Protein Alignment Mi-2 and SNF2

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_014933.3
• Gene: SNF2 / 854465
• SGDID: S000005816
• Length: 1703
• Species: Saccharomyces cerevisiae
• Alignment Length: 1617
• Identity: 427/1617 - (26%)
• Similarity: 654/1617 - (40%)
• Gaps: 417/1617 - (25%)

  Fly   104 KRKEEKQAAKEKESASSG----MPSVEDVCSAFSVCNVEIEYSEE-------ELQSLTTYKAFMH 157
            |:::|.|..::::..|..    :|:..|.....:..:..|..|..       :|....|:....|
Yeast    49 KQRQELQMQRQQQGISGSQQNIVPNSSDQAELPNNASSHISASASPHLAPNMQLNGNETFSTSAH 113

  Fly   158 HVRPILQKENPKIAAPKLVMLVAAKWREFCESN------PHIQQEGGA----------AGSGGSA 206
            . .||:|.:.|                  ..||      |..|...|:          |.:|.:|
Yeast   114 Q-SPIMQTQMP------------------LNSNGGNNMLPQRQSSVGSLNATNFSPTPANNGENA 159

  Fly   207 G--------------------QARSV----TGDEPEEPRSSRSSRNEKPDDIYEEAVEEEEEEEE 247
            .                    |.||:    ..|....|.|..:|...:...:.:...:.::.::.
Yeast   160 AEKPDNSNHNNLNLNNSELQPQNRSLQEHNIQDSNVMPGSQINSPMPQQAQMQQAQFQAQQAQQA 224

  Fly   248 EEKKPRRKRSGRGKKGRR-PSG----------KVPTLKIKLLGKRKRDSSDEEQDASGASERDSD 301
            ::.:..::...|.::||| |..          |.....:|.|..||....:.:.....:.....|
Yeast   225 QQAQQAQQAQARLQQGRRLPMTMFTAEQSELLKAQITSLKCLVNRKPIPFEFQAVIQKSINHPPD 289

  Fly   302 L--------EFERMLQKSD---------------------------------------DSADEKE 319
            .        ||.|..|.:|                                       ||.||..
Yeast   290 FKRMLLSLSEFARRRQPTDQNNQSNLNGGNNTQQPGTNSHYNNTNTDNVSGLTRNAPLDSKDENF 354

  Fly   320 APVSSKADNSAPAAQDDG--------SGAPVVRKKAKTK----IGNKFK---KKNKLKKTKNFPE 369
            |.||....:|...|::..        ||.|:.:.::|.:    |.|..|   ..||....:|.|.
Yeast   355 ASVSPAGPSSVHNAKNGTLDKNSQTVSGTPITQTESKKEENETISNVAKTAPNSNKTHTEQNNPP 419

  Fly   370 GEDG-------EHEHQDYCEVCQQGGEIILCD--TCPRAYHL-VCLEPELDEPPEGKWSCPHCEA 424
            ....       :.::::..:|.......::.|  |.|...|. :..:..|......|::......
Yeast   420 KPQKPVPLNVLQDQYKEGIKVVDIDDPDMMVDSFTMPNISHSNIDYQTLLANSDHAKFTIEPGVL 484

  Fly   425 DGGAAEEEDDDEHQEFCRV--------CKDGGELLCCDSCPSA------YHTFCLN-PPLDTIPD 474
            ..|.......|.:|....:        |.|   .|..|.|..:      |..:.|. .||.....
Yeast   485 PVGIDTHTATDIYQTLIALNLDTTVNDCLD---KLLNDECTESTRENALYDYYALQLLPLQKAVR 546

  Fly   475 GDWRCPRCSCPPLTGKAEKIITWRWAQRSNDDGPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWV 539
            |                 .::.:.|.|.|.......:..||..|..|::..:.  |..|.:.|.:
Yeast   547 G-----------------HVLQFEWHQNSLLTNTHPNFLSKIRNINVQDALLT--NQLYKNHELL 592

  Fly   540 --------PEVQLDVHHPLMIRSFQRKYDMEEPP-KFEESLD------EADTRYKRIQRHKDKV- 588
                    ...:|...:...|..:.|:.|.:... ||...|.      |.|.:.:..::.|:::
Yeast   593 KLERKKTEAVARLKSMNKSAINQYNRRQDKKNKRLKFGHRLIATHTNLERDEQKRAEKKAKERLQ 657

  Fly   589 GMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTMYLVKWRELPYDKSTWEEEGDDIQ 653
            .:||||     ||.:.|...:.:...:..::....|...|....||      |:..:.:|..| .
Yeast   658 ALKAND-----EEAYIKLLDQTKDTRITHLLRQTNAFLDSLTRAVK------DQQKYTKEMID-S 710

  Fly   654 GLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVE---DDEDRPVKHYTPPPEKPTTDLKK 715
            .:::|.:...||..|                  .|:|.|   ||:|.....|.....:...|:||
Yeast   711 HIKEASEEVDDLSMV------------------PKMKDEEYDDDDDNSNVDYYNVAHRIKEDIKK 757

  Fly   716 KYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCR 780
                ||:.|  .|..|..|||:|:.|:...:...::.||||||||||||||::.|..||:..:.|
Yeast   758 ----QPSIL--VGGTLKDYQIKGLQWMVSLFNNHLNGILADEMGLGKTIQTISLLTYLYEMKNIR 816

  Fly   781 GPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIRENELSFEEGAIRGSKVSRLRTTQ 845
            ||:||.||||||.||..||..|||....|::.|.        .||...::..||..
Yeast   817 GPYLVIVPLSTLSNWSSEFAKWAPTLRTISFKGS--------PNERKAKQAKIRAG--------- 864

  Fly   846 YKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNS-YTIAYKLLLTGTPLQ 909
             :|:|:||::|.|..:.|.|..:.|..:::||.||:|:.|||....||: |...|:|:|||||||
Yeast   865 -EFDVVLTTFEYIIKERALLSKVKWVHMIIDEGHRMKNAQSKLSLTLNTHYHADYRLILTGTPLQ 928

  Fly   910 NNLEELFHLLNFLSRDKFNDLQAFQGEF------------ADVSKEEQ---VKRLHEMLGPHMLR 959
            |||.||:.||||:....||.:::|...|            .::|:||.   ::|||::|.|.:||
Yeast   929 NNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGQDKIELSEEETLLVIRRLHKVLRPFLLR 993

  Fly   960 RLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEAL-----NSKSGGGSCSLINIMMDLK 1019
            |||.||.|.:|.|.|.:|:.::||:|:..|:.:|  .|..|     |:|...|.....|.:|.||
Yeast   994 RLKKDVEKELPDKVEKVVKCKMSALQQIMYQQML--KYRRLFIGDQNNKKMVGLRGFNNQIMQLK 1056

  Fly  1020 KCCNHPYLFPSAAEEATTAAGGLYEIN-SLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLD 1083
            |.||||::|    ||.........|.| .:.:.|||..||.::|.:|||..||||||.|||:::|
Yeast  1057 KICNHPFVF----EEVEDQINPTRETNDDIWRVAGKFELLDRILPKLKATGHRVLIFFQMTQIMD 1117

  Fly  1084 ILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLATADTVIIYD 1148
            |:||||.....||.|:||......|.|.:..||||.::...|:|||||||||:||.|||||||:|
Yeast  1118 IMEDFLRYINIKYLRLDGHTKSDERSELLRLFNAPDSEYLCFILSTRAGGLGLNLQTADTVIIFD 1182

  Fly  1149 SDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGAN- 1212
            :|||||.|:||..|||||||.|:|.|.|.:|.|||||.:.:.|.:|:.:...|::   .||..|
Yeast  1183 TDWNPHQDLQAQDRAHRIGQKNEVRILRLITTNSVEEVILERAYKKLDIDGKVIQ---AGKFDNK 1244

  Fly  1213 FTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEE----KESWANEYLS-SFK 1272
            .|.:|.:.:||    .|.   |.||          |...:...|:||    |:|..||.|: :.:
Yeast  1245 STSEEQEALLR----SLL---DAEE----------ERRKKRESGVEEEEELKDSEINEILARNDE 1292

  Fly  1273 VASYATKEEEE----EEETEIIKQDAENSD-PAYWVKLLRHHYEQHQEDVGRSL----------- 1321
            ..:..|:.:|:    |||..:..:..|.|: |           :.:..|:|..|
Yeast  1293 EMAVLTRMDEDRSKKEEELGVKSRLLEKSELP-----------DIYSRDIGAELKREESESAAVY 1346

  Fly  1322 -GKGKRVRKQVNYTDG--------GVVAADTTRDD--SNWQDNGSEYNSEYSAGSDEDGGDDDFD 1375
             |:|.|.||...|.|.        ....:|..::|  :..|....|..||...|:.|..|::...
Yeast  1347 NGRGARERKTATYNDNMSEEQWLRQFEVSDDEKNDKQARKQRTKKEDKSEAIDGNGEIKGENIDA 1411

  Fly  1376 DQNG-------AERKAKRRLERRDDRPLPPLLARVGGNIEVLGFNARQRKSFLNAIMRYGMPPQD 1433
            |.:|       ||.:|...|...||                 .|.:::||:        |.|
Yeast  1412 DNDGPRINNISAEDRADTDLAMNDD-----------------DFLSKKRKA--------GRP--- 1448

  Fly  1434 AFNSQWLVRDLRGKSERNFKAYVSLFMRHLCEPGA--------DN--AETFADGVPR 1480
                       ||:.::     |.|......||.|        ||  :|.|.| :|:
Yeast  1449 -----------RGRPKK-----VKLEGSENSEPPALESSPVTGDNSPSEDFMD-IPK 1488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357	11/65 (17%)
		TNG2	<282..422	CDD:227367	34/211 (16%)
		PHD1_CHD_II	380..422	CDD:277006	7/44 (16%)
		PHD2_CHD_II	440..482	CDD:277007	10/56 (18%)
		CD1_tandem_CHD3-4_like	487..557	CDD:349314	12/77 (16%)
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	8/53 (15%)
		PLN03142	720..>1234	CDD:215601	228/536 (43%)
		DUF1087	<1292..1334	CDD:461922	11/54 (20%)
		CHDII_SANT-like	1380..1517	CDD:461920	24/111 (22%)
		CHDCT2	1757..1902	CDD:462358
SNF2	NP_014933.3	QLQ	248..281	CDD:462622	5/32 (16%)
		HSA	<617..656	CDD:462194	8/38 (21%)
		PLN03142	650..>1297	CDD:215601	269/726 (37%)
		SnAC	1303..1369	CDD:464219	16/76 (21%)
		Bromo_SNF2	1550..1652	CDD:99950