DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(Tpl) and ELL

DIOPT Version :9

Sequence 1:	NP_001163477.1	Gene:	Su(Tpl) / 40171	FlyBaseID:	FBgn0014037	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_006523.1	Gene:	ELL / 8178	HGNCID:	23114	Length:	621	Species:	Homo sapiens

Alignment Length:	965	Identity:	208/965 - (21%)
Similarity:	327/965 - (33%)	Gaps:	396/965 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NYGMSQSHRYTDDSKEYII-VKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTGVIQFPRP 82
            :||:| ..|.:|.||..:. |||||||.||.|.|:...::..|:|    .|:|.|:.|.|..|:|
Human     9 SYGLS-CGRVSDGSKVSVFHVKLTDSALRAFESYRARQDSVSLRP----SIRFQGSQGHISIPQP 68

  Fly    83 ATDANGIPNANGNGSDATGAGGGGGRKFGFTINNM-----EGTLECVQQQQRS-----LGVLGAV 137
            ...|.                   .|.|.|.::|:     :|:.:|:||...|     |..||::
Human    69 DCPAE-------------------ARTFSFYLSNIGRDNPQGSFDCIQQYVSSHGEVHLDCLGSI 114

  Fly   138 TLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKVKKPPSAIQSSASTASAFSS 202
            ..::.:.|.:|.|...|..||.|||..:|:....||.....:|:||:
Human   115 QDKITVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYLGKKVQ------------------ 161

  Fly   203 NSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGVGSSSSSSAFAS 267
                                                                            .
Human   162 ----------------------------------------------------------------F 162

  Fly   268 RSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRDSMTAGTSSATA 332
            |.|.|.                                                          |
Human   163 RKPAPG----------------------------------------------------------A 169

  Fly   333 SSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHLLALKAFKKPEL 397
            :..:.||.:.....|.|:...|.:|:      .|||   |.||:|..|:|::|||||:.::|.||
Human   170 TDAVPSRKRATPINLASAIRKSGASA------VSGG---SGVSQRPFRDRVLHLLALRPYRKAEL 225

  Fly   398 FARLKNEGIRDRERNQITNILMDISTMS--HNTYNLRRQMWNDVDENWPFFSEQEVQQLKRRKPQ 460
            ..||:.:|:...:::.:..:|..::.||  ..|..|:..|:.||.::||.:||.:.|.|||...:
Human   226 LLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQLLKRVLVR 290

  Fly   461 NLTPPMSSDAGSSTSGQSPTSTHTGS-PPPPSSNGGPGGVGSGAGGTSMKRTSLEYDETMFSTVQ 524
            .|..|.|                ||| ...|:::..||..|..|.....:....::.:.:.:
Human   291 KLCQPQS----------------TGSLLGDPAASSPPGERGRSASPPQKRLQPPDFIDPLAN--- 336

  Fly   525 PKKQRISHYKKDTPPSGTSYSSAGVSMSLGSSGSSSRSRYTPPQRQPGPLDDHSTTDLSYNVLDN 589
             ||.||||:.:...|:        |:..||.  .:.|....|   .|||
Human   337 -KKPRISHFTQRAQPA--------VNGKLGV--PNGREALLP---TPGP---------------- 371

  Fly   590 IVEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDKRNSTGSNSSSSSGYETQ 654

Human   372 ----------------------------------------------------------------- 371

  Fly   655 QDRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMPPQQSDYNSYNSNNAQHV 719
                    |.|::..| ||:..||:|.                    ||:..|..:..||:..|
Human   372 --------PASTDTLS-SSTHLPPRLE--------------------PPRAHDPLADVSNDLGH- 406

  Fly   720 ASNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSI-------QQQNQHQKQQVQ 777
                                     ||.:..:.:...|:...|..:       |....|
Human   407 -------------------------SGRDCEHGEAAAPAPTVRLGLPLLTDCAQPSRPH------ 440

  Fly   778 QKQAPSQQQQQQQQQYH---QQAKHPSPSQQL---AAAAHAYAHATAD--------------TDS 822
              .:||:.:.:::.:.|   ::|....|..||   |.|.||...|.||              |.:
Human   441 --GSPSRSKPKKKSKKHKDKERAAEDKPRAQLPDCAPATHATPGAPADTPGLNGTCSVSSVPTST 503

  Fly   823 SATPRYDFSQYVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGY 887
            |.||.| ..:|..|.:.|.|:.||.:|.::|.|||.|..|:|.:..||..|..:|   |:...|.
Human   504 SETPDY-LLKYAAISSSEQRQSYKNDFNAEYSEYRDLHARIERITRRFTQLDAQL---RQLSQGS 564

  Fly   888 GDYDHIKRQIVCEYERINNDRT-IGEDKERFDYLHAKLAHIKQLVMDYDKTLMSA 941
            .:|:..:.||:.||.:|....| ..::|.|.:|||:||||||:|:.:||:..:.|
Human   565 EEYETTRGQILQEYRKIKKTNTNYSQEKHRCEYLHSKLAHIKRLIAEYDQRQLQA 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(Tpl)	NP_001163477.1	ELL	16..460	CDD:287376	101/453 (22%)
Su(Tpl)	NP_001163477.1	Occludin_ELL	836..935	CDD:284669	38/99 (38%)
ELL	NP_006523.1	ELL	6..290	CDD:287376	101/453 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..417		40/289 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..504		17/80 (21%)
		Nuclear localization signal. /evidence=ECO:0000255	445..459		1/13 (8%)
		Occludin_ELL	516..613	CDD:284669	38/99 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146201
Domainoid	1	1.000	139	1.000	Domainoid score	I4799
eggNOG	1	0.900	-	-		E1_KOG4796
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3785
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170004at33208
OrthoFinder	1	1.000	-	-		FOG0002166
OrthoInspector	1	1.000	-	-		otm41749
orthoMCL	1	0.900	-	-		OOG6_100830
Panther	1	1.100	-	-	O	PTHR23288
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5695
SonicParanoid	1	1.000	-	-		X1874
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.880