Protein Alignment Mi-2 and Smarca1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_001277637.1
• Gene: Smarca1 / 93761
• MGIID: 1935127
• Length: 1062
• Species: Mus musculus
• Alignment Length: 1220
• Identity: 341/1220 - (27%)
• Similarity: 517/1220 - (42%)
• Gaps: 305/1220 - (25%)

  Fly   558 KYDMEEPPKFEESLDEADTRYKRIQRHKDKVGMKAND-DAEVLEERFYKNGVKPEWLIVQRVINH 621
            |.:.|..|::||.:.....:..|.:|.  :..:|..: .|..::....|:...|        :|.
Mouse    73 KSEKEMDPEYEEKMVNMPLKADRAKRF--EFLLKQTELFAHFIQPSAQKSPTSP--------LNM 127

  Fly   622 RTARDGSTMYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRK 686
            :.||             |..|.      ||.|.|....||                       |.
Mouse   128 KLAR-------------PRVKK------DDKQSLISVGDY-----------------------RH 150

  Fly   687 SKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGID 751
            .:.:.|:||:      .....:.|:::..::|..|::::|.  .|..|||.|:|||...:..|::
Mouse   151 RRTEQEEDEE------LLSESRKTSNVCVRFEVSPSYVKGG--PLRDYQIRGLNWLISLYENGVN 207

  Fly   752 TILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKD 816
            .|||||||||||:||:..|..|....:..||.:|.||.|||.||..||:.|.|....|.::||||
Mouse   208 GILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKD 272

  Fly   817 SRAVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRL 881
            .||....:|:...|                 ::|.:||||::..:.:......|..||:|||||:
Mouse   273 VRAAFIRDEMMPGE-----------------WDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRI 320

  Fly   882 KSNQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFAD---VSKE 943
            |:.:||...|:..:....:||||||||||||.||:.|||||..|.||....|...|..   :..:
Mouse   321 KNEKSKLSEIVREFKSTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQ 385

  Fly   944 EQVKRLHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGS 1008
            :.|:|||.:|.|.:|||:||||.|::|.|.|..:.:.||.||:::|..||.|:.:.|||......
Mouse   386 KLVERLHAVLKPFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDK 450

  Fly  1009 CSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINS-LTKAAGKLVLLSKMLKQLKAQNHRV 1072
            ..|:||:|.|:|||||||||..|      ..|..|..:. :...:||:|.|.|:|.::|.|..||
Mouse   451 MRLLNILMQLRKCCNHPYLFDGA------EPGPPYTTDEHIVGNSGKMVALDKLLARIKEQGSRV 509

  Fly  1073 LIFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGIN 1137
            |||||||::||||||:.....|:|.|:||......|:||||.||||.:.:|:|:|||||||||||
Mouse   510 LIFSQMTRLLDILEDYCMWRGYEYSRLDGQTPHEEREEAIDAFNAPNSSKFIFMLSTRAGGLGIN 574

  Fly  1138 LATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV 1202
            ||:||.||:|||||||..|:||..|||||||...|.::|.:|.|:||||:.:.|:.|:.|..:|:
Mouse   575 LASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLITDNTVEERIVERAEIKLRLDSIVI 639

  Fly  1203 RPG--MGGKGANFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWAN 1265
            :.|  :..:.....|:|:..::|.|...:|...:.|    ..|:.:..:|:|.    |:|.:..|
Mouse   640 QQGRLIDQQSNKLAKEEMLQMIRHGATHVFACKESE----LTDEDIVTILERG----EKKTAEMN 696

  Fly  1266 EYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDVGRSLG------KG 1324
            |.:           ::..|......:.|.|.|       |.:...|.::|.  :.||      ..
Mouse   697 ERM-----------QKMGESSLRNFRMDLEQS-------LYKFEGEDYREK--QKLGTVEWIEPP 741

  Fly  1325 KRVRKQVNY------------TDGGVVAADTTRDDSNWQD------------------------- 1352
            ||.|| .||            ::..:..|.......|.||
Mouse   742 KRERK-ANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGY 805

  Fly  1353 ---NGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNA 1414
               ...|..:...|..:|....|      |||....:..|.:|     .||.:...|.....||
Mouse   806 KVPRNPEIPNPAIAQREEQKKID------GAEPLTPQETEEKD-----KLLTQGFTNWTKRDFN- 858

  Fly  1415 RQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFADGVP 1479
                .|:.|..:||....|.     :.|::.|||......|.::|.....|
Mouse   859 ----QFIKANEKYGRDDIDN-----IAREVEGKSPEEVMEYSAVFWERCNE-------------- 900

  Fly  1480 REGLSRQHVLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCEPVRSALKQDVAALEAPPTGGN 1544
                                  :|:.|.|.......|..::....::.||...:|..:||.....
Mouse   901 ----------------------LQDIEKIMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLR 943

  Fly  1545 VDKSATTSNSVTPATSAAPSPAPASEKGEDKDKDSEKEKD--------KTSAEKSEVKQE----- 1596
            :                        :.|..|.|:..:|:|        |...::..|.:|
Mouse   944 I------------------------QYGTSKGKNYTEEEDRFLICMLHKMGFDRENVYEELRQCV 984

  Fly  1597 QEAEEDKKPGDVKQENPVEEAAGDTKPSDAEVKTEVAKTEPKEETKDPEVKEEPKTEEKEKEKVD 1661
            :.|.:.:....:|....:|        ......|.::..|          ||..:.||:|:
Mouse   985 RNAPQFRFDWFIKSRTAME--------FQRRCNTLISLIE----------KENMEIEERER---- 1027

  Fly  1662 DKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATG 1711
                                    .|.:|.:..:|..||..|.:.:.::|
Mouse  1028 ------------------------AEKKKRATKTPMSQKRKAESATESSG 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	12/53 (23%)
		PLN03142	720..>1234	CDD:215601	226/519 (44%)
		DUF1087	<1292..1334	CDD:461922	14/59 (24%)
		CHDII_SANT-like	1380..1517	CDD:461920	24/136 (18%)
		CHDCT2	1757..1902	CDD:462358
Smarca1	NP_001277637.1	PLN03142	2..1061	CDD:215601	341/1220 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..61
		DEAH box	315..318		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	819..840		6/26 (23%)