Protein Alignment Mi-2 and RAD26

DIOPT Version :10

• Sequence 1: NP_001014591.1
• Gene: Mi-2 / 40170
• FlyBaseID: FBgn0262519
• Length: 1983
• Species: Drosophila melanogaster
• Sequence 2: NP_012569.1
• Gene: RAD26 / 853492
• SGDID: S000003796
• Length: 1085
• Species: Saccharomyces cerevisiae
• Alignment Length: 796
• Identity: 224/796 - (28%)
• Similarity: 352/796 - (44%)
• Gaps: 149/796 - (18%)

  Fly   570 SLDEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGSTM---Y 631
            |||.|:..|.:....||       :|.|:..|:..:|               .|..|.:..   |
Yeast   161 SLDTANREYAKNDEQKD-------EDFEMATEQMVEN---------------LTDEDDNLSDQDY 203

  Fly   632 LVKWRELPYDKSTWEEEGDD-----IQGLR------QAID-----YYQDLRAVCTSETTQSRSKK 680
            .:..:|...|:   |||.||     ::.||      :|.|     |||:            |.||
Yeast   204 QMSGKESEDDE---EEENDDKILKELEDLRFRGQPGEAKDDGDELYYQE------------RLKK 253

  Fly   681 SKKGRKSKLKVEDDEDRPVKHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQ-LHPYQIEGINWLRY 744
            ..|.|  ....:...|.| :...|.|..|...|..:::     :.|.... |..||...:.||..
Yeast   254 WVKQR--SCGSQRSSDLP-EWRRPHPNIPDAKLNSQFK-----IPGEIYSLLFNYQKTCVQWLYE 310

  Fly   745 SWGQGIDTILADEMGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCI 809
            .:.|....|:.||||||||||.:.|:.:|:..|...||.|:..|.:.:..|..||:.|.|....:
Yeast   311 LYQQNCGGIIGDEMGLGKTIQVIAFIAALHHSGLLTGPVLIVCPATVMKQWCNEFQHWWPPLRTV 375

  Fly   810 TY--IGD---KDSRAVIRENELSFEEGAIRGSKVSRLRTTQYK---------------------- 847
            ..  :|.   .|.:..:.||:|   |..|..||.|......:|
Yeast   376 ILHSMGSGMASDQKFKMDENDL---ENLIMNSKPSDFSYEDWKNSTRTKKALESSYHLDKLIDKV 437

  Fly   848 ---FNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSKFFRILNSYTIAYKLLLTGTPLQ 909
               .::|:|:|..:.:.:..|..:.|...|:||.|::::..|:............:::|:|||:|
Yeast   438 VTDGHILITTYVGLRIHSDKLLKVKWQYAVLDEGHKIRNPDSEISLTCKKLKTHNRIILSGTPIQ 502

  Fly   910 NNLEELFHLLNFLSRDKFNDLQAFQGEF------------ADVSKEEQVK---RLHEMLGPHMLR 959
            |||.||:.|.:|:...|...|..||.:|            .::..:...|   .|.:::.|::||
Yeast   503 NNLTELWSLFDFIFPGKLGTLPVFQQQFVIPINIGGYANATNIQVQTGYKCAVALRDLISPYLLR 567

  Fly   960 RLKTDVLKNMPSKSEFIVRVELSAMQK-KFYKFILTKNYEALNSKSGGGSCSLINIMMDLKKCCN 1023
            |:|.||.|::|.|.|.::..:|:..|: |:.:|:.:.:   ||....|....|..|.: |:|.||
Yeast   568 RVKADVAKDLPQKKEMVLFCKLTKYQRSKYLEFLHSSD---LNQIQNGKRNVLFGIDI-LRKICN 628

  Fly  1024 HPYLFPSAAEEATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLIFSQMTKMLDILEDF 1088
            ||.|.....:......|.       .|.:||:.::.::|.....|.::.|:|:|..:||||||:|
Yeast   629 HPDLLDRDTKRHNPDYGD-------PKRSGKMQVVKQLLLLWHKQGYKALLFTQSRQMLDILEEF 686

  Fly  1089 LEGE-----QYKYERIDGGITGTLRQEAIDRFNAPGAQQF-VFLLSTRAGGLGINLATADTVIIY 1147
            :..:     ...|.|:||......||..:||||   .:.| ||||:||.||||:||..|:.:||:
Yeast   687 ISTKDPDLSHLNYLRMDGTTNIKGRQSLVDRFN---NESFDVFLLTTRVGGLGVNLTGANRIIIF 748

  Fly  1148 DSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVVRPGMGGKGAN 1212
            |.||||..|:||..||.||||..:|.|||.:...|:||::......|..||:.::   ...|...
Yeast   749 DPDWNPSTDMQARERAWRIGQKREVSIYRLMVGGSIEEKIYHRQIFKQFLTNRIL---TDPKQKR 810

  Fly  1213 FTK-QELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWAN----EYLSSFK 1272
            |.| .||.|:...|.|:.:..::..|.:   .|....|.:..:...::.|...|    ..|.||
Yeast   811 FFKIHELHDLFSLGGENGYSTEELNEEV---QKHTENLKNSKSEESDDFEQLVNLSGVSKLESF- 871

  Fly  1273 VASYATKEEEEEEETE 1288
               |..||::|..:||
Yeast   872 ---YNGKEKKENSKTE 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mi-2	NP_001014591.1	CHDNT	138..191	CDD:462357
		TNG2	<282..422	CDD:227367
		PHD1_CHD_II	380..422	CDD:277006
		PHD2_CHD_II	440..482	CDD:277007
		CD1_tandem_CHD3-4_like	487..557	CDD:349314
		CD2_tandem_CHD3-4_like	610..664	CDD:349309	16/72 (22%)
		PLN03142	720..>1234	CDD:215601	171/567 (30%)
		DUF1087	<1292..1334	CDD:461922
		CHDII_SANT-like	1380..1517	CDD:461920
		CHDCT2	1757..1902	CDD:462358
RAD26	NP_012569.1	HepA	<222..792	CDD:440319	178/606 (29%)
		CSB_WHD	1019..1080	CDD:439329