTKL 140

  Fly    67 QIKLMMAHAQREIEERKRALSNLRDKDPLLASVPSIG----MPVALATQALAKKPTPEDS-EKAR 126
            |||.||..|.|:|||||:.||.:....| ....||..    :|:....|.........|: ||||
Mouse   141 QIKQMMEAATRQIEERKKQLSFISPPAP-QPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKAR 204

  Fly   127 KIAELQAQIRAKL--------TGNLASLIQPTAVA-AAAAAAAQAQERPKPLILDDEGRTVDKSG 182
            |.|||||:|:|:|        ..|:..|....|:. |......:.|.:|.|||||::|||||.:|
Mouse   205 KAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATG 269

  Fly   183 RTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLR 247
            :.:.:....|||||||||.|||.|::|  |.|:    .|...|:..:||.|:::.|:.|.:||.:
Mouse   270 KEVELTHRMPTLKANIRAVKREQFKQQ--LKEK----PSEDMESNTFFDPRVSIAPSQRQRRTFK 328

  Fly   248 FHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPD-DVPAMEWWDSV 311
            ||:.|||:::|:|:|.|:|||:||.||||.||||||.::|:|||||||:::.: |:|.:|||||.
Mouse   329 FHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSY 393

  Fly   312 I------LTQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRR 370
            |      ||::....:|..|        ||||:|||.|:.||.:...||.|.|:|||||:|||||
Mouse   394 IIPNGFDLTEENPKREDYFG--------ITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR 450

  Fly   371 QNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDAN 435
            |.||||.||.|||:||||..|||||:||||||||||:||||||||:|.|||.||||||||||:||
Mouse   451 QTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEAN 515

  Fly   436 NARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDC 500
            .|||||:||:..||.:||:||.|.|||:||||:|:| .|.:||||:|.||.||.:||.|||.:|.
Mouse   516 AARKLTAEQRKVKKIKKLKEDISQGVHISVYRVRNL-SNPAKKFKIEANAGQLYLTGVVVLHKDV 579

  Fly   501 CVVVVEGGPKQQKKYRRLMLTRIKWEE--DNAKGNDGQD-------VPNSCVLVWEGTSQRRHFG 556
            .|||||||||.|||::||||.||||:|  .|.||:|.::       ..|.||||||||::.|.||
Mouse   580 NVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFG 644

  Fly   557 EIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTD 596
            |:|||..|.|.||||.|:||..|||||||.|.:||| |||
Mouse   645 EMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLE-STD 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Prp3NP_649156.1 PRP3 229..441 CDD:462524 131/218 (60%)
DUF1115 464..585 CDD:461943 77/129 (60%)
Prpf3NP_081817.2 PWI 3..73 CDD:214609
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..135 12/58 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..183 4/22 (18%)
PRP3 308..521 CDD:462524 131/220 (60%)
Mediates interaction with SART3. /evidence=ECO:0000250|UniProtKB:O43395 416..550 96/133 (72%)
DUF1115 544..673 CDD:461943 77/129 (60%)
Blue background indicates that the domain is not in the aligned region.

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