DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp3 and prp3

DIOPT Version :9

Sequence 1:	NP_649156.1	Gene:	Prp3 / 40172	FlyBaseID:	FBgn0036915	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_594560.1	Gene:	prp3 / 2541686	PomBaseID:	SPAC29E6.02	Length:	542	Species:	Schizosaccharomyces pombe

Alignment Length:	602	Identity:	182/602 - (30%)
Similarity:	288/602 - (47%)	Gaps:	89/602 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DGDDQKL--SKKRAAASDSKSGGGSALEAPKKSRFDVPEKNGGGG----EKKEEVAVPASLSSTQ 67
            |.:.::|  |:.|.::|.:.....:|:|..|:.|..:.::.....    ||:.|....|.:.:.|
pombe     2 DRNKRRLESSQLRESSSPNSQNKPNAMEEIKRRRLQLEQRLAQQAQVPWEKRSENGNNAGMETIQ 66

  Fly    68 IKLMMAHAQREIEER--KRALSNLRDKDPLLASVPSIGMPVALATQALAKKPTPEDSEKARKIAE 130
            .::      .|::|:  ||..:|:...:.|..                      :||..|:  ..
pombe    67 NRI------SELKEKTAKRFNANIPKSEGLFR----------------------DDSNGAK--GG 101

  Fly   131 LQAQIR-AKLTGNLASLIQPTAVAAAAAAAAQAQERPKPLILDDEGRTVDKSGRTINIPTVTPTL 194
            |:..|. ..|.||    ||.|                   ||..|.|.     ||.:..|...:|
pombe   102 LKVGIHPVLLDGN----IQNT-------------------ILTPENRK-----RTASFSTKGVSL 138

  Fly   195 KANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALKPTVRTKRTLRFHEPGKFQQLAE 259
            ..:...|...:.::...|    ::..:.:.|...::|.|.......|..|.|..:|.|||.:.|.
pombe   139 SQHQLLKPPAITEQNPFL----DTAPTPRLEDSPFYDPRTKESRKTRGSRNLHLNESGKFIEEAN 199

  Fly   260 RMRMKSQLERLQNEISQIARKTGISSATKLALIAPKQDMPDDVPAMEWWDSVILTQDLETVDDAS 324
            :.|.:::||.|:..|:..:.|.||.....   |..|....|.:|.:||||...:....:..|:.:
pombe   200 QARRQARLEDLKKRIALHSHKAGIEDELD---ITSKSIGRDTIPNIEWWDLPFIKDYNDYGDENN 261

  Fly   325 GKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKKERKKLRRQNRREAWKEEQEKIRLGLV 389
            ..|...|:.|.:.|:||..:.||....:|....|||||||:||:|||.|.||.||:|::..||:.
pombe   262 WLIDGPQSIINSAIQHPIPVLPPYAKNQPSSHSVFLTKKEQKKIRRQTRAEARKEKQDRQLLGIE 326

  Fly   390 APPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQKAHEDANNARKLTSEQKSEKKQRKLR 454
            .|..||:::||||.|||.:|::||||:|..||.|:.:|:..||..|..||||.|::.||..||..
pombe   327 PPEPPKVKLSNLMHVLGDDAIKDPTKIEAEVRKQVEERRLRHERENEERKLTPEERKEKAFRKKD 391

  Fly   455 EDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGSVVLFRDCCVVVVEGGPKQQKKYRRLM 519
            ||::.|:...|:||:.|. ::..:.|::.||||...||..:|..:..:|:.|.|.|..||.:|||
pombe   392 EDSAAGLRCLVFRIKYLA-HRPHRLKIDLNAKQWGATGVCILNANFNLVIFEAGQKAIKKLKRLM 455

  Fly   520 LTRIKWEEDN-----AKGN-----DGQDV---PNSCVLVWEGTSQRRHFGEIKFKIFPMEKMARE 571
            |.||.|.:.:     |:||     :|:::   .|:|.|||||...||.|....|:..|.|..|:.
pombe   456 LERIDWTDTSRNSIIAQGNKLVDTEGRELNYTENTCNLVWEGEIGRRAFRYWSFRSCPSENDAKS 520

  Fly   572 FFQKH-QVEHYWDLAYS 587
            :.::. ..||:|.||.|
pombe   521 YLEEQGGAEHFWMLAKS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:285741	81/211 (38%)
Prp3	NP_649156.1	DUF1115	466..585	CDD:284060	45/132 (34%)
prp3	NP_594560.1	PRP3	168..361	CDD:285741	74/195 (38%)
prp3	NP_594560.1	DUF1115	403..535	CDD:284060	45/132 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	147	1.000	Domainoid score	I1128
eggNOG	1	0.900	-	-		E1_KOG2769
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3447
Inparanoid	1	1.050	229	1.000	Inparanoid score	I866
OMA	1	1.010	-	-		QHG52127
OrthoFinder	1	1.000	-	-		FOG0004423
OrthoInspector	1	1.000	-	-		oto101247
orthoMCL	1	0.900	-	-		OOG6_102616
Panther	1	1.100	-	-	LDO	PTHR14212
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2239
SonicParanoid	1	1.000	-	-		X3705
TreeFam	1	0.960	-	-
	14	13.860