DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(Tpl) and Ell2

DIOPT Version :9

Sequence 1:	NP_001163477.1	Gene:	Su(Tpl) / 40171	FlyBaseID:	FBgn0014037	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_620403.2	Gene:	Ell2 / 192657	MGIID:	2183438	Length:	639	Species:	Mus musculus

Alignment Length:	944	Identity:	203/944 - (21%)
Similarity:	334/944 - (35%)	Gaps:	341/944 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GNYGMSQSHRY-------TDDSKEYIIVKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTG 75
            |..|:.:..||       ..|:...:.||||::|.||:|.||...|....:|    .|||.|..|
Mouse     5 GAAGLREEQRYGLACGRLGQDNITVLHVKLTETAIRALETYQSHKNLIPFRP----SIQFQGLQG 65

  Fly    76 VIQFPRPATDA-NGIPNANGNGSDATGAGGGGGRKFGFTINNMEGTLECVQQQQRSLGV-----L 134
            :::.|:  .|. |.:.|.|...|:.       ||      :|.:|:.:|:||...|.|.     |
Mouse    66 LMKIPK--NDPFNEVQNFNFYLSNV-------GR------DNPQGSFDCIQQTLSSSGASQLNCL 115

  Fly   135 GAVTLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKV--KKPPSAIQSSASTA 197
            |.:..::.:.|..|.|..||.:|..|||..:::..:.|||....:|::|  :|.|.||
Mouse   116 GFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAI------- 173

  Fly   198 SAFSSNSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGVGSSSSS 262
                                                     |:....:..|:|.|.
Mouse   174 -----------------------------------------SDTVPERKRSTPMNP--------- 188

  Fly   263 SAFASRSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRDSMTAGT 327
                                                     ||.|
Mouse   189 -----------------------------------------ANTI-------------------- 192

  Fly   328 SSATASSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHLLALKAF 392
                        .||.||                          :.||:|..|:|:||||||||:
Mouse   193 ------------RKMHSG--------------------------NSVSQRPYRDRVIHLLALKAY 219

  Fly   393 KKPELFARLKNEGIRDRERNQITNILMDISTMSHN--TYNLRRQMWNDVDENWPFFSEQEVQQLK 455
            |||||.|||:.:|:..:::|.:..||..::.::..  :|.|:..::.::..:||.:||.:.|.|.
Mouse   220 KKPELLARLQKDGVNQKDKNSLGAILQQVANLNPKDLSYTLKDYVFKELQRDWPGYSETDRQTLD 284

  Fly   456 RRKPQNLTPPMSSDAGSSTSGQSPTSTHTGSPPPPSSNGGPGGVGSGAGGTSMKRTSLEYDETMF 520
            ....:.|.|  |.:|.:|.| :||..:                 ...|..:..||   ..|....
Mouse   285 LVLSRKLNP--SQNASTSRS-ESPLCS-----------------SKDAASSPQKR---PLDSDFI 326

  Fly   521 STVQPKKQRISHYKKDTPPSGTSYSSAGVSMSLGSSGSSSRSRYTPPQRQPGPLDDHSTTDLSYN 585
            ..:..||.||||.....||:...|        |..:...|.:...||.
Mouse   327 DPLMNKKARISHLTNRVPPTLNGY--------LNPTSEKSCAGLLPPP----------------- 366

  Fly   586 VLDNIVEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDKRNSTGSNSSSSSG 650
                     ::.|..|...:.....|.||.......:|:...|..|...:|.  ...|.|.:.|.
Mouse   367 ---------AAAAIPTLSPLPSTHLPVSNPPQTVNSNSNSPSTPEGLGTQDL--PVDSFSQNGSI 420

  Fly   651 YETQQDRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMPPQQSDYNSYNSNN 715
            :|.||::..|.|.:         .|.||..|....|               .|.:.::
Mouse   421 FEDQQEKYTSRTCL---------ETLPPSSALLKCP---------------KPMEEEH------- 454

  Fly   716 AQHVASNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSIQQQNQHQKQQVQQKQ 780
                                                     |.|:.:|..:.:...:|.|:::..
Mouse   455 -----------------------------------------PVSHKKSKKKSKKHKEKDQIKKLD 478

  Fly   781 APSQQQQQQQQQYHQQAK----HPSPSQQLAAAAHAYAHATADTDSSAT---PRYDFSQYVPIQT 838
            ..:.:::::..|..:.||    .|:|::.:...      .||..:.|:.   |.| ..:|:.|.:
Mouse   479 IETMEEKEEDLQREETAKLSNASPNPNEGVKEG------CTASMEPSSALELPDY-LIKYIAIVS 536

  Fly   839 LEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGYGDYDHIKRQIVCEYER 903
            .|.|:.||.:|.::|||||.|..|:|.|..||..|..:   .:|...|..:|.::..:::.||::
Mouse   537 YEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQ---RKRLSPGSKEYQNVHEEVLQEYQK 598

  Fly   904 I-NNDRTIGEDKERFDYLHAKLAHIKQLVMDYDK 936
            | .:.....|:|.|.:|||.||||||:|:.::|:
Mouse   599 IKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQ 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(Tpl)	NP_001163477.1	ELL	16..460	CDD:287376	101/458 (22%)
Su(Tpl)	NP_001163477.1	Occludin_ELL	836..935	CDD:284669	37/99 (37%)
Ell2	NP_620403.2	ELL	11..289	CDD:287376	99/452 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..203		11/135 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..326		12/57 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..416		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..513		14/142 (10%)
		Occludin_ELL	534..631	CDD:284669	37/99 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836304
Domainoid	1	1.000	140	1.000	Domainoid score	I4746
eggNOG	1	0.900	-	-		E1_KOG4796
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4252
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170004at33208
OrthoFinder	1	1.000	-	-		FOG0002166
OrthoInspector	1	1.000	-	-		otm43800
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23288
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5695
SonicParanoid	1	1.000	-	-		X1874
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.980