DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(Tpl) and MARVELD2

DIOPT Version :9

Sequence 1:	NP_001163477.1	Gene:	Su(Tpl) / 40171	FlyBaseID:	FBgn0014037	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_001033692.2	Gene:	MARVELD2 / 153562	HGNCID:	26401	Length:	558	Species:	Homo sapiens

Alignment Length:	192	Identity:	51/192 - (26%)
Similarity:	87/192 - (45%)	Gaps:	27/192 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 QQVPPPSSNSRSSIQQQ----NQHQKQQVQQKQAPSQQQQQQQQQYHQQAKH-PSPSQQLAAAAH 811
            |::..||.:|:..:.:.    ::.:..:|..|:..:.:.:.:....|....| |.|
Human   381 QEINEPSLSSKRKMCEMATSGDRQRDSEVNFKELRTAKMKPELLSGHIPPGHIPKP--------- 436

  Fly   812 AYAHATADTDSSATPRYDFSQYVPIQTLEVRRRYKTEFESDYDEYRKLLTRVEDVRNRFQDLSER 876
                       ...|.| .::|..|||.:.|.|||..|:..:.||::|...|:.|..:|.:|...
Human   437 -----------IVMPDY-VAKYPVIQTDDERERYKAVFQDQFSEYKELSAEVQAVLRKFDELDAV 489

  Fly   877 LESARRCDNGYGDYDHIKRQIVCEYERINNDRTIGEDKERFDYLHAKLAHIKQLVMDYDKTL 938
            :...........:::.|.| |..|:::..||.|..|.|||.|||..||:||||.:.:|||.:
Human   490 MSRLPHHSESRQEHERISR-IHEEFKKKKNDPTFLEKKERCDYLKNKLSHIKQRIQEYDKVM 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(Tpl)	NP_001163477.1	ELL	16..460	CDD:287376
Su(Tpl)	NP_001163477.1	Occludin_ELL	836..935	CDD:284669	35/98 (36%)
MARVELD2	NP_001033692.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..145
		MARVEL	185..361	CDD:279608
		Occludin_ELL	449..547	CDD:284669	35/98 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146204
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4796
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170004at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23288
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940