DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mi-2 and CHD1

DIOPT Version :9

Sequence 1:	NP_001014591.1	Gene:	Mi-2 / 40170	FlyBaseID:	FBgn0262519	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	NP_011091.1	Gene:	CHD1 / 856911	SGDID:	S000000966	Length:	1468	Species:	Saccharomyces cerevisiae

Alignment Length:	1715	Identity:	467/1715 - (27%)
Similarity:	738/1715 - (43%)	Gaps:	427/1715 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 ARSVTGDEPEEP------RSSRSSRNEKPDDIYEEAVEEEEEEEEEEKKPRRKRSGRGKKGRRPS 267
            |:.::.:..:.|      ||.|::.:::  :.:.::  ::|::|:..|:.||||
Yeast     3 AKDISTEVLQNPELYGLRRSHRAAAHQQ--NYFNDS--DDEDDEDNIKQSRRKR----------- 52

  Fly   268 GKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDSADEKEAPVSSKADNSAPA 332
              :.|::         |..||.:|..|  |.||.        :.:|..|.:|
Yeast    53 --MTTIE---------DDEDEFEDEEG--EEDSG--------EDEDEEDFEE------------- 83

  Fly   333 AQDDGSGAPVVRKKAKTKIGNKFKKKNKLK--------------------KTKNFPEGEDGEHEH 377
             .||..|:|:.:.::|.|...|.|.|:|.|                    ||.|:         :
Yeast    84 -DDDYYGSPIKQNRSKPKSRTKSKSKSKPKSQSEKQSTVKIPTRFSNRQNKTVNY---------N 138

  Fly   378 QDYCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCR 442
            .||                                           :|....|.|||...:|  .
Yeast   139 IDY-------------------------------------------SDDDLLESEDDYGSEE--A 158

  Fly   443 VCKDGGELLCCDSCPSAYH--TFCLNPPLDTIPDGDWRCPRCSCPPLTGKA-EKIITWRWAQRSN 504
            :.::.......:..|..:|  ...:|..|.|..:             .||. ||.:
Yeast   159 LSEENVHEASANPQPEDFHGIDIVINHRLKTSLE-------------EGKVLEKTV--------- 201

  Fly   505 DDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQL-DVHHPLMIRSFQRKYDMEEPPKFE 568
               |..:...:|     .|:.|||.:.|:.|..|.....: .|.....:.::.:::.:|:.   :
Yeast   202 ---PDLNNCKEN-----YEFLIKWTDESHLHNTWETYESIGQVRGLKRLDNYCKQFIIEDQ---Q 255

  Fly   569 ESLDEADTRYKRIQRHKDKVGMKANDDAEVLE-ERFYKNGVKPEWLIVQRVINHRTA--RDGST- 629
            ..||...|.                :|.|::: ||..:.....|:.:.:|:|:.:.|  .||::
Yeast   256 VRLDPYVTA----------------EDIEIMDMERERRLDEFEEFHVPERIIDSQRASLEDGTSQ 304

  Fly   630 -MYLVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQ-----SRSKKSKKGRKSK 688
             .||||||.|.||::|||...|.::...:.:.::|:      .|.::     |.:..|::.|..|
Yeast   305 LQYLVKWRRLNYDEATWENATDIVKLAPEQVKHFQN------RENSKILPQYSSNYTSQRPRFEK 363

  Fly   689 LKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTI 753
            |.|                            ||.|::|.  :|..:|:.||||:.:.|.:|.:.|
Yeast   364 LSV----------------------------QPPFIKGG--ELRDFQLTGINWMAFLWSKGDNGI 398

  Fly   754 LADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSR 818
            ||||||||||:|||.|:..|.......||.::.|||||:..|...||.||||..||.|:|::.||
Yeast   399 LADEMGLGKTVQTVAFISWLIFARRQNGPHIIVVPLSTMPAWLDTFEKWAPDLNCICYMGNQKSR 463

  Fly   819 AVIRENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKS 883
            ..|||.|. :.....:|.|.       .|||||||:||.|..|.|.||||.|..:.||||||||:
Yeast   464 DTIREYEF-YTNPRAKGKKT-------MKFNVLLTTYEYILKDRAELGSIKWQFMAVDEAHRLKN 520

  Fly   884 NQSKFFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKR 948
            .:|..:..|||:.:|.::|:||||||||::||..|:|||...:|...|....|..|..:||.:..
Yeast   521 AESSLYESLNSFKVANRMLITGTPLQNNIKELAALVNFLMPGRFTIDQEIDFENQDEEQEEYIHD 585

  Fly   949 LHEMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSCSLIN 1013
            ||..:.|.:|||||.||.|::|||:|.|:|||||.:|.::||.||||||.||.:.:.||..||:|
Yeast   586 LHRRIQPFILRRLKKDVEKSLPSKTERILRVELSDVQTEYYKNILTKNYSALTAGAKGGHFSLLN 650

  Fly  1014 IMMDLKKCCNHPYLFPSAAEEATTAAG-GLYE----INSLTKAAGKLVLLSKMLKQLKAQNHRVL 1073
            ||.:|||..||||||.:|.|......| |...    :..|..::||:|||.::|.:||...||||
Yeast   651 IMNELKKASNHPYLFDNAEERVLQKFGDGKMTRENVLRGLIMSSGKMVLLDQLLTRLKKDGHRVL 715

  Fly  1074 IFSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINL 1138
            |||||.:|||||.|:|..:...::|:||.:....|:.:||.||:|.:..||||||||||||||||
Yeast   716 IFSQMVRMLDILGDYLSIKGINFQRLDGTVPSAQRRISIDHFNSPDSNDFVFLLSTRAGGLGINL 780

  Fly  1139 ATADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVR 1203
            .|||||:|:||||||..|:||.:|||||||.|.||:||.|::::|||.|.:.|::||:|.:.::.
Yeast   781 MTADTVVIFDSDWNPQADLQAMARAHRIGQKNHVMVYRLVSKDTVEEEVLERARKKMILEYAIIS 845

  Fly  1204 PGMGGKGANFTKQ------ELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDR-----TNRGI 1257
            .|: ..|..:||:      ||..||:||..::|...|.::.:  :|..:.::|:.     |...:
Yeast   846 LGV-TDGNKYTKKNEPNAGELSAILKFGAGNMFTATDNQKKL--EDLNLDDVLNHAEDHVTTPDL 907

  Fly  1258 EEKESWANEYLSSFKVASYATKEE-----EEEEETEIIKQDAENSDPAYWVKLLRHHYEQHQEDV 1317
            .|......|:|..|:|..|....:     .|||..::..::.:..|..|        .::..|.:
Yeast   908 GESHLGGEEFLKQFEVTDYKADIDWDDIIPEEELKKLQDEEQKRKDEEY--------VKEQLEMM 964

  Fly  1318 GRSLGKGKRVRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDG-GDDDFDDQNGAE 1381
            .|.....|:::..||   |...||::..||    |:.|..:...:..:|.|. |:.:.
Yeast   965 NRRDNALKKIKNSVN---GDGTAANSDSDD----DSTSRSSRRRARANDMDSIGESEV------- 1015

  Fly  1382 RKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQDAFNSQWLVRDLRG 1446
                        |.|...:.:.|...|:|..........:.:..:||....:...:   .:|...
Yeast  1016 ------------RALYKAILKFGNLKEILDELIADGTLPVKSFEKYGETYDEMMEA---AKDCVH 1065

  Fly  1447 KSERNFKAYVSLFMRHLCEPGADNAETFADGVPREGLSRQHVLTRI---------------GVMS 1496
            :.|:|.|..:....:|..   |..|:..:..:..|...:.:.|||:               ||.|
Yeast  1066 EEEKNRKEILEKLEKHAT---AYRAKLKSGEIKAENQPKDNPLTRLSLKKREKKAVLFNFKGVKS 1127

  Fly  1497 L----IRKKVQEFEH----INGYY-------SMPELILKPCEPVRS--ALKQDVAAL-------- 1536
            |    :..:|::.::    ||..|       |:.....||.:...|  ..::|...|
Yeast  1128 LNAESLLSRVEDLKYLKNLINSNYKDDPLKFSLGNNTPKPVQNWSSNWTKEEDEKLLIGVFKYGY 1192

  Fly  1537 ------EAPPTGGNVDKSATTS--NSVT--PATSAAPSPAPASEKGEDKDKDSEKEKD------- 1584
                  ...|..|..||.....  |.|.  .|:|:..:|.| |:||:.....|:|...
Yeast  1193 GSWTQIRDDPFLGITDKIFLNEVHNPVAKKSASSSDTTPTP-SKKGKGITGSSKKVPGAIHLGRR 1256

  Fly  1585 ------------KTSAEKSEVKQEQEAEEDKK----PGDVKQENPVEEAAGDTKPSDAEVKTEVA 1633
                        .|.:..:::       ..||    |...:|..|...:...|        .|:.
Yeast  1257 VDYLLSFLRGGLNTKSPSADI-------GSKKLPTGPSKKRQRKPANHSKSMT--------PEIT 1306

  Fly  1634 KTEPKEETKDPEVKEEPKTEEK--EKEKVDDKKPIPPTTVIDDDDDDVMIVKEDG--ELEKPSAS 1694
            .:||........:|..||....  ...::....|.||.        ...:.:::|  :...||:.
Yeast  1307 SSEPANGPPSKRMKALPKGPAALINNTRLSPNSPTPPL--------KSKVSRDNGTRQSSNPSSG 1363

  Fly  1695 S----------PKDQKAVAAATSAATGATGKGAEDSLEVLKRKFMFNIADGGFTELHTLWLNEE- 1748
            |          .:|.:...:|...:.....:|.:.    |.||....|..   |||.|:..:.|
Yeast  1364 SAHEKEYDSMDEEDCRHTMSAIRTSLKRLRRGGKS----LDRKEWAKILK---TELTTIGNHIES 1421

  Fly  1749 ------KAAVPGREYEIWHRRHDYW 1767
                  ||:.......:|....::|
Yeast  1422 QKGSSRKASPEKYRKHLWSYSANFW 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..190	CDD:285335
		PHD1_CHD_II	380..422	CDD:277006	1/41 (2%)
		PHD2_CHD_II	440..482	CDD:277007	5/43 (12%)
		CHROMO	490..558	CDD:237991	13/69 (19%)
		CHROMO	615..667	CDD:214605	19/55 (35%)
		SNF2_N	734..1028	CDD:278600	146/293 (50%)
		DEXDc	751..907	CDD:238005	75/155 (48%)
		Helicase_C	1053..1167	CDD:278689	68/113 (60%)
		DUF1087	<1292..1337	CDD:283996	7/44 (16%)
		DUF1086	1380..1517	CDD:283992	27/166 (16%)
		CHDCT2	1756..1927	CDD:285336	2/12 (17%)
CHD1	NP_011091.1	CD1_tandem_CHD1_yeast_like	175..247	CDD:349312	18/101 (18%)
		CD2_tandem_ScCHD1_like	283..341	CDD:349311	20/63 (32%)
		PLN03142	363..>961	CDD:215601	272/646 (42%)
		Cdh1_DBD_1	1010..1129	CDD:408024	22/143 (15%)
		SANT_TRF	1175..>1204	CDD:212558	3/28 (11%)
		DUF4208	1368..1460	CDD:404744	16/86 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46623
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910