Protein Alignment Su(Tpl) and ELL2

DIOPT Version :9

• Sequence 1: NP_001163477.1
• Gene: Su(Tpl) / 40171
• FlyBaseID: FBgn0014037
• Length: 1059
• Species: Drosophila melanogaster
• Sequence 2: NP_036213.2
• Gene: ELL2 / 22936
• HGNCID: 17064
• Length: 640
• Species: Homo sapiens
• Alignment Length: 951
• Identity: 193/951 - (20%)
• Similarity: 339/951 - (35%)
• Gaps: 354/951 - (37%)

  Fly    18 GNYGMSQSHRY-------TDDSKEYIIVKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTG 75
            |..|:.:..||       ..|:...:.||||::|.||:|.||...|....:|    .|||.|..|
Human     5 GTGGLREEQRYGLSCGRLGQDNITVLHVKLTETAIRALETYQSHKNLIPFRP----SIQFQGLHG 65

  Fly    76 VIQFPR--PATDANGIPNANGNGSDATGAGGGGGRKFGFTINNM-----EGTLECVQQQQRSLGV 133
            :::.|:  |..:.:                     .|.|.::|:     :|:.:|:||...|.|.
Human    66 LVKIPKNDPLNEVH---------------------NFNFYLSNVGKDNPQGSFDCIQQTFSSSGA 109

  Fly   134 -----LGAVTLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKV--KKPPSAIQ 191
                 ||.:..::.:.|..|.|..||.:|..|||..:::..:.|||....:|::|  :|.|.|:
Human   110 SQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAV- 173

  Fly   192 SSASTASAFSSNSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGV 256
                                                                             
Human   174 ----------------------------------------------------------------- 173

  Fly   257 GSSSSSSAFASRSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRD 321
                                                                             
Human   174 ----------------------------------------------------------------- 173

  Fly   322 SMTAGTSSATASSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHL 386
                       |..:..|.:       |:..|.:::.|..:|.|:       :|:|..|:|:|||
Human   174 -----------SDTVPERKR-------STPMNPANTIRKTHSSST-------ISQRPYRDRVIHL 213

  Fly   387 LALKAFKKPELFARLKNEGIRDRERNQITNILMDISTMSHN--TYNLRRQMWNDVDENWPFFSEQ 449
            |||||:|||||.|||:.:|:..:::|.:..||..::.::..  :|.|:..::.::..:||.:||.
Human   214 LALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEI 278

  Fly   450 EVQQLKRRKPQNLTPPMSSDAGSSTSGQSPTSTHTGSPPPPSSNGGPGGVGSGAGGTSMKRTSLE 514
            :.:.|:....:.|.|  |.:|..::..:||..:...:...|                 .||.
Human   279 DRRSLESVLSRKLNP--SQNAAGTSRSESPVCSSRDAVSSP-----------------QKRL--- 321

  Fly   515 YDETMFSTVQPKKQRISHYKKDTPPSGTSY-------SSAGVSMSLGSSGSSSRSRYTPPQRQPG 572
            .|......:..||.||||.....||:...:       |:||:.:...::...     |||
Human   322 LDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIP-----TPP----- 376

  Fly   573 PLDDHSTTDLSYNVLDNIVEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDK 637
            ||..      :|..:.:..:.::|.:             .|.|:...||:..|
Human   377 PLPS------TYLPISHPPQIVNSNS-------------NSPSTPEGRGTQDL------------ 410

  Fly   638 RNSTGSNSSSSSGYETQQDRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMP 702
              ...|.|.:.|.||.|||:..|.|         |..|.||                |:...:.|
Human   411 --PVDSFSQNDSIYEDQQDKYTSRT---------SLETLPP----------------GSVLLKCP 448

  Fly   703 PQQSDYNSYNSNNAQHVASNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSIQQ 767
            ....:.:|.:.       ..|||:                                |.......|
Human   449 KPMEENHSMSH-------KKSKKK--------------------------------SKKHKEKDQ 474

  Fly   768 QNQHQKQQVQQKQAPSQQQQQQQQQYHQQAKHPSPSQQLAAAAHAYAHATADTDSSATPRYDF-S 831
            ..:|..:.:::|     ::..::::...:..:.||:    ::.......||..:.||....|: .
Human   475 IKKHDIETIEEK-----EEDLKREEEIAKLNNSSPN----SSGGVKEDCTASMEPSAIELPDYLI 530

  Fly   832 QYVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGYGDYDHIKRQ 896
            :|:.|.:.|.|:.||.:|.::|||||.|..|:|.|..||..|..:   .:|...|..:|.::..:
Human   531 KYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQ---RKRLSPGSKEYQNVHEE 592

  Fly   897 IVCEYERI-NNDRTIGEDKERFDYLHAKLAHIKQLVMDYDK 936
            ::.||::| .:.....|:|.|.:|||.||||||:|:.::|:
Human   593 VLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQ 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(Tpl)	NP_001163477.1	ELL	16..460	CDD:287376	90/464 (19%)
		Occludin_ELL	836..935	CDD:284669	37/99 (37%)
ELL2	NP_036213.2	ELL	11..289	CDD:287376	88/458 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	172..202		8/185 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..320		7/48 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..490		41/258 (16%)
		PLRV_ORF5	<384..616	CDD:279954	65/334 (19%)
		Occludin_ELL	535..632	CDD:284669	37/99 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146203
Domainoid	1	1.000	139	1.000	Domainoid score	I4799
eggNOG	1	0.900	-	-		E1_KOG4796
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3785
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170004at33208
OrthoFinder	1	1.000	-	-		FOG0002166
OrthoInspector	1	1.000	-	-		otm41749
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23288
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5695
SonicParanoid	1	1.000	-	-		X1874
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.980