DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mi-2 and CHD6

DIOPT Version :9

Sequence 1:NP_001014591.1 Gene:Mi-2 / 40170 FlyBaseID:FBgn0262519 Length:1983 Species:Drosophila melanogaster
Sequence 2:XP_016883588.1 Gene:CHD6 / 84181 HGNCID:19057 Length:2716 Species:Homo sapiens


Alignment Length:2056 Identity:531/2056 - (25%)
Similarity:796/2056 - (38%) Gaps:613/2056 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 VEDVCSAFSVCNVEIEYSEEELQSLTTYKAFMHHVRPILQKENPKIAAPKLVMLVAAKWREFCES 189
            :|||.| ..:...::..:|||..:|...|...|:.                              
Human    49 IEDVAS-HCLPQKDLYTAEEEAATLFPRKMTSHNG------------------------------ 82

  Fly   190 NPHIQQEGGAAGSGGSAGQARSVTGDEP-----EEPRSSRSSRNEKPDDIYEEAVEEEEEEEEEE 249
                .::.|..|:|....:.:...||:.     .:.|..:..|..:|.:..|....:|.::.:|.
Human    83 ----MEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAKEPKKAKEH 143

  Fly   250 KKPRRKRSGRGKKGRRPSGKVPTLKIKLLGKRKRDSSDEEQDASGASERDSDLEFERMLQKSDDS 314
            |:|::|..  .||.|:|                       ::|||..|                 
Human   144 KEPKQKDG--AKKARKP-----------------------REASGTKE----------------- 166

  Fly   315 ADEKEAPVSSKADNSAPAAQDDGSGAPVVRKKAKTKIGNKFKKKNKLKKTKNFPEGEDGEHEHQD 379
            |.||.:...|.|...:..|..:....||.:||         |.|.|.:.|....|.:.|      
Human   167 AKEKRSCTDSAARTKSRKASKEQGPTPVEKKK---------KGKRKSETTVESLELDQG------ 216

  Fly   380 YCEVCQQGGEIILCDTCPRAYHLVCLEPELDEPPEGKWSC-PHCEADGGAAEEEDDDEHQEFCRV 443
                                    ...|.|..|.|...|. ......|...:....:|..:| :|
Human   217 ------------------------LTNPSLRSPEESTESTDSQKRRSGRQVKRRKYNEDLDF-KV 256

  Fly   444 CKDGGELLCCDSC--PSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWRWAQRSNDD 506
            ..|.||.:.....  .||.....|....:..|:.|           ....|||:..:..|..:..
Human   257 VDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDD-----------ANIIEKILASKTVQEVHPG 310

  Fly   507 GPSTSKGSKNSNSRVREYFIKWHNMSYWHCEWVPEVQLDVHHPLMIRSFQRKYDMEEPPKFEESL 571
            .|...         :..:::|:.|.||.||:|....:|                 |:.|:..:  
Human   311 EPPFD---------LELFYVKYRNFSYLHCKWATMEEL-----------------EKDPRIAQ-- 347

  Fly   572 DEADTRYKRIQRHKDKVGMKANDDAEVLEERFYKNGVKPEWLIVQRVINHRTARDGS-----TMY 631
                    :|:|.::|.....:...|..|:.|     .|:::.|.|::.....:|..     |.|
Human   348 --------KIKRFRNKQAQMKHIFTEPDEDLF-----NPDYVEVDRILEVAHTKDAETGEEVTHY 399

  Fly   632 LVKWRELPYDKSTWEEEGDDIQGLRQAIDYYQDLRAVCTSETTQSRSKKSKKGRKSKLKVEDDED 696
            ||||..|||::||||.|.|        :|                           ..||::.|.
Human   400 LVKWCSLPYEESTWELEED--------VD---------------------------PAKVKEFES 429

  Fly   697 RPV----KHYTPPPEKPTTDLKKKYEDQPAFLEGTGMQLHPYQIEGINWLRYSWGQGIDTILADE 757
            ..|    ||.    |:|.:|..:|.|....:....  ||..||:||:|||.::|....:.|||||
Human   430 LQVLPEIKHV----ERPASDSWQKLEKSREYKNSN--QLREYQLEGMNWLLFNWYNRKNCILADE 488

  Fly   758 MGLGKTIQTVTFLYSLYKEGHCRGPFLVAVPLSTLVNWEREFELWAPDFYCITYIGDKDSRAVIR 822
            ||||||||::|||..::..| ..||||:..||||:.||||||..|. :...|.|.|.:.||.:|:
Human   489 MGLGKTIQSITFLSEIFLRG-IHGPFLIIAPLSTITNWEREFRTWT-EMNAIVYHGSQISRQMIQ 551

  Fly   823 ENELSFEEGAIRGSKVSRLRTTQYKFNVLLTSYELISMDAACLGSIDWAVLVVDEAHRLKSNQSK 887
            :.|:.:.:.  :|:.:|.:    :||:|::|::|:|..|...|..|.|:.:::|||||||:...|
Human   552 QYEMVYRDA--QGNPLSGV----FKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCK 610

  Fly   888 FFRILNSYTIAYKLLLTGTPLQNNLEELFHLLNFLSRDKFNDLQAFQGEFADVSKEEQVKRLHEM 952
            ....|....:.:|:|||||||||::||||.|||||...:|....||..||.|:..|||||:|..:
Human   611 LLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSI 675

  Fly   953 LGPHMLRRLKTDVLKNMPSKSEFIVRVELSAMQKKFYKFILTKNYEALNSKSGGGSC-SLINIMM 1016
            |.|.||||||.||.||:..|.|.|:.|||:.:|||:|:.||.||:..|...:...:. :|||.||
Human   676 LKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMM 740

  Fly  1017 DLKKCCNHPYLFPSAAE-------EATTAAGGLYEINSLTKAAGKLVLLSKMLKQLKAQNHRVLI 1074
            :|:||||||||...|.|       :..:.....:::.::.:|||||||:.|:|.:|.|..|:|||
Human   741 ELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLI 805

  Fly  1075 FSQMTKMLDILEDFLEGEQYKYERIDGGITGTLRQEAIDRFNAPGAQQFVFLLSTRAGGLGINLA 1139
            ||||.:.||||||:|...:|.||||||.:.|.|||.|||||..|.:.:|||||.||||||||||.
Human   806 FSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLT 870

  Fly  1140 TADTVIIYDSDWNPHNDIQAFSRAHRIGQANKVMIYRFVTRNSVEERVTQVAKRKMMLTHLVV-- 1202
            .|||.||:||||||.||:||.:|.|||||:..|.:||.:||||.|..:...|..|:.|...|:  
Human   871 AADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQD 935

  Fly  1203 --RPGMGGKGA-NFTKQELDDILRFGTEDLFKEDDKEEAIHYDDKAVAELLDRTNRGIEEKESWA 1264
              |.| |..|. ..:|.|::|:||.|...... |:::|...:.::.:.::|.|....|..:....
Human   936 INRKG-GTNGVQQLSKMEVEDLLRKGAYGALM-DEEDEGSKFCEEDIDQILQRRTHTITIQSEGK 998

  Fly  1265 NEYLSSFKVASYATKEEEEEEETEIIKQDAENSDPAY---WVKLLRHHYEQHQEDVGRSLGKGKR 1326
            .   |:|..||:.....         :.|....||.:   |.|:.....|...|.....:.: .|
Human   999 G---STFAKASFVASGN---------RTDISLDDPNFWQKWAKIAELDTEAKNEKESLVIDR-PR 1050

  Fly  1327 VRKQVNYTDGGVVAADTTRDDSNWQDNGSEYNSEYSAGSDEDGGDDDFDDQNGAERKAKRRLERR 1391
            ||||            |...:|..:|...|: ||..:.|||             .....|||..:
Human  1051 VRKQ------------TKHYNSFEEDELMEF-SELDSDSDE-------------RPTRSRRLNDK 1089

  Fly  1392 DDRPLPPLLARVGGNIEVLGF----------------NARQRKSFLNAIMRYGM----------- 1429
            ..|.|.....||..|:.:.|:                |.:..:....|::.|.:           
Human  1090 ARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYKGDEKIKS 1154

  Fly  1430 -------PPQDAFNSQWL----------VRDLRGKSERNFKAYVSLFMRHLCEPGADNAETFA-- 1475
                   |.:|. .:|.|          .|..:||..:|          .|..|...:|:..|  
Human  1155 FIWELITPTKDG-QAQTLQNHSGLSAPVPRGRKGKKTKN----------QLLIPELKDADWLATC 1208

  Fly  1476 --------DGVPREGLSRQH---VLTRIGVMSLIRKKVQEFEHINGYYSMPELILKPCE------ 1523
                    ||..:.  .:||   ||.|:.::               ||...|::.:..|      
Human  1209 NPEVVLHDDGYKKH--LKQHCNKVLLRVRML---------------YYLKAEILGEAAEKAFEGS 1256

  Fly  1524 PVR---------------------------------------SALKQDVAALEAPPTGGNVDKSA 1549
            |.|                                       :|::.|.|.......|...:||.
Human  1257 PARELDVPLPDIDYMEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSL 1321

  Fly  1550 TTSNSVTPATSAAP--SPAPASEKGEDK----DKDSEKEKDKTSAEKSEVKQEQEAEEDKKPGDV 1608
            :....||..||..|  ......:..|||    .|.:|...|......||.|.:..|.:|....| 
Human  1322 SAEQGVTDGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQDGSDPD- 1385

  Fly  1609 KQENPVEEAAGDTKPSDAEVKTEVAKTE--PKEETKDPE----------VKEE--PKTEEKE--- 1656
            |...||..|.      .|.::..|...:  .::|...||          |:||  .:|.|.:   
Human  1386 KSPWPVSSAL------TARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRTSEMDLIN 1444

  Fly  1657 ---------KEKVDDKKPIPPTTVIDDDDDDVMIVKEDGELEKPSASSPKDQKAVAAATSAATGA 1712
                     :|:.|..:.:....|:.|.:      |:..:..:....|..|:|            
Human  1445 KEAQKRWTRREQADFYRTVSSFGVVYDQE------KKTFDWTQFRIISRLDKK------------ 1491

  Fly  1713 TGKGAEDSLEVLKRKFMF---NIA------DGG--FTELHTLWLNEEKAA--------------- 1751
                :::|||.....|:.   |:.      |||  .|.::...:.||:||               
Human  1492 ----SDESLEQYFYSFVAMCRNVCRLPTWKDGGPPDTTIYVEPITEERAARTLYRIELLRKVREQ 1552

  Fly  1752 --------------VPGREYEIWHR--RHDYWLLAGIVTHGYGRWQDIQNDIRFAIINEPFKMDV 1800
                          .|.....:|..  :||..||.|...||..|..       ..|:|:|     
Human  1553 VLKCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTD-------CYIMNDP----- 1605

  Fly  1801 GKGNFLEIKNKFLARRFKLLEQALVIEEQLRRAAYLNLAQD-------PSHPAMSLNARFAEVEC 1858
             :.:||:                          ||.|.||.       |.:............|.
Human  1606 -QLSFLD--------------------------AYRNYAQHKRSGTQAPGNLCCLYQTNSKLYES 1643

  Fly  1859 LAESHQHLSKESLAGNKPANAV---------------LHKVLNQLEELLSDMKSDVSRLPATLAR 1908
            |..|....:.|||. |:|.|.|               ....::::::::| :..|.|.||.:|..
Human  1644 LTYSQMSRTSESLE-NEPENLVRVESRDDHLSLPDVTCENFISKVQDVIS-INHDESLLPESLES 1706

  Fly  1909 IPPVAQRLQMSERSILSRLAATAGNASNAAQLMAQFPAGFQ 1949
            :        |..:.:||                 |.|:.||
Human  1707 M--------MYGKKVLS-----------------QEPSSFQ 1722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mi-2NP_001014591.1 CHDNT 138..190 CDD:285335 6/51 (12%)
PHD1_CHD_II 380..422 CDD:277006 5/42 (12%)
PHD2_CHD_II 440..482 CDD:277007 10/43 (23%)
CHROMO 490..558 CDD:237991 13/67 (19%)
CHROMO 615..667 CDD:214605 19/56 (34%)
SNF2_N 734..1028 CDD:278600 139/294 (47%)
DEXDc 751..907 CDD:238005 65/155 (42%)
Helicase_C 1053..1167 CDD:278689 74/113 (65%)
DUF1087 <1292..1337 CDD:283996 12/47 (26%)
DUF1086 1380..1517 CDD:283992 33/193 (17%)
CHDCT2 1756..1927 CDD:285336 39/194 (20%)
CHD6XP_016883588.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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