DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prp3 and prp-3

DIOPT Version :9

Sequence 1:	NP_649156.1	Gene:	Prp3 / 40172	FlyBaseID:	FBgn0036915	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	NP_499300.1	Gene:	prp-3 / 176461	WormBaseID:	WBGene00010844	Length:	621	Species:	Caenorhabditis elegans

Alignment Length:	628	Identity:	245/628 - (39%)
Similarity:	332/628 - (52%)	Gaps:	118/628 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TRKDGDDQKLSKKRAAASDSKSGGGSALEAPKKSRFDVPEKNGGGGEKKEEVAVPASLSSTQ--- 67
            ||.|.|.:...:||....|                           .:|.:.:|||:::..|
Worm    70 TRTDRDGEDRDRKRDRTDD---------------------------RRKPDASVPAAVAEPQKPA 107

  Fly    68 ---------IKLMMAHAQREIEERKR----ALSNLRDKDPLLASVPSIGMP------------VA 107
                     .|.||..||:||||.||    |...|:.|..|..:...:..|            ..
Worm   108 EQSIEERLRAKEMMYKAQQEIEETKRKMAIAAGTLQPKAALAQAKTQMVAPGGKSLSLGRDEATM 172

  Fly   108 LATQALAKKPTPEDSEKARKIAELQAQIRAKLTGNLASLIQPTAVAAAAAAAAQAQERPKPLILD 172
            |.|.::.||         .::.||:|:           |.:.|.:|...|
Worm   173 LMTHSMDKK---------SRMEELKAR-----------LARTTVMAKIDA--------------- 202

  Fly   173 DEGRTVDKSGRTINIPTVTPTLKANIRAKKREVFQRQTGLGERSESGTSAQEEAIKYFDDRIALK 237
                .|..||..:..|     |...::..:::|.|:.|     .||  ...|:.|:|.|.||..:
Worm   203 ----MVGNSGAGVMAP-----LPEAVQQAEKKVQQQIT-----KES--KEPEKLIEYLDPRIQAR 251

  Fly   238 PTVRTKRTLRFHEPGKFQQLAERMRMKSQLERLQNEISQIARKTGISSATKLALIAP--KQDMPD 300
            ...|.:|...|||.|:|::||.:.|..::|||||||:|..|:.||||||.|||::.|  ...|.:
Worm   252 TADRRRRGFNFHEKGEFEKLANKQRAMAKLERLQNEVSSAAQSTGISSAVKLAMVTPTGTAKMEN 316

  Fly   301 DVPAMEWWDSVILTQDLETVDD--ASGKISIRQTAITNLIEHPTQMKPPNEPLKPVYLPVFLTKK 363
            .||.:||||.::|  |....|:  |...:......::.|:|||..|:.|.|||...||.|:||.|
Worm   317 GVPDIEWWDMLVL--DKVNYDEIPAENDMERYSQTVSELVEHPISMRAPTEPLTQQYLKVYLTTK 379

  Fly   364 ERKKLRRQNRREAWKEEQEKIRLGLVAPPEPKLRISNLMRVLGSEAVQDPTKMEQHVRDQMAKRQ 428
            |:||:|||||:|..||:.|||||||...||||::|||||||||:||:|||||||..||.|||:|.
Worm   380 EKKKIRRQNRKEVLKEKTEKIRLGLEKAPEPKVKISNLMRVLGNEAIQDPTKMEAQVRKQMAERL 444

  Fly   429 KAHEDANNARKLTSEQKSEKKQRKLREDTSCGVHVSVYRIRDLQDNQSKKFKVETNAKQLQMTGS 493
            |.||..|..||||.:||..||.:||.||||..|:|||||::.|. :.|||||||||||||||:|:
Worm   445 KKHETLNAERKLTEDQKRAKKTKKLSEDTSTAVNVSVYRVKSLA-HPSKKFKVETNAKQLQMSGA 508

  Fly   494 VVLFRDCCVVVVEGGPKQQKKYRRLMLTRIKWEED--NAKGNDGQDVP---NSCVLVWEGTSQRR 553
            :::.:...|:||||||||||.|:.||:.||||.::  ..|.:..:|.|   |.|.::|||..:||
Worm   509 IMMHKAQNVIVVEGGPKQQKFYKNLMINRIKWSDEIIGQKKDAEKDAPGERNLCEMIWEGQVKRR 573

  Fly   554 HFGEIKFKIFPMEKMAREFFQKHQVEHYWDLAYSGAVLEASTD 596
            :|.:.......:||.|||||:||.|..||||.||..||....|
Worm   574 NFRDFTVHTATLEKQAREFFEKHGVAQYWDLCYSTTVLLEGQD 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prp3	NP_649156.1	PRP3	229..441	CDD:285741	111/215 (52%)
Prp3	NP_649156.1	DUF1115	466..585	CDD:284060	61/123 (50%)
prp-3	NP_499300.1	PRP3	243..457	CDD:285741	111/215 (52%)
prp-3	NP_499300.1	DUF1115	482..605	CDD:284060	61/123 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166674
Domainoid	1	1.000	217	1.000	Domainoid score	I1552
eggNOG	1	0.900	-	-		E1_KOG2769
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3447
Inparanoid	1	1.050	373	1.000	Inparanoid score	I1217
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1322299at2759
OrthoFinder	1	1.000	-	-		FOG0004423
OrthoInspector	1	1.000	-	-		oto19708
orthoMCL	1	0.900	-	-		OOG6_102616
Panther	1	1.100	-	-	LDO	PTHR14212
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2239
SonicParanoid	1	1.000	-	-		X3705
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830