Protein Alignment Mi-2 and MOT1

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_015243.1
• Gene: MOT1 / 856023
• SGDID: S000006003
• Length: 1867
• Species: Saccharomyces cerevisiae
• Alignment Length: 715
• Identity: 220/715 - (30%)
• Similarity: 323/715 - (45%)
• Gaps: 136/715 - (19%)

  Fly   660 DYYQDLRAVCTSETTQSRSK--------KSKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKK 716
            |..:|:|.:.|: |..|..|        ...||...:|....:.:|........|.|     .|.
Yeast  1203 DSNEDVRNLATT-TFASIIKLVPLEAGIADPKGLPEELVASRERERDFIQQMMDPSK-----AKP 1261

  Fly   717 YEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYS---LYKEGH 778
            :: .|..::.|   |..||.:|:|||.:.....:..||.|:||||||:||:..:.|   |.||.:
Yeast  1262 FK-LPIAIKAT---LRKYQQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRKEDY 1322

  Fly   779 CRG--------PFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRG 835
            .:.        |.|:..|.|...:||.||:.:||....:.|.|....|..:|. :||
Yeast  1323 EKTRSVESRALPSLIICPPSLTGHWENEFDQYAPFLKVVVYAGGPTVRLTLRP-QLS-------- 1378

  Fly   836 SKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYK 900
                       ..::::|||::...|.|.|...::...|:||.|.:|::|||..:.:...|..::
Yeast  1379 -----------DADIIVTSYDVARNDLAVLNKTEYNYCVLDEGHIIKNSQSKLAKAVKEITANHR 1432

  Fly   901 LLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFA----------DVSKEEQ-----VKRLH 950
            |:|||||:|||:.||:.|.:||........:.||..||          ..|||::     ::.||
Yeast  1433 LILTGTPIQNNVLELWSLFDFLMPGFLGTEKMFQERFAKPIAASRNSKTSSKEQEAGVLALEALH 1497

  Fly   951 EMLGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFY-------KFILTKNYEALNSKSGGGS 1008
            :.:.|.||||||.|||.::|.|.......||..:||:.|       |.::.|:.|  ||:...|.
Yeast  1498 KQVLPFMLRRLKEDVLSDLPPKIIQDYYCELGDLQKQLYMDFTKKQKNVVEKDIE--NSEIADGK 1560

  Fly  1009 CSLINIMMDLKKCCNHPYLFPSAAEEATTAAGGLYEINSLTKAAG----------KLVLLSKML- 1062
            ..:...:..::|.||||.|..|.....      |.::....|..|          ||..|..:|
Yeast  1561 QHIFQALQYMRKLCNHPALVLSPNHPQ------LAQVQDYLKQTGLDLHDIINAPKLSALRTLLF 1619

  Fly  1063 -----------KQLKAQN---------HRVLIFSQMTKMLDILEDFLEGEQY----KYERIDGGI 1103
                       |..:.||         ||.|||.|:..|||::|:.| .::|    .|.|:||.|
Yeast  1620 ECGIGEEDIDKKASQDQNFPIQNVISQHRALIFCQLKDMLDMVENDL-FKKYMPSVTYMRLDGSI 1683

  Fly  1104 TGTLRQEAIDRFNA-PGAQQFVFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIG 1167
            ....||:.:.:||. |...  ..||:|:.||||:||..|||||..:.||||.||:||..||||||
Yeast  1684 DPRDRQKVVRKFNEDPSID--CLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRIG 1746

  Fly  1168 QANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGANFTKQELDDILRFGTEDLFKE 1232
            |...|.:||.:|:.::||::..:.|.||.:...||.....|..:..|.|.|         |||..
Yeast  1747 QKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVVNQQNSGLASMDTHQLL---------DLFDP 1802

  Fly  1233 D-----DKEEAIHYDDKAVAELLDRTNR-GIEEKESWANEYLSSFKVASYATKEEEEEEETEIIK 1291
            |     |.||..:.|.:|...:.|..|. |:..|   |.|.|...|.....::.|||......||
Yeast  1803 DNVTSQDNEEKNNGDSQAAKGMEDIANETGLTGK---AKEALGELKELWDPSQYEEEYNLDTFIK 1864

  Fly  1292  1291
            Yeast  1865  1864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	1/3 (33%)
		PLN03142	720..>1234	CDD:215601	188/587 (32%)
		DUF1087	<1292..1334	CDD:461922	220/715 (31%)
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
MOT1	NP_015243.1	HEAT repeat	360..385	CDD:293787
		HEAT repeat	406..438	CDD:293787
		HEAT repeat	449..481	CDD:293787
		HEAT repeat	490..519	CDD:293787
		HEAT repeat	543..572	CDD:293787
		DUF3535	611..1063	CDD:463447
		HepA	<1258..1781	CDD:440319	180/562 (32%)