Protein Alignment Prp3 and Prpf3

DIOPT Version :10

• Sequence 1: NP_649156.1
• Gene: Prp3 / 40172
• FlyBaseID: FBgn0036915
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_001424817.1
• Gene: Prpf3 / 361995
• RGDID: 1310555
• Length: 683
• Species: Rattus norvegicus
• Alignment Length: 625
• Identity: 313/625 - (50%)
• Similarity: 404/625 - (64%)
• Gaps: 75/625 - (12%)

  Fly    10 GDDQKLSKKRAAASDSKSGGGSALEAPKKSRFDVPEKNGGGGEKKEEVAV--------PASLSST 66
            |||.::||:           .|.::..:..||:         |.:||..|        |..|:..
  Rat    96 GDDSEISKE-----------SSGVKKRRIPRFE---------EVEEEPEVIPGPPSESPGMLTKL 140

  Fly    67 QIKLMMAHAQREIEERKRALSNLRDKDPLLASVPSIG----MPVALATQALAKKPTPEDS-EKAR 126
            |||.||..|.|:|||||:.||.:....| ....||..    :|:....|.........|: ||||
  Rat   141 QIKQMMEAATRQIEERKKQLSFISPPAP-QPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKAR 204

  Fly   127 KIAELQAQIRAKL--------TGNLASLIQPTAVA-AAAAAAAQAQERPKPLILDDEGRTVDKSG 182
            |.|||||:|:|:|        ..|:..|....|:. |......:.|.:|.|||||::|||||.:|
  Rat   205 KAAELQARIQAQLALKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATG 269

  Fly   183 RTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLR 247
            :.:.:....|||||||||.|||.|::|  |.|:    .|...|:..:||.|:::.|:.|.:||.:
  Rat   270 KEVELTHRMPTLKANIRAVKREQFKQQ--LKEK----PSEDMESNTFFDPRVSIAPSQRQRRTFK 328

  Fly   248 FHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPD-DVPAMEWWDSV 311
            ||:.|||:::|:|:|.|:|||:||.||||.||||||.::|:|||||||:::.: |:|.:|||||.
  Rat   329 FHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDSY 393

  Fly   312 I------LTQDLETVDDASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRR 370
            |      ||::....:|..|        ||||:|||.|:.||.:...||.|.|:|||||:|||||
  Rat   394 IIPNGFDLTEENPKREDYFG--------ITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR 450

  Fly   371 QNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDAN 435
            |.||||.||.|||:||||..|||||:||||||||||:||||||||:|.|||.||||||||||:||
  Rat   451 QTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQKAHEEAN 515

  Fly   436 NARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDC 500
            .|||||:||:..||.:||:||.|.|||:||||:|:| .|.:||||:|.||.||.:||.|||.:|.
  Rat   516 AARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNL-SNPAKKFKIEANAGQLYLTGVVVLHKDV 579

  Fly   501 CVVVVEGGPKQQKKYRRLMLTRIKWEE--DNAKGNDGQD-------VPNSCVLVWEGTSQRRHFG 556
            .|||||||||.|||::||||.||||:|  .|.||:|.::       ..|.||||||||::.|.||
  Rat   580 NVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDDDEESDEEAVKKTNKCVLVWEGTAKDRSFG 644

  Fly   557 EIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTD 596
            |:|||..|.|.||||.|:||..|||||||.|.:||| |||
  Rat   645 EMKFKQCPTENMAREHFKKHGAEHYWDLALSESVLE-STD 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:462524	131/218 (60%)
		DUF1115	464..585	CDD:461943	77/129 (60%)
Prpf3	NP_001424817.1	None