DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prp3 and prpf3

DIOPT Version :9

Sequence 1:	NP_649156.1	Gene:	Prp3 / 40172	FlyBaseID:	FBgn0036915	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_991311.2	Gene:	prpf3 / 403072	ZFINID:	ZDB-GENE-040823-3	Length:	699	Species:	Danio rerio

Alignment Length:	612	Identity:	311/612 - (50%)
Similarity:	405/612 - (66%)	Gaps:	68/612 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SALEAPKKSRFDVPEKNGGGGEKKEEVAV-------PASLSSTQIKLMMAHAQREIEERKRALS- 87
            ||::..:..||:         |.:|.|.:       |..|:..|||.||..|.|:|||||:.||
Zfish   110 SAVKKKRVPRFE---------EVEEPVVLPGPPTESPGMLTKIQIKQMMEAATRQIEERKKQLSF 165

  Fly    88 ---NLRDKDPLLASVPSIGMPVAL-----ATQALAKKPTP----EDSEKARKIAELQAQIRAKLT 140
               ....:..|.||......|.::     |||::|.....    :..|||||.|||||:|::.|:
Zfish   166 AAPTPSSQSRLSASQTDSSTPRSMNQAGGATQSIAPSQAANFMNDAIEKARKAAELQAKIQSTLS 230

  Fly   141 ---GNLASLIQP---TAVAAA-------AAAAAQAQE--RPKPLILDDEGRTVDKSGRTINIPTV 190
               |.||::..|   ..||.|       |....:.:|  :|.|||||:.|||||.||:.|.:...
Zfish   231 MKPGILATVGNPGPHNMVALANLHAMGIAPPKVEPREITKPTPLILDELGRTVDASGKEIELTHR 295

  Fly   191 TPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLRFHEPGKFQ 255
            .|||||||||.|||.|::|  |.|:    .|...|:..|||.|:||.|.::.|:..||||.|:|:
Zfish   296 MPTLKANIRAVKREQFRQQ--LKEK----PSDDLESTSYFDPRVALAPALKPKKGFRFHEQGRFE 354

  Fly   256 QLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPD-DVPAMEWWDSVILTQDLE- 318
            ::|:|:|.|:|||:||.||:|.|:||||.::|||||||||:::.: ::|.:|||||.||...:.
Zfish   355 KIAQRIRTKAQLEKLQMEIAQAAKKTGIQASTKLALIAPKKELGEGEIPNIEWWDSYILPFHINL 419

  Fly   319 ----TVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRRQNRREAWKE 379
                .:|:      :....:|||:||||||.||.:..|||.|.|:|||||:||||||.|||..||
Zfish   420 SAHTNLDE------VEMHGVTNLVEHPTQMAPPVDTDKPVTLGVYLTKKEQKKLRRQTRREGQKE 478

  Fly   380 EQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDANNARKLTSEQ 444
            .|||:||||:.|||||:||||||||||:||||.|||:|.|||.||||||||||:||.|||||:||
Zfish   479 VQEKVRLGLMPPPEPKVRISNLMRVLGTEAVQGPTKVEAHVRAQMAKRQKAHEEANAARKLTAEQ 543

  Fly   445 KSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDCCVVVVEGGP 509
            :.|||.:||:||.|.|||::|||||:|. |.:||||||.||.||.:||:|||.:|..:|||||||
Zfish   544 RKEKKVKKLKEDLSHGVHIAVYRIRNLH-NPAKKFKVEANANQLYLTGTVVLHKDVNIVVVEGGP 607

  Fly   510 KQQKKYRRLMLTRIKWEEDNAKGNDGQDVP-----NSCVLVWEGTSQRRHFGEIKFKIFPMEKMA 569
            |.|||::|||||||||:|.|:|.::..|..     |.|.|||||||:.|::||:|||..|.|.||
Zfish   608 KAQKKFKRLMLTRIKWDEPNSKRDEHHDDDESRRNNRCSLVWEGTSKERNYGEVKFKQCPTENMA 672

  Fly   570 REFFQKHQVEHYWDLAYSGAVLEASTD 596
            ||.|:||..|||||||.|.:|||.:.|
Zfish   673 REHFKKHGTEHYWDLALSQSVLETTDD 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:285741	129/217 (59%)
Prp3	NP_649156.1	DUF1115	466..585	CDD:284060	75/123 (61%)
prpf3	NP_991311.2	PWI	9..76	CDD:279781
		PRP3	328..540	CDD:285741	129/217 (59%)
		DUF1115	565..688	CDD:284060	75/123 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595144
Domainoid	1	1.000	262	1.000	Domainoid score	I1912
eggNOG	1	0.900	-	-		E1_KOG2769
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3447
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1205
OMA	1	1.010	-	-		QHG52127
OrthoDB	1	1.010	-	-		D1322299at2759
OrthoFinder	1	1.000	-	-		FOG0004423
OrthoInspector	1	1.000	-	-		oto39797
orthoMCL	1	0.900	-	-		OOG6_102616
Panther	1	1.100	-	-	LDO	PTHR14212
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2239
SonicParanoid	1	1.000	-	-		X3705
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800