DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp3 and ppp1r42

DIOPT Version :9

Sequence 1:	NP_649156.1	Gene:	Prp3 / 40172	FlyBaseID:	FBgn0036915	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_001002202.1	Gene:	ppp1r42 / 431749	ZFINID:	ZDB-GENE-040704-43	Length:	329	Species:	Danio rerio

Alignment Length:	179	Identity:	38/179 - (21%)
Similarity:	72/179 - (40%)	Gaps:	44/179 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 EWWDSVIL---------------TQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVY 355
            |.||...|               .|:||||.....|:     .:.:|..:|...||.... :.:.
Zfish   161 ELWDLAPLRKMTHLFAADNQLHDIQELETVFSQWFKL-----RLLDLSRNPVCHKPKYRD-RLIT 219

  Fly   356 LPVFLTKKERKKLRRQNRR-----EAWKEEQEKIRLGLVAPPEPKLRISNLMRV-----LGSEAV 410
            :..||...:.|::...:|:     :|.|:.::|...|    .:.||:::|.:..     ||.
Zfish   220 VCKFLDDLDGKQINELSRQFLINWKASKDAKKKPEDG----KDNKLQVANQLSTSADFHLGP--- 277

  Fly   411 QDPTKMEQHVRDQMAKRQKAHEDANNARKLTSEQ-KSEKKQRKLREDTS 458
            |.|:     ||::.:...|..|:........::| :::.:.|..|.|:|
Zfish   278 QHPS-----VRERSSSLSKPSENEKPGVTFRTDQIQADSRGRGTRGDSS 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:285741	33/159 (21%)
Prp3	NP_649156.1	DUF1115	466..585	CDD:284060
ppp1r42	NP_001002202.1	LRR_RI	29..>207	CDD:238064	11/50 (22%)
		LRR_4	30..69	CDD:289563
		LRR 1	30..51
		leucine-rich repeat	31..52	CDD:275380
		LRR_8	51..107	CDD:290566
		LRR_4	52..93	CDD:289563
		LRR 2	52..73
		leucine-rich repeat	53..74	CDD:275380
		LRR_4	74..115	CDD:289563
		LRR 3	74..95
		leucine-rich repeat	75..96	CDD:275380
		LRR 4	96..117
		leucine-rich repeat	97..118	CDD:275380
		LRR 5	118..139
		leucine-rich repeat	119..144	CDD:275380
		leucine-rich repeat	145..170	CDD:275380	4/8 (50%)
		LRR 6	148..169		3/7 (43%)
		LRR 7	170..191		4/20 (20%)
		leucine-rich repeat	171..196	CDD:275380	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..329		13/62 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2769
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900