Protein Alignment Mi-2 and Smarca5

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_444354.2
• Gene: Smarca5 / 93762
• MGIID: 1935129
• Length: 1051
• Species: Mus musculus
• Alignment Length: 1107
• Identity: 327/1107 - (29%)
• Similarity: 495/1107 - (44%)
• Gaps: 242/1107 - (21%)

  Fly   634 KWRELPYDKSTWEEE-----GDDIQGLRQAIDYYQDLRAVCTSETTQSRSK------KSKKGRKS 687
            |.:|:.....|:||:     .:..:.|.:..:.:.........:|..|..|      :.||..|.
Mouse    68 KQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKMKPGRPRVKKDEKQ 132

  Fly   688 KL---------KVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLR 743
            .|         :.|.:||..:.    ......|::..::||.|::::..  :|..||:.|:|||.
Mouse   133 NLLSVGDYRHRRTEQEEDEELL----TESSKATNVCTRFEDSPSYVKWG--KLRDYQVRGLNWLI 191

  Fly   744 YSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYC 808
            ..:..||:.|||||||||||:||::.|..:....:..||.:|.||.|||.||..||:.|.|....
Mouse   192 SLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKKWVPTLRS 256

  Fly   809 ITYIGDKDSRAV-IRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAV 872
            :..||||:.||. :|:..|..|                  ::|.:||||::..:.:.....:|..
Mouse   257 VCLIGDKEQRAAFVRDVLLPGE------------------WDVCVTSYEMLIKEKSVFKKFNWRY 303

  Fly   873 LVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEF 937
            ||:|||||:|:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|
Mouse   304 LVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWF 368

  Fly   938 AD---VSKEEQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEA 999
            ..   :..::.|:|||.:|.|.:|||:|.||.|::|.|.|..:.|.||.||:::|..||.|:.:.
Mouse   369 DTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDI 433

  Fly  1000 LNSKSGGGSCSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEIN-SLTKAAGKLVLLSKMLK 1063
            |||........|:||:|.|:|||||||||..|      ..|..|..: .|...:||:|:|.|:|.
Mouse   434 LNSAGKMDKMRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDMHLVTNSGKMVVLDKLLP 492

  Fly  1064 QLKAQNHRVLIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLS 1128
            :||.|..|||||||||::||||||:.....|:|.|:||......||::|:.:|.|.:.:|||:||
Mouse   493 KLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLS 557

  Fly  1129 TRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKR 1193
            ||||||||||||||.||:|||||||..|:||..|||||||...|.::||:|.|:||||:.:.|:.
Mouse   558 TRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEM 622

  Fly  1194 KMMLTHLVVRPG-MGGKGAN-FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRG 1256
            |:.|..:|::.| :..:..| ..|.|:..::|.|...:|...:.|    ..|:.:..:|:|.
Mouse   623 KLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESE----ITDEDIDGILERG--- 680

  Fly  1257 IEEKESWANEYLSSFKVAS------------YATKEEEEEEETEII----------KQDAENSDP 1299
             .:|.:..||.||....:|            |..:.|:..|:.:|.          ::.|..:..
Mouse   681 -AKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKANYAVD 744

  Fly  1300 AYWVKLLRHHYEQHQEDVGRSLGKGKRVRKQVNYTDGGVVAA---DTTRDDSNWQDNGSEYNSEY 1361
            ||:.:.||....:        ..|..|..||.|..|......   :....:..:......|....
Mouse   745 AYFREALRVSEPK--------APKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPR 801

  Fly  1362 SAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVL---------GF---NA 1414
            |.           |..|.|:.:.:.:|:..:..||         |.|.|         ||   |.
Mouse   802 SP-----------DLPNAAQAQKEEQLKIDEAEPL---------NDEELEEKEKLLTQGFTNWNK 846

  Fly  1415 RQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVP 1479
            |....|:.|            |.:|                           |.|:.|..|..|
Mouse   847 RDFNQFIKA------------NEKW---------------------------GRDDIENIAREV- 871

  Fly  1480 REGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAP----- 1539
             ||.:.:.|:....|......::|:.|.|.......|..::....::.||...:...:||
Mouse   872 -EGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLR 935

  Fly  1540 -PTGGNVDKSATTSNSVTPATSAAPSPAPASEKGEDK-----------DKDSEKE---------- 1582
             ..|.|..|:.|                    :.||:           ||::..:
Mouse   936 ISYGTNKGKNYT--------------------EEEDRFLICMLHKLGFDKENVYDELRQCIRNSP 980

  Fly  1583 --------KDKTSAEKSE--------VKQEQEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTE 1631
                    |.:|:.|...        :::|....|:|:..:.|:..|        |||..:.|.:
Mouse   981 QFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGP--------KPSTQKRKMD 1037

  Fly  1632 VA 1633
            .|
Mouse  1038 GA 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	6/34 (18%)
		PLN03142	720..>1234	CDD:215601	226/520 (43%)
		DUF1087	<1292..1334	CDD:461922	10/41 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	27/148 (18%)
		CHDCT2	1757..1902	CDD:462358
Smarca5	NP_444354.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..81		3/12 (25%)
		PLN03142	68..1011	CDD:215601	317/1069 (30%)
		DEAH box	307..310		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1014..1051		9/34 (26%)